Search

Abstract: A tandem sensor for Pd2+ and CN− ions based on perylenediimide‐peptide conjugate is reported. The probe showed high selectivity toward Pd2+ ion over other metal cations and the sensitivity was observed to be 0.55 ppb, significantly lower than other similar chemosensors. Binding with Pd2+ leads to aggregation of the ligand and consequently results in quenching of its emission. The quenched emission can be turned on in presence of CN− ions as the cyanides form stronger complex with Pd2+ leading to disaggregation of the aggregated system. The system was found to be extremely selective to CN− and the detection limit in this case was calculated to be as low as 0.226 ppb. The sensor is also utilized to construct a practical and simple TLC based tool to sense these two ions efficiently. [ABSTRACT FROM AUTHOR]

Abstract: To develop a new sensor for histone, a series of Naphthalenediimide (NDI) derivatieves were subjected to DNA binding studies and the NDI derivative with strongest affinity for DNA was selected. This NDI‐DNA hybrid is used for highly selective and sensitive detection of a DNA binding protein, histone which dislodges the intercalated NDI groups and thus “turn‐on” the emission. [ABSTRACT FROM AUTHOR]

A single amino acid in a peptide sequence can play an important role to tune the self‐assembly and hydrogelation behaviour. Here, a C‐terminal cysteine‐containing ultrashort peptide hydrogelator forms hydrogel through non‐covalent and covalent interactions. Interestingly, the hydrogel is insoluble in water and buffer solutions at different pH values (1‐13) and is thixotropic and injectable. In recent years, removing dyes from contaminated water has become a significant concern because of the shortage of freshwater resources. Therefore, the adsorption of dyes through a reliable, straightforward, nontoxic, cheap, and environmentally friendly adsorbent has become a popular topic. Hence, the hydrogelator was exploited to remove organic dyes from wastewater, harnessing its applicability in the gel phase and solid supports (filter paper and cotton). [ABSTRACT FROM AUTHOR]

Cover Feature: Disulphide Cross-Linked Ultrashort Peptide Hydrogelator for Water Remediation (Chem. Eur. J. 37/2023) Keywords: disulphide; dye removal; hydrogels; peptides; self-assembly EN disulphide dye removal hydrogels peptides self-assembly 1 1 1 07/05/23 20230703 NES 230703 B Unleashing the power of peptide hydrogels for environmental remediation b : This is a tale of an ultrashort peptide hydrogel (azo-KC) and its efficiency for wastewater treatment. Disulphide, dye removal, hydrogels, peptides, self-assembly. [Extracted from the article]

In living systems, dissipative processes are driven by the endergonic hydrolysis of chemical fuels such as nucleoside triphosphates. Now, through a simple model system, a transient self‐assembled state is realized by utilizing the catalytic effect of histidine on the formation and breaking of ester bonds. First, histidine facilitates the ester bond formation, which then rapidly co‐assembles to form a self‐supporting gel. An out‐of‐equilibrium state is realized owing to the cooperative catalysis by the proximal histidines in the assembled state, driving the second pathway and resulting in disassembly to sol. Cooperative effects that use the dual role of imidazoles as nucleophile and as proton donor is utilized to achieve transient assemblies. This simple system mimics the structural journey seen in microtubule formation where the substrate GTP facilitates the non‐covalent assembly and triggers a cooperative catalytic process, leading to substrate hydrolysis and subsequent disassembly. [ABSTRACT FROM AUTHOR]

In living systems, dissipative processes are driven by the endergonic hydrolysis of chemical fuels such as nucleoside triphosphates. Now, through a simple model system, a transient self‐assembled state is realized by utilizing the catalytic effect of histidine on the formation and breaking of ester bonds. First, histidine facilitates the ester bond formation, which then rapidly co‐assembles to form a self‐supporting gel. An out‐of‐equilibrium state is realized owing to the cooperative catalysis by the proximal histidines in the assembled state, driving the second pathway and resulting in disassembly to sol. Cooperative effects that use the dual role of imidazoles as nucleophile and as proton donor is utilized to achieve transient assemblies. This simple system mimics the structural journey seen in microtubule formation where the substrate GTP facilitates the non‐covalent assembly and triggers a cooperative catalytic process, leading to substrate hydrolysis and subsequent disassembly. Self‐driving: A simple fuel‐driven self‐assembled system is demonstrated that achieves an out‐of‐equilibrium state by dissipating energy from the assembled structures. This occurs by utilizing cooperative effects of the proximally located histidines, which catalyze the hydrolysis of ester bonds of the lipid‐tailed amphiphile. [ABSTRACT FROM AUTHOR]