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Thymic tumors are very rare neoplasms in children and account for less than 1% of mediastinal tumors in pediatric patients. One‐third of the pediatric patients present with symptoms related to the compression of the tumor mass on the surrounding anatomic structures, and paraneoplastic syndromes such as myasthenia gravis, pure red cell aplasia, acquired hypogammaglobulinemia, and connective tissue disorders, which rarely occur in children with thymic tumors. Herein, we report a case of thymic carcinoma mimicking the symptoms of a connective tissue disease with symmetrical polyarthritis accompanying myositis, fever, weight loss, and malaise in a 15‐year‐old male patient. To our knowledge, this is the first case pediatric thymic carcinoma accompany with severe polyarthritis and myopathy, thus we have reviewed the current literature regarding the cases of thymic malignancies coexisting with paraneoplastic syndromes in children. [ABSTRACT FROM AUTHOR]

In this study, we aimed to investigate the effects of chronic sleep deprivation on mucociliary clearance, which is the primary defence mechanism of the upper airway tract and nasal mucosal histology. Forty‐two Wistar Albino rats (250‐300 g), 8 or 12 weeks old, were randomly assigned into three groups as follows. The first sleep‐deprivation group consisted of 14 rats (A), another 14 of them were assigned to platform group (B), and the remaining 14 were included to the home cage control group (C). For the two deprivation groups (A and B), the modified multiple platform method (MMPM) was used to induce sleep deprivation for 21 days. Tc‐99m MAA rhinoscintigraphy was performed to assess mucociliary clearance and the nasal histopathological changes of the sacrificed rats were also examined. Mucociliary clearance was significantly higher in sleep deprivation (A) and deprivation control (B) groups than the control group (C) (p =.037). The ratio of columnar ciliary was significantly higher in group A and B than in the control group (p =.003). The transitional epithelial ratio in groups A and B was also significantly increased compared with group C (p =.04). The control group's squamous epithelial ratio was increased compared to the sleep‐deprived groups (p =.003). There was a significantly increased inflammatory response in the ciliated columnar epithelium in groups A and B compared to group C (p =.02). For the first time in the literature, we demonstrated that chronic sleep deprivation has caused a significant increase in mucociliary clearance speed and in the number of ciliary cells. [ABSTRACT FROM AUTHOR]