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Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well-known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%-3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence-based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in-depth investigations in the topic., (© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

Meta‐aramid paper is widely used in transformers because of its perfect heat resistance and dielectric properties. However, the loose structure and the voids of meta‐aramid paper may lead to lower breakdown strength, which will limit the applications of the insulated paper in harsh environment. Accordingly, it is urgent to enhance the dielectric breakdown strength of meta‐aramid paper. This work reports a simple and effective way to increase the breakdown strength of meta‐aramid paper. The paper was coated with salt‐free poly(m‐phenylene isophalamide) (PMIA) slurry and the solid contents of PMIA slurry were 4%, 6%, 8%, and 10%, respectively. To obtain salt‐free PMIA slurry, the meta‐aramid spun fibers were dissolved in dimethylacetamide. After coating 10% PMIA slurry on meta‐aramid paper, the paper demonstrated the best comprehensive performance. The tensile strengths in the cross and machine direction reached 40.67 and 90.76 MPa, which were increased by 29.93% and 20.16% compared with pristine paper. Meanwhile, the dielectric breakdown strength was up to 42.75 kV/mm (the breakdown strength of pristine paper was only 16.41 kV/mm). Because no crosslinking agent and adhesive were used, the coated meta‐aramid paper still maintained excellent properties. [ABSTRACT FROM AUTHOR]

The erratic, intermittent, and unpredictable nature of sweat production, resulting from physiological or psychological fluctuations, poses intricacies to consistently and accurately sample and evaluate sweat biomarkers. Skin‐interfaced microfluidic devices that rely on colorimetric mechanisms for semi‐quantitative detection are particularly susceptible to these inaccuracies due to variations in sweat secretion rate or instantaneous volume. This work introduces a skin‐interfaced colorimetric bifluidic sweat device with two synchronous channels to quantify sweat rate and biomarkers in real‐time, even during uncertain sweat activities. In the proposed bifluidic‐distance metric approach, with one channel to measure sweat rate and quantify collected sweat volume, the other channel can provide an accurate analysis of the biomarkers based on the collected sweat volume. The closed channel design also reduces evaporation and resists contamination from the external environment. The feasibility of the device is highlighted in a proof‐of‐the‐concept demonstration to analyze sweat chloride for evaluating hydration status and sweat glucose for assessing glucose levels. The low‐cost yet highly accurate device provides opportunities for clinical sweat analysis and disease screening in remote and low‐resource settings. The developed device platform can be facilely adapted for the other biomarkers when corresponding colorimetric reagents are exploited. [ABSTRACT FROM AUTHOR]

Three‐dimensional paper‐based microfluidic devices have shown great potential in various applications, including point‐of‐care diagnostics, environmental monitoring, and tissue engineering. However, their fabrication is still limited to stacking and origami methods. Inspired by the art of bamboo braiding in China, we developed a novel fabrication technique based on the braiding concept to create three‐dimensional paper‐based microfluidic devices with PDMS‐impregnated paper substrate as the building units. The resulting three‐dimensional paper device brings unique advantages, including compactness, facile disassembly, and real‐time flow visualization. The multiplexed glucose analysis with a braided device integrated with 16‐switchable valves for flow control was further fabricated to demonstrate the device's applicability. We envision braiding‐based fabrication technology opening new possibilities and bringing broad applications for three‐dimensional paper microfluidic devices. [ABSTRACT FROM AUTHOR]

Addressing solid waste recycling, this study aims to develop biodegradable kraft paper from buffing dust (BD) and post‐consumed jute fiber (JF). Employing a simple solution casting method with a polyurethane binder, the kraft paper was fabricated and characterized using UV–Vis spectroscopy, FTIR, XRD, SEM, TGA, OTR, biodegradability, and tensile tests. The findings revealed covalent and hydrogen bonding between BD and JF, forming a uniform surface. Notably, the composite exhibited improved thermal stability, enhanced gas barrier properties, and biodegradability compared to individual components. Furthermore, the composite also showed 57% higher tensile strength, 38% greater elongation, 20% increased hardness, and 9% higher density compared to buffing dust. Compared to jute fiber, the increases were 125%, 91%, 30%, and 19% respectively. Moreover, the composite excelled in gas barrier performance, surpassing BD and JF by a remarkable 61% and 73% increase respectively. These significant findings underscore the vast potential of the composite kraft paper as a versatile material suitable for various applications, including packaging, interior furnishing industries, and reinforcing elements in the footwear industry. By addressing waste management and promoting sustainability, this research contributes to the development of eco‐friendly materials that align with contemporary environmental concerns. Highlights: Covalent and hydrogen bonding enhance uniformity.Biodegradable kraft paper with improved properties.Impressive tensile strength, elongation, and hardness.Versatile material for eco‐friendly applications.Promotes sustainability and waste management. [ABSTRACT FROM AUTHOR]

Photoreversible color‐switching materials, which can reversibly change color in response to external light stimuli, have attracted increasing attention for their applications in time‐sensitive information storage and optical data storage fields. But most of the related materials are dyes or redox compounds with ultraviolet as the light source, dramatically limiting the cycling stability during discoloration processes. To address this problem, a near‐infrared (NIR)‐responsive rewritable paper via doping layered Co‐metal–organic frameworks (MOFs) into the stable polyvinylidene fluoride matrix is reported for the first time. Layered Co‐MOF shows a rapid color‐switching characteristic between orange and black blue upon NIR illumination on/off because of the interlayer spacing changes. Benefiting from the soft network structures of the matrix, Co‐MOF can be homogeneously distributed to deliver an outstanding reversibility performance, including rapid response, coloration in a short period, and decoloration within about 3 min in ambient air. The fabrication of new photoreversible color switching system holds great potential in communication security, which offers a viable pathway to achieve ink‐free photoreversible printing. [ABSTRACT FROM AUTHOR]

Dual screen e‐Paper is expected to be useful when creating documents using reference documents. This study evaluated performances of referencing conditions using paper, e‐Paper, and LCD and suggested that the working conditions using dual screen e‐Paper brought almost the same performance as the working conditions using paper as a reference. [ABSTRACT FROM AUTHOR]

Psychodermatology is a subspecialty of dermatology that is of increasing interest to dermatologists and patients. The case for the provision of at least regional psychodermatology services across Europe is robust. Psychodermatology services have been shown to have better, quicker and more cost-efficient clinical outcomes for patients with psychodermatological conditions. Despite this, psychodermatology services are not uniformly available across Europe. In fact many countries have yet to establish dedicated psychodermatology services. In other countries psychodermatology services are in development. Even in countries where psychodermatolgy units have been established, the services are not available across the whole country. This is especially true for the provision of paediatric psychodermatology services. Also whilst most states across Europe are keen to develop psychodermatology services, the rate at which this development is being implemented is very slow. Our paper maps the current provision of psychodermatology services across Europe and indicates that there is still very much more work to be done in order to develop the comprehensive psychodermatology services across Europe, which are so crucial for our patients., (© 2023 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.)