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Efficacious, effective and efficient communication between healthcare professionals (HCP) and patients is essential to achieve a successful therapeutic alliance. Telemedicine (TM) has been used for decades but during the COVID-19 pandemic its use has become widespread. This position paper aims to describe the terminology and most important forms of TM among HCP and patients and review the existing studies on the uses of TM for asthma and allergy. Besides, the advantages and risks of TM are discussed, concluding that TM application reduces costs and time for both, HCP and patients, but cannot completely replace face-to-face visits for physical examinations and certain tests that are critical in asthma and allergy. From an ethical point of view, it is important to identify those involved in the TM process, ensure confidentiality and use communication channels that fully guarantee the security of the information. Unmet needs and directions for the future regarding implementation, data protection, privacy regulations, methodology and efficacy are described., (© 2023 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

In drug hypersensitivity, drug provocation testing (DPT), also called drug challenge, is the gold standard for investigation. In recent years, risk stratification has become an important tool for adjusting the diagnostic strategy to the perceived risk, whilst still maintaining a high level of safety for the patient. Skin tests are recommended before DPT but may be omitted in low-risk patients. The task force suggests a strict definition of such low-risk patients in children and adults. Based on experience and evidence from studies of allergy to beta-lactam antibiotics, an algorithm on how to adjust DPT to the risk, and when to omit skin tests before DPT, is presented. For other antibiotics, non-steroidal anti-inflammatory drugs and other drugs, skin tests are poorly validated and DPT is frequently necessary. We recommend performing DPT with chemotherapeutics and biologicals to avoid unnecessary desensitization procedures and DPT with skin tests negative contrast media. We suggest DPT with anesthetics only in highly specialized centers. Specifics of DPT to proton pump inhibitors, anticonvulsants and corticosteroids are discussed. This position paper provides general recommendations and guidance on optimizing use of DPT, whilst balancing benefits with patient safety and optimizing the use of the limited available resources., (© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe and reliable tests. Evidence has emerged that the basophil activation test (BAT), an in vitro assay that mirrors the in vivo response, can be a complementary test for many drugs. In this position paper, members of Task Force (TF) "Basophil activation test in the evaluation of Drug Hypersensitivity Reactions" from the European Academy of Allergy and Clinical Immunology (EAACI) present the data from a survey about the use and utility of BAT in IDHRs in Europe. The survey results indicate that there is a great interest for using BAT especially for diagnosing IDHRs. However, there are still main needs, mainly in the standardization of the protocols. Subsequently consensus-based recommendations were formulated for: (i) Technical aspects of BAT in IDHRs including type of sample, management of drugs, flow cytometry protocols, interpretation of the results; and (ii) Drug-specific aspects that should be taken into account when performing BAT in relation to betalactams, neuromuscular blocking agents, fluoroquinolones, chlorhexidine, opioids, radio contrast media, chemotherapeutics, biological agents, nonsteroidal anti-inflammatory drugs, COVID vaccine, and excipients. Moreover, aspects in the evaluation of pediatric population have also been considered. All this indicates that BAT offers the clinician and laboratory a complementary tool for a safe diagnostic for IDHRs, although its place in the diagnostic algorithm depends on the drug class and patient population (phenotype, geography, and age). The standardization of BAT is important for generalizing this method beyond the individual laboratory., (© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

Paper was one of the greatest inventions in ancient China, and it greatly promoted the rapid development of human civilization. Even in today's electronic information age, paper and paper‐derived products are still indispensable to people's daily work and life. However, the traditional paper based on cellulose fibers from plants has some problems. For instance: (1) papermaking consumes a large amount of precious natural resources such as trees; (2) the papermaking industry causes environmental pollution; (3) the traditional paper consisting of organic cellulose fibers is highly flammable and easy to burn; (4) the traditional paper based on cellulose fibers turns to yellow color with time; (5) the lifetime of the traditional paper is relatively short because of the degradation of cellulose fibers. More efforts are needed to investigate and solve these problems facing the traditional paper. In recent years, a new kind of multifunctional fire‐resistant paper based on ultralong hydroxyapatite nanowires has been developed and investigated for various applications, and many research findings have been documented in the literature. This review article provides a comprehensive summary and discussion on recent research advances for this new kind of multifunctional fire‐resistant paper based on ultralong hydroxyapatite nanowires, including the synthesis, properties, applications, and future perspectives. [ABSTRACT FROM AUTHOR]

It is crucial and significant to boost the utilization of renewable resources and exploitation of biodegradable materials alternative to petrochemical plastics. Waste paper, mainly composed of cellulose (82–95 wt%) and derived from the lignocellulose, is a type of abundant, renewable, and biodegradable resource, whose recycling use and conversion to high value‐added products can reduce the pressure on the environment and exert immense economic benefits. Herein, four kinds of common waste paper (e.g., printing paper, newspaper, straw paper and roll paper) were converted into cellulose‐based bioplastic membranes by using ionic liquid 1‐butyl‐3‐methyl‐imidazolium chloride as solvent. The cellulose‐based membranes are smooth and compact, and their mechanical strength is prominently improved about 3–100 times comparison with the original paper. The maximum tensile strength of the film (F4) is over 127 Mpa and its optical transmittance reaches 80% at 450–800 nm wavelength. Besides, this kind of cellulose‐based films have excellent biodegradability. Thus, the results demonstrated that the cellulose‐based bioplastic membranes stemmed from waste paper possess a magnificent application prospect. [ABSTRACT FROM AUTHOR]

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BACKGROUND: This work proposes the use of a simple, inexpensive method for the hydrothermal synthesis of fluorescent carbon dot nanoparticles (CDs) from rice starch aimed at the determination of Hg2+ in water. The proposed method involved using a paper‐based analytical device coupled to a 3D plate, with a UV‐LED chamber and a smartphone for the acquisition and analysis of the fluorescence digital images of the CDs. RESULTS: The size of the carbon dots ranged from 0.5 to 3 nm, with an average particle size of ~1 nm. The functionalization of carbon dots with methimazole allowed a high selective for Hg2+ determination. The results obtained showed a linear response R2 of 0.997 and Hg2+ concentration in the range of 0.5–45.0 μmol L−1 with a limit of detection and limit of quantitation of 0.23 and 0.62 μmol L−1, respectively. The results of the study show that there were no significant differences, at 95% confidence level, between the data obtained from the application of the proposed method and the reference method. CONCLUSION: The proposed method is in line with the principles of green chemistry, as it involves the use of renewable sources for starch extraction and a hydrothermal synthesis process that does not employ toxic reagents. In addition, the method employs only 15 μL reagent/sample. © 2024 Society of Chemical Industry (SCI). [ABSTRACT FROM AUTHOR]

Highlights This study investigated converting abundant paper mill waste, de‐inked paper sludge (DPS), into value‐added medium‐density fiberboard (MDF) panels. The objective was to repurpose this solid waste into a valuable material that aligns with the principles of a circular economy. Previous research has examined the addition of paper sludge to wood composites, but there is limited information on the specific incorporation of DPS into MDF production. This investigation offers new insights into this application. MDF panels were manufactured using hardwood fibers, with varying levels of urea‐formaldehyde resin (10% and 12% by weight) and different loadings of DPS (ranging from 0% to 50% by weight). X‐ray diffraction analysis revealed the presence of defective DPS fiber crystals. Contact angle measurements confirmed that DPS had poor wettability, corresponding to increased water absorption. As more DPS was incorporated, the mechanical properties of the panels progressively weakened due to defective fibers and poor adhesion between the fibers and the matrix. This was evident in scanning electron microscopy micrographs, which showed an escalation in interfacial flaws. Increasing the resin dosage noticeably improved the internal bond strength and reduced moisture uptake across all levels of DPS. However, at a DPS loading of 50%, the properties of the panels deteriorated by 36%–57% compared to the control MDF. Additionally, thickness swelling and water absorption increased significantly with higher DPS content, primarily due to the hydrophilic nature of the fibers. Based on optimization, it was determined that a DPS loading of 20% with a resin content of 12% provided the best balance between performance, waste utilization, cost, and moisture resistance. The reuse of abundant paper sludge supports the goals of a circular economy. However, strategies are required to tailor the processing methods and enable higher levels of recycled material without excessively compromising the key attributes of the product. Further research should focus on enhancing the quality of DPS and its compatibility with wood fibers and resin to enhance the performance of the composite material. DPS from recycled paper mill assessed for MDF production with wood fibers and resin Increasing DPS loading caused reductions in strength and adhesion of panels Water absorption and thickness swelling markedly rose with more DPS addition It was attributed to hydrophilic fibers and disrupted fiber‐matrix bonding Optimal formulation was 20% DPS loading and 12% resin content, balancing performance, waste utilization, and cost. [ABSTRACT FROM AUTHOR]

Raman microscopic measurements were used to analyse the detailed chemical composition and structure of three old papers dating from the 15th and 19th centuries. Raman mapping measurements were performed on the surface and along the cross‐section of the papers with a lateral resolution of 1 μm. The resulting Raman images visualise the detailed chemical structure of the papers including all components such as the different types of cellulose fibre, filler pigments, sizing agents, colour pigments and also inadvertently added trace particles, such as minerals or products of biological activity. The results of the paper analysis are discussed in connection with their use for the detailed characterisation and dating of paper. This study demonstrates the great potential and the possibilities offered by Raman microscopy or Raman imaging for chemical paper analysis. Raman microscopy allows new insights into the chemical composition and structure of old papers and could considerably enhance the understanding of former papermaking practices and also combat forgery and the fraud of documents and artworks on paper. [ABSTRACT FROM AUTHOR]