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Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well-known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%-3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence-based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in-depth investigations in the topic., (© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

Meta‐aramid paper is widely used in transformers because of its perfect heat resistance and dielectric properties. However, the loose structure and the voids of meta‐aramid paper may lead to lower breakdown strength, which will limit the applications of the insulated paper in harsh environment. Accordingly, it is urgent to enhance the dielectric breakdown strength of meta‐aramid paper. This work reports a simple and effective way to increase the breakdown strength of meta‐aramid paper. The paper was coated with salt‐free poly(m‐phenylene isophalamide) (PMIA) slurry and the solid contents of PMIA slurry were 4%, 6%, 8%, and 10%, respectively. To obtain salt‐free PMIA slurry, the meta‐aramid spun fibers were dissolved in dimethylacetamide. After coating 10% PMIA slurry on meta‐aramid paper, the paper demonstrated the best comprehensive performance. The tensile strengths in the cross and machine direction reached 40.67 and 90.76 MPa, which were increased by 29.93% and 20.16% compared with pristine paper. Meanwhile, the dielectric breakdown strength was up to 42.75 kV/mm (the breakdown strength of pristine paper was only 16.41 kV/mm). Because no crosslinking agent and adhesive were used, the coated meta‐aramid paper still maintained excellent properties. [ABSTRACT FROM AUTHOR]

The erratic, intermittent, and unpredictable nature of sweat production, resulting from physiological or psychological fluctuations, poses intricacies to consistently and accurately sample and evaluate sweat biomarkers. Skin‐interfaced microfluidic devices that rely on colorimetric mechanisms for semi‐quantitative detection are particularly susceptible to these inaccuracies due to variations in sweat secretion rate or instantaneous volume. This work introduces a skin‐interfaced colorimetric bifluidic sweat device with two synchronous channels to quantify sweat rate and biomarkers in real‐time, even during uncertain sweat activities. In the proposed bifluidic‐distance metric approach, with one channel to measure sweat rate and quantify collected sweat volume, the other channel can provide an accurate analysis of the biomarkers based on the collected sweat volume. The closed channel design also reduces evaporation and resists contamination from the external environment. The feasibility of the device is highlighted in a proof‐of‐the‐concept demonstration to analyze sweat chloride for evaluating hydration status and sweat glucose for assessing glucose levels. The low‐cost yet highly accurate device provides opportunities for clinical sweat analysis and disease screening in remote and low‐resource settings. The developed device platform can be facilely adapted for the other biomarkers when corresponding colorimetric reagents are exploited. [ABSTRACT FROM AUTHOR]

Three‐dimensional paper‐based microfluidic devices have shown great potential in various applications, including point‐of‐care diagnostics, environmental monitoring, and tissue engineering. However, their fabrication is still limited to stacking and origami methods. Inspired by the art of bamboo braiding in China, we developed a novel fabrication technique based on the braiding concept to create three‐dimensional paper‐based microfluidic devices with PDMS‐impregnated paper substrate as the building units. The resulting three‐dimensional paper device brings unique advantages, including compactness, facile disassembly, and real‐time flow visualization. The multiplexed glucose analysis with a braided device integrated with 16‐switchable valves for flow control was further fabricated to demonstrate the device's applicability. We envision braiding‐based fabrication technology opening new possibilities and bringing broad applications for three‐dimensional paper microfluidic devices. [ABSTRACT FROM AUTHOR]

Addressing solid waste recycling, this study aims to develop biodegradable kraft paper from buffing dust (BD) and post‐consumed jute fiber (JF). Employing a simple solution casting method with a polyurethane binder, the kraft paper was fabricated and characterized using UV–Vis spectroscopy, FTIR, XRD, SEM, TGA, OTR, biodegradability, and tensile tests. The findings revealed covalent and hydrogen bonding between BD and JF, forming a uniform surface. Notably, the composite exhibited improved thermal stability, enhanced gas barrier properties, and biodegradability compared to individual components. Furthermore, the composite also showed 57% higher tensile strength, 38% greater elongation, 20% increased hardness, and 9% higher density compared to buffing dust. Compared to jute fiber, the increases were 125%, 91%, 30%, and 19% respectively. Moreover, the composite excelled in gas barrier performance, surpassing BD and JF by a remarkable 61% and 73% increase respectively. These significant findings underscore the vast potential of the composite kraft paper as a versatile material suitable for various applications, including packaging, interior furnishing industries, and reinforcing elements in the footwear industry. By addressing waste management and promoting sustainability, this research contributes to the development of eco‐friendly materials that align with contemporary environmental concerns. Highlights: Covalent and hydrogen bonding enhance uniformity.Biodegradable kraft paper with improved properties.Impressive tensile strength, elongation, and hardness.Versatile material for eco‐friendly applications.Promotes sustainability and waste management. [ABSTRACT FROM AUTHOR]

Photoreversible color‐switching materials, which can reversibly change color in response to external light stimuli, have attracted increasing attention for their applications in time‐sensitive information storage and optical data storage fields. But most of the related materials are dyes or redox compounds with ultraviolet as the light source, dramatically limiting the cycling stability during discoloration processes. To address this problem, a near‐infrared (NIR)‐responsive rewritable paper via doping layered Co‐metal–organic frameworks (MOFs) into the stable polyvinylidene fluoride matrix is reported for the first time. Layered Co‐MOF shows a rapid color‐switching characteristic between orange and black blue upon NIR illumination on/off because of the interlayer spacing changes. Benefiting from the soft network structures of the matrix, Co‐MOF can be homogeneously distributed to deliver an outstanding reversibility performance, including rapid response, coloration in a short period, and decoloration within about 3 min in ambient air. The fabrication of new photoreversible color switching system holds great potential in communication security, which offers a viable pathway to achieve ink‐free photoreversible printing. [ABSTRACT FROM AUTHOR]

Dual screen e‐Paper is expected to be useful when creating documents using reference documents. This study evaluated performances of referencing conditions using paper, e‐Paper, and LCD and suggested that the working conditions using dual screen e‐Paper brought almost the same performance as the working conditions using paper as a reference. [ABSTRACT FROM AUTHOR]

Psychodermatology is a subspecialty of dermatology that is of increasing interest to dermatologists and patients. The case for the provision of at least regional psychodermatology services across Europe is robust. Psychodermatology services have been shown to have better, quicker and more cost-efficient clinical outcomes for patients with psychodermatological conditions. Despite this, psychodermatology services are not uniformly available across Europe. In fact many countries have yet to establish dedicated psychodermatology services. In other countries psychodermatology services are in development. Even in countries where psychodermatolgy units have been established, the services are not available across the whole country. This is especially true for the provision of paediatric psychodermatology services. Also whilst most states across Europe are keen to develop psychodermatology services, the rate at which this development is being implemented is very slow. Our paper maps the current provision of psychodermatology services across Europe and indicates that there is still very much more work to be done in order to develop the comprehensive psychodermatology services across Europe, which are so crucial for our patients., (© 2023 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.)

Paper‐based cultural relics are of great value and have been facing irreversible damage caused by multiple factors, among which acid hydrolysis and ultraviolet photodegradation are the main processes leading to paper deterioration. Paper protection highly relies on a limited range of materials with single functions, and the design of new materials that ensure long‐term safety and efficiency by simultaneously addressing the issues of acidification and UV degradation in paper is highly desired. In this study, the introduction of carbon dots (CDs)‐enhanced layered double hydroxides (LDH) 0D/2D nanohybrids (CDs/Mg‐Al LDH)  is proposed as novel dual‐functional materials for paper protection against UV degradation and acidification. Through a CDs‐assisted in situ growth strategy, CDs/Mg‐Al LDH with ultrathin thickness (≈9.1 nm) and CDs‐intercalated structure are achieved. The CDs/Mg‐Al LDH nanohybrids demonstrate high dispersibility, strong UV absorption, and remarkable photostability, resulting in protected‐paper with decelerated acidification, oxidation, and yellowing degradation processes under both accelerated UV‐aging and dry‐heat conditions. Additionally, the protected‐paper can emit uniform blue light under 365 nm UV excitation allows for easy identification of the distributed CDs/Mg‐Al LDH within the paper, marking a unique and practical feature. This research paces a new direction for the protection of paper‐based relics with emerging carbon dots‐based 0D/2D nanomaterials. [ABSTRACT FROM AUTHOR]

Personalized healthcare management is an emerging field that requires the development of environment‐friendly, integrated, and electrochemical multimodal devices. In this study, the concept of integrated paper‐based biosensors (IFP−Multi) for personalized healthcare management is introduced. By leveraging ink printing technology and a ChatGPT–bioelectronic interface, these biosensors offer ultrahigh areal‐specific capacitance (74633 mF cm−2), excellent mechanical properties, and multifunctional sensing and humidity power generation capabilities. More importantly, the IFP−Multi devices have the potential to simulate deaf‐mute vocalization and can be integrated into wearable sensors to detect muscle contractions and bending motions. Moreover, they also enable monitoring of physiological signals from various body parts, such as the throat, nape, elbow, wrist, and knee, and successfully record sharp and repeatable signals generated by muscle contractions. In addition, the IFP−Multi devices demonstrate self‐powered handwriting sensing and moisture power generation for sweat‐sensing applications. As a proof‐of‐concept, a GPT 3.5 model‐based fine‐tuning and prediction pipeline that utilizes recorded physiological signals through IFP−Multi is showcased, enabling artificial intelligence with multimodal sensing capabilities for personalized healthcare management. This work presents a promising and ecofriendly approach to developing paper‐based electrochemical multimodal devices, paving the way for a new era of healthcare advancements. [ABSTRACT FROM AUTHOR]

Owing to their high porosity and tunability, porous solids such as metal–organic frameworks (MOFs), zeolites, or activated carbons (ACs) are of great interest in the fields of air purification, gas separation, and catalysis, among others. Nonetheless, these materials are usually synthetized as powders and need to be shaped in a more practical way that does not modify their intrinsic property (i.e., porosity). Elaborating porous, freestanding and flexible sheets is a relevant shaping strategy. However, when high loadings (>70 wt.%) are achieved the mechanical properties are challenged. A new straightforward and green method involving the combination softwood bleached kraft pulp fibers (S) and nano‐fibrillated cellulose (NFC) is reported, where S provides flexibility while NFC acts as a micro‐structuring and mechanical reinforcement agent to form high loadings porous solids paper sheets (>70 wt.%). The composite has unobstructed porosity and good mechanical strength. The sheets prepared with various fillers (MOFs, ACs, and zeolites) can be rolled, handled, and adapted to different uses, such as air purification. As an example of potential application, a MOF paper composite has been considered for the capture of polar volatile organic compounds exhibiting better performance than beads and granules. [ABSTRACT FROM AUTHOR]

The de‐acidification method has always been a hotspot in the research of paper‐based cultural relics conservation science. The existing de‐acidification methods are either not thorough enough or not easy to operate, requiring innovation and breakthrough. Moreover, the strength of the paper cannot be significantly improved by the simple de‐acidification treatment. To achieve the reinforcement of paper, another intervention process is often required, and each intervention may cause damage to the fragile paper cultural relics. This study introduces electrosorption deionization technology to the conservation treatment of paper cultural relics. Based on the electrosorption technology, an integrated treatment of paper de‐acidification and reinforcement was applied to sample papers using a composite electrolyte of de‐acidification and reinforcement materials and a self‐made electrosorption device. The experimental results show that both the de‐acidification and reinforcement effects on the paper samples obtained a significant promotion. [ABSTRACT FROM AUTHOR]

Background: Taking notes during learning has benefits both during class (through writing things down to encode information) and after class (by using written notes as external storage for revision). Comparisons of note-taking methods (i.e., using paper or a computer) have mainly shown that paper leads to better learning. However, previous studies have mostly been conducted in laboratory contexts., Aims: The current study investigates university students' perceptions of the efficacity of their own preferred note-taking method, along with the strategies they employ., Sample: Data were collected from 108 university students., Methods: Students answered a questionnaire about their note-taking strategies during initial note-taking (in class) and revision (after class)., Results: The results show that students who take notes on paper do not consider their method to be more effective, but they report engaging in more reformulation and less multitasking. Students who take notes on a computer are more likely to reformat their notes, and thus to reformulate at a later stage. For all students, review sheets are mostly done on paper., Conclusions: These results suggest that although students are not necessarily aware of the benefits of reformulation associated with handwriting on paper during initial note-taking, when revising, they tend to choose handwriting and benefit from reformulation when aiming for deeper processing. Therefore, revision activities remain mainly paper-based., (© 2024 British Psychological Society.)

Lithium is perceived as an ideal anode for next generation batteries with high‐energy density. However, the critical issue of the intractable growth of Li dendrites, which leads to a poor cycling life, still remains. Herein, a hierarchical surface is designed and constructed on carbon fiber (CF) using binders in fabricated CF paper (CFP). The lightweight CF with high mechanical properties is facilitated to establish a 3D network structure as an alternative to Cu foil. The binders are transformed into oxygen‐containing amorphous carbon and sodium carbonate (Na2CO3) using a low‐temperature carbonization process, leading to uniform Li nucleation and a stable solid electrolyte interphase layer with inorganic components. In the electrochemical test, the CFP with amorphous carbon and Na2CO3 (ANCFP) shows a low Li nucleation overpotential and smooth dendrite‐free Li plating. Furthermore, the ANCFP electrode exhibits good cycling stability in half and symmetrical cells. A full‐cell assembled using a LiFePO4 cathode with high loading (≈13 mg cm−2) achieves a high‐energy density of 428 Wh kg−1 (at 0.1 C) and an excellent capacity retention of 85% at 1 C after 300 cycles. This strategy is expected to help realize highly stable Li metal anodes for practical application by suppressing Li dendrite growth. [ABSTRACT FROM AUTHOR]

Digital replication of an existing cast gold onlay anatomy to a more esthetic material for a new complete denture is challenging. A technique is presented that uses digital technology to fabricate a new maxillary complete denture with monolithic zirconia onlays that duplicate the anatomy of an existing complete denture with cast gold onlays., (© 2023 The Authors. Journal of Prosthodontics published by Wiley Periodicals LLC on behalf of American College of Prosthodontists.)

Zanubrutinib has been approved for treating patients with different lymphoproliferative disorders and now represents a significant breakthrough in treating relapsed/refractory and previously untreated patients with chronic lymphocytic leukemia (CLL). Because few systematic studies or comparative randomized clinical trials have been conducted, optimal use of zanubrutinib in approved indications may be challenging. This article presents the results of a group discussion among an ad hoc constituted panel of experts to identify and address unmet clinical needs (UCNs) in using zanubrutinib in patients with CLL. Key UCNs were selected according to the criterion of clinical relevance using the Delphi process. Panel members reviewed the results of first-line and upstream controlled trials in which the efficacy and toxicity profile of zanubrutinib and other BTK inhibitors were investigated in patients with CLL. Based on a critical discussion of data, the panel produced recommendations for using zanubrutinib and proposals for new studies to increase the evidence for the optimal treatment of patients with CLL. The recommendations given by the panel are intended for use not only by expert centers but, above all, by less experienced hematologists as well as general practitioners., (© 2024 John Wiley & Sons Ltd.)