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The article presents the author's views on the historical development of information infrastructures and the dissemination of knowledge. The author has published a number of historical studies examining utopian schemes for managing knowledge, the evolution of institutionalized or organizational aspects of information infrastructure, and the emergence of what he thinks of as an interdiscipline. The "Universe of Information: The Work of Paul Otlet for Documentation and International Organization" was an initial study of a hitherto neglected figure. A Russian translation of this book was published in 1977 and a Spanish edition in 1996. With the advent of the Internet and the Web, it has become clear how pioneering and important historically the work of Paul Otlet and his colleagues was. It seems yet even more relevant today with the recently announced agreement between Google and a number of research libraries to digitize and make their collections available through the Web. In Information Processing and Management, "Some Schemes for Restructuring and Mobilizing Information in Documents: A Historical Perspective," the author examines the utopian information management ideas of John Dury and Samuel Hartlib.

Atmospheric rivers (ARs) can provide as much as 50% of the total annual rainfall to the United States West Coast via orographic precipitation. Dust is thought to enhance orographic precipitation via the "seeder‐feeder" mechanism, in which ice particles from a high cloud fall through a lower orographic cloud, seeding precipitation in the low cloud. Using the Weather Research and Forecasting model, we vary dust concentrations in simulations of two‐dimensional flow over a mountain. This idealized framework allows us to test the sensitivity of the precipitation‐dust response to a variety of different dust concentrations and initial conditions. The model is run using an ensemble of 60 radiosondes collected from Bodega Bay, CA in 2017–2018, clustered based on their vertical moisture profile into "deep moist," "shallow moist," and "subsaturated" clusters. The principle impact on precipitation is to increase the ratio of precipitation falling as snow. This produces a "spillover" effect, decreasing precipitation upwind of the peak and increasing precipitation downwind of the peak. The largest impacts on the snow/rain ratio occur at the end of the event, during cold front passage. The ensemble mean does not produce a significant seeder‐feeder response, however, in individual cases with favorable initial conditions there is a significant increase in precipitation throughout the domain due to dust effects on the seeder‐feeder mechanism. These findings afford an opportunity to build a more comprehensive understanding for the conditions under which dust aerosol can have a significant impact on precipitation during ARs, with implications for future developments in forecasting. Key Points: Dust increases the percentage of precipitation falling as snow/graupel during landfalling atmospheric riversIncreases in dust tend to decrease orographic precipitation upwind of the peak and increase orographic precipitation downwind of the peakThe sensitivity of precipitation to dust depends on the initial thermodynamic structure of the atmosphere [ABSTRACT FROM AUTHOR]

Objective: Juvenile localized scleroderma (LS) is an autoimmune disease of the skin whose pathogenesis is not well understood due to the rarity of the disease. This study was undertaken to determine the skin transcriptome in skin biopsy tissue from children with juvenile LS compared to pediatric healthy controls, with identification of significant molecular targets using RNA sequencing (RNA‐Seq). In this study, differentially expressed genes (DEGs) were assessed for correlations with histopathologic and clinical features in children with juvenile LS, and were used to group the children into distinct genetic clusters based on immunophenotype. Methods: RNA‐Seq was performed on sections of paraffin‐embedded skin tissue obtained from 28 children with juvenile LS and 10 pediatric healthy controls. RNA‐Seq was carried out using an Illumina HTS TruSeq RNA Access library prep kit, with data aligned using STAR and data analysis using a DESeq2 platform. A standardized histologic scoring system was used to score skin sections for the severity of inflammation and levels of collagen deposition. Histologic scoring was completed by 2 pathologists who were blinded with regard to the status of each sample. Spearman's rank correlation coefficients were used to assess significant correlations between DEG expression profiles and skin histologic findings in patients with juvenile LS. Results: We identified 589 significant DEGs in children with juvenile LS as compared to healthy controls. Hierarchical clustering was used to demonstrate 3 distinct juvenile LS immunophenotype clusters. The histologic scores of skin inflammation (based on numbers and categories of inflammatory cell infiltrates) were significantly correlated with the expression levels of HLA–DPB1, HLA–DQA2, HLA–DRA, and STAT1 genes (rs > 0.5, P < 0.01). Collagen thickness correlated with the expression levels of collagen organization genes as well as with genes found to be correlated with the severity of inflammation, including genes for major histocompatibility complex (MHC) class I, MHC class II, and interferon‐γ signaling. Conclusion: Among children with juvenile LS, 3 distinct genetic signatures, or clusters, were identified. In one cluster, inflammation‐related pathways were up‐regulated, corresponding to the histologic skin inflammation score. In the second cluster, fibrosis‐related pathways were up‐regulated. In the third cluster, gene expression in the skin corresponded to the patterns seen in healthy controls. Up‐regulation of HLA class II genes was observed within the first cluster (characterized by predominant inflammation), a feature that has also been observed in the peripheral blood of patients with morphea and in the skin of patients with systemic sclerosis. [ABSTRACT FROM AUTHOR]

Well‐conducted systematic reviews are invaluable for synthesising research findings. The conclusions of a review depend on how the research question was formulated, how relevant studies were found and how studies were selected for synthesis.Here, we present a practical guide for ecologists and evolutionary biologists on formulating a question for a systematic review, and finding a representative sample of research findings.We explain the steps involved using a worked example and practical training exercises. Throughout this guide we share tricks of the trade, included rules of thumb and software that we have found useful.We hope our paper helps demystify the systematic search process and encourages more researchers to adopt a systematic and reproducible approach when searching the literature. [ABSTRACT FROM AUTHOR]

Regioselective hydrofunctionalization of alkynes represents a straightforward route to access alkenyl boronate and silane building blocks. In previously reported catalytic systems, high selectivity is achieved with a limited scope of substrates and/or reagents, with general solutions lacking. Herein, we describe a selective copper‐catalyzed Markovnikov hydrofunctionalization of terminal alkynes that is facilitated by strongly donating cyclic (alkyl)(amino)carbene (CAAC) ligands. Using this method, both alkyl‐ and aryl‐substituted alkynes are coupled with a variety of boryl and silyl reagents with high α‐selectivity. The reaction is scalable, and the products are versatile intermediates that can participate in various downstream transformations. Preliminary mechanistic experiments shed light on the role of CAAC ligands in this process. [ABSTRACT FROM AUTHOR]

Natural products (NPs), being evolutionary selected over millions of years to bind to biological macromolecules, remained an important source of inspiration for medicinal chemists even after the advent of efficient drug discovery technologies such as combinatorial chemistry and high‐throughput screening. Thus, there is a strong demand for efficient and user‐friendly computational tools that allow to analyze large libraries of NPs. In this context, we introduce NP Navigator – a freely available intuitive online tool for visualization and navigation through the chemical space of NPs and NP‐like molecules. It is based on the hierarchical ensemble of generative topographic maps, featuring NPs from the COlleCtion of Open NatUral producTs (COCONUT), bioactive compounds from ChEMBL and commercially available molecules from ZINC. NP Navigator allows to efficiently analyze different aspects of NPs ‐ chemotype distribution, physicochemical properties, biological activity and commercial availability of NPs. The latter concerns not only purchasable NPs but also their close analogs that can be considered as synthetic mimetics of NPs or pseudo‐NPs. [ABSTRACT FROM AUTHOR]

Introduction: Medicinal plants have been used in healthcare since time immemorial, as have their therapeutic activities and the production of plant‐based medicines. Objectives: This study aims to use gene‐targeted molecular markers for genetic diversity analysis of 16 medicinal plants. Besides, phytochemical analysis antibacterial and antifungal activities of some medicinal plant extracts commonly used in Egypt are compared to major compounds. Methods: DNA‐based classification of 16 medicinal species using Conserved DNA‐Derived Polymorphism (CDDP) and Start Codon Targeted (SCoT) primers. Three species representing three orders (Pelargonium graveolens, Matricaria chamomilla, and Hyoscyamus muticus were analysed [high‐performance liquid chromatography (HPLC), gas chromatography‐mass spectrometry (GC‐MS)] and evaluated for their antibacterial and antifungal activities against (Escherichia coli O157: H7 ATCC 93111, Salmonella typhimurium ATCC 14028, Methicillin‐resistant Staphylococcus aureus (MRSA) ATCC 43300, Bacillus ceruse ATCC 33018, and Sclerotinia sclerotiorum in comparison with some of their antimicrobial components. Results: Our results revealed 309 and 349 polymorphic bands with 100% polymorphism. Among them, 51 and 57 were unique loci for CDDP and SCoT, respectively. The 16 species were categorised into three groups depending on the similarity matrix. The results of antibacterial and antifungal activities revealed that Pelargonium oil showed significant antifungal and antibacterial activities against the tested pathogens. Gallic acid severely reduced all tested bacteria's growth, but atropine severely reduced the growth of the B. ceruse only. Molecular modelling revealed their activity against sclerotium development. Conclusion: The gene‐targeted marker techniques were highly useful tools for the classification of the 16 medicinal plant species, despite displaying high similarities at morphological and phytochemical analyses but, have antifungal and antibacterial activities. The sixteen species were categorized into 3 groups depending on the similarity matrix. The results of antibacterial and antifungal activities revealed that Pelargonium oil showed significant antifungal and antibacterial activities against the tested pathogens. Gallic acid severely reduced all tested bacteria's growth, but Atropine severely reduced the growth of the B. ceruse only. Molecular modelling revealed their activity against sclerotium development. The gene‐targeted marker techniques were highly useful tools for the classification of the 16 medicinal plant species. [ABSTRACT FROM AUTHOR]

The Cephaloscyllium ventriosum shark is present in the artisanal fisheries of elasmobranchs on the western coast of Baja California Sur, Mexico. The main characteristics of the sexual maturation of this species based on individuals captured from off north‐west Mexico in 2013–2016 are described. The size at maturity of this species was determined for the first time (total length 82 cm for females and 76 cm for males). Most females had one egg case per one uterus, and two per one uterus was an isolated event of low incidence. From the histological analysis of females, it was possible to show sperm storage in the oviducal gland. Fully developed sperm in immature organisms were identified in the testes. The main indicator of the maturity stage of males and their mating activity is the clasper. The present study provides evidence for a reliable estimation of the sexual maturity of these organisms, demonstrating the need for the combination of macroscopic and microscopic methods. [ABSTRACT FROM AUTHOR]

The heterolytic decomposition of tert‐butyl peroxyformate to tert‐butanol and carbon dioxide, catalyzed by pyridine, is a long‐known example of a reaction whose kinetics are strongly affected by solvent polarity. From DFT and ab initio methods together with the SMD implicit solvation model, an extension on the formerly accepted mechanism is proposed. This novel proposal involves the formation of a carbonic acid ester intermediate and its further decomposition, through an unreported pyridine‐mediated stepwise route. Computed barriers for this mechanism at DLPNO/CCSD(T)‐def2‐TZVP are in excellent agreement with experimental kinetic data across different solvents. Furthermore, the strong relationships between activation energies, geometric parameters in the transition state and the characteristics of the different solvents are also analyzed in depth. [ABSTRACT FROM AUTHOR]

River fish diversity is threatened by anthropogenic environmental alteration to landscapes. The early life‐history stages of fish play an important role in maintaining diversity and population recruitment and can be heavily influenced by landscape patterns. Information on temporal and spatial distribution patterns of fish eggs and larvae is also important for biodiversity conservation and management of fish resources.The Yangtze River possesses a high diversity of fishes, including many commercially important species. The economy along the lower reach of the river is well developed, and most of the area is experiencing high pressure from human impacts. This section of the Yangtze River connects with the largest freshwater lake in China at the upstream end and flows into the estuary at the downstream end. These two landscape features are likely to have a significant impact upon the spatial distributions of fish egg and larval assemblages.Environmental variables, fish eggs, and larval assemblages were sampled in three locations, at Hukou, Anqing, and Jingjiang, in the lower reach of the Yangtze River. The results suggest that the higher number of species and greater abundance in upstream sites reflect the critical function of connectivity of Poyang Lake with the river for fish recruitment in the lower Yangtze. The delayed bloom of larval fish, occurrence of estuarine species, and a lower species number and abundance of freshwater fish downstream reflect the influence of tidal intrusion from the estuary.This study highlights the value of maintaining natural river–lakes connectivity in the Yangtze River as a conservation measure. The connected river–lake system should be designated as a priority area for fish resource protection in the lower reach of the Yangtze River. We recommend further measures to break down barriers between the river and other lakes and to restore the natural lateral connectivity of the floodplain ecosystem. [ABSTRACT FROM AUTHOR]

Baroclinic seamount-trapped waves are thought to influence their surrounding ecosystem; however, trapped waves are not well-studied in near-equatorial settings, where stratification is strong and Burger numbers (...) are large. Motivated by observations, we use daily output (2005-2009) from the global Parallel Ocean Program Model (POP) to examine topographically trapped baroclinic waves around the Seychelles Plateau (S > 400) in the tropical Indian Ocean. These trapped waves are associated with velocity and temperature oscillations at periods of 15-16 days, similar to the dominant period of some equatorial Yanai waves. Energy flux maps using POP output suggest that quasi-biweekly equatorial Yanai waves excite trapped waves on the western and south-western flanks of the Seychelles Plateau, near the surface. The anticyclonic energy flux associated with the trapped wave extends vertically throughout the water column and around most of the plateau circumference, diminishing on the eastern flank of the plateau. This work highlights the role that equatorial planetary waves and trapped waves play in facilitating energy redistribution, dissipation, and mixing in the tropical ocean. [ABSTRACT FROM AUTHOR]

Significant wave height (SWH) stems from a combination of locally generated "wind-sea" and remotely generated "swell" waves. In the Northern and Southern Hemispheres, wave heights typically undergo a sinusoidal annual cycle, with larger SWH in winter in response to seasonal changes in high-latitude storm patterns that generate equatorward propagating swell. However, some locations deviate from this hemispheric-scale seasonal pattern in SWH. For example, in the California coastal region, local wind events occur in boreal spring and summer, leading to a wind speed (WSP) annual cycle with a distinct maximum in boreal spring and a corresponding local response in SWH. Here ocean regions with a WSP annual cycle reaching a maximum in late spring, summer, or early fall are designated as seasonal wind anomaly regions (SWARs). Intra-annual variability of surface gravity waves is analyzed globally using two decades of satellite-derived SWH and WSP data. The phasing of the WSP annual cycle is used as a metric to identify SWARs. Global maps of probability of swell based on wave age confirm that during the spring and summer months, locally forced waves are statistically more likely in SWARs than in surrounding regions. The magnitude of the deviation in the SWH annual cycle is determined by the exposure to swell and characteristics of the wave field within the region. Local winds have a more identifiable impact on Northern Hemisphere SWARs than on Southern Hemisphere SWARs due to the larger seasonality of Northern Hemisphere winds. [ABSTRACT FROM AUTHOR]

The authors present an analysis of bilingual reading textbooks published at the turn of the 20th century. The authors examined the kinds of opportunities for learning offered by bilingual reading textbooks developed for students in Cuba, Puerto Rico, and the Philippines in the aftermath of the Spanish–American War. The analysis revealed challenges to understanding related to both the content and the structure of these textbooks, as well as the coloniality of knowledge embedded in them. The historical record also reveals a rejection of the format and content from scholars and educational leaders, and the subsequent turn toward reading materials, which better reflected the everyday experiences of Cuban, Puerto Rican, and Filipinx children, albeit often monolingually rather than bilingually. Implications are offered for how contemporary literacy materials might support (bi)literacy development of bilingual students across the globe. [ABSTRACT FROM AUTHOR]

The origin of electrical activity accompanying volcanic ash plumes is an area of heightened interest in volcanology. However, it is unclear how intense an eruption needs to be to produce lightning flashes as opposed to "vent discharges," which represent the smallest scale of electrical activity. This study targets 97 carefully monitored plumes <3 km high from Sakurajima volcano in Japan, from June 1 to 7, 2015. We use multiparametric measurements from sensors including a nine-station lightning mapping array and an infrared camera to characterize plume ascent. Findings demonstrate that the impulsive, high velocity plumes (>55 m/s) were most likely to create vent discharges, whereas lightning flashes occurred in plumes with high volume flux. We identified conditions where volcanic lightning occurred without detectable vent discharges, highlighting their independent source mechanisms. Our results imply that plume dynamics govern the charging for volcanic lightning, while the characteristics of the source explosion control vent discharges. Plain Language Summary There are different types of electrical activity that occur within volcanic ash plumes. One well-known type is volcanic lightning, which creates the familiar flashes of visible light. Another, lesser-known type is called "vent discharges," which are tiny and invisible but create a peculiar signal known as continual radio frequency. Vent discharges are important because they sometimes occur very early in an eruption and may provide a way to give early warning of volcanic hazards. For this study, we used a specialized instrument called a lightning mapping array to measure the electrical activity during small eruptions at Sakurajima volcano. We explored when lightning flashes and vent discharges occurred during 97 different explosions. First, we found that the two types did not always happen in the same explosion, showing they are caused by different processes. Second, we found that vent discharges were more likely to occur when the explosive plume rose quickly, possibly because rock breakup and particles rubbing together create a static charge close to the vent. In contrast, lightning flashes occurred when the plume had high volume flux. These findings give clues about how to link electrical signals to eruptive processes for volcano monitoring. [ABSTRACT FROM AUTHOR]

This article is the first to identify and estimate developers' supply functions for real estate attributes. It introduces instruments that separate the demand side effects of real estate attributes and capture the nature of developers upon their initial business establishment into a two‐stage estimation model. We construct a unique data set by merging the data sets containing characteristics of projects and developers with the data set of new private nonlanded residential sales in Singapore. The study covers the period from January 1995 to March 2009. The supply functions for unit area and floor level are concave with developers' building experience, and convex with developers' business age. Developers enjoy marginal cost reductions on the two attributes after they have developed 1,000 or more units; and young developers have steeper "learning curve" than other developers. Old and experienced developers demonstrate less elasticity in their supply functions than young and inexperienced developers. This study provides new empirical evidence on corporate learning curve and knowledge diffusion processes with regard to the supply of real estate attributes. [ABSTRACT FROM AUTHOR]

Background: In the 121st anniversary year of the birth of Florence Nightingale, and during the COVID‐19 pandemic, it is both interesting and salient to be reminded of the foundational work of this famous woman who began modern nursing. Her work in nursing care and nursing, health and public policy has been a continuing strong foundation to practices in societies around the world. Methods: In this short communication about historical research, various aspects of Florence's life and work are described, as well as the locations, memorials and museum significant to our remembrance of her. Results: A particular focus of this paper is the description of a larger but little‐known medicine chest located at the College of Nursing, University of Saskatchewan, in Saskatoon, SK, Canada, and attributed as belonging to Florence. Conclusion: Best known to this point in time is a smaller medicine chest at the Florence Nightingale Museum in London. [ABSTRACT FROM AUTHOR]

The article presents information on oral history records at Columbia University. The Oral History material at Columbia University is housed in Special Collections of Butler Library, room 104, and is available for examination by qualified scholars on the premises only. It may not be reproduced, nor are we permitted, by the terms of agreement made with each donor, to loan the material to other institutions. About one third of the memoirs thus far obtained may not yet be examined by anyone, in most such cases until five years after the death of the authors.

This paper describes a distributed system called Distributed Seismic Unix (DSU). DSU provides tools for creating and executing application sequences over several types of multiprocessor environments. DSU is designed to assist geophysicists in developing and executing sequences of Seismic Unix (SU) applications in clusters of workstations as well as on tightly coupled multiprocessor machines. SU is a large collection of subroutine libraries, graphics tools and fundamental seismic data processing applications that is freely available via the Internet from the Center for Wave Phenomena (CWP) of the Colorado School of Mines. SU is currently used at more than 500 sites in 32 countries around the world. DSU is built on top of three publicly available software packages: SU itself; TCL/TK, which provides the necessary tools to build the graphical user interface (GUI); and PVM (Parallel Virtual Machine), which supports process management and communication. DSU handles tree-like graphs representing sequences of SU applications. Nodes of a graph represent SU applications, while the arcs represent the way the data flow from the root node to the lead nodes of the tree. In general the root node corresponds to an application that reads or creates synthetic seismic data, and the leaf nodes are associated with applications that write or display the processed seismic data; intermediate nodes are usually associated with typical seismic processing applications like filters, convolutions and signal processing. Pipelining parallelism is obtained when executing single-branch tree sequences, while a higher degree of parallelism is obtained when executing sequences with several branches. A major advantage of the DSU framework for distribution is that SU applications do not need to be modified for parallelism; only a few low-level system functions need to be modified. Copyright © 1999 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Objective: This piece outlines the historical contours of Confederate memorialization in the South, drawing attention to major types of monuments and the timing of their erection. It also identifies the agents of commemoration, groups who invested significant time and resources in forging the Lost Cause narrative, and sets these efforts within the context of broader patterns of historical memory and civic celebration throughout the South. Method: We review the scholarly literature across disciplines on Confederate memorialization and tease out themes of group agency, memory and identity, cultural narrative, and symbolism. Results: We reveal a periodization of memorialization marked by key moments and events, a systematic effort by civic associations, a typology of monuments, a deployment of neoclassical style in service to Lost Cause culture, and a lingering reference to Civil War era flags and symbols. Conclusion: Providing context for examination of Confederate memorialization in the South grounds academic and popular discourse on these public spaces as tools of racial marginalization and scenes of political contestation. [ABSTRACT FROM AUTHOR]

A compilation is made of the largest and second‐largest magnetic‐storm‐maximum intensities, −Dst1 and −Dst2, for solar cycles 14–24 (1902–2016) by sampling Oulu Dcx for cycles 19–24, using published −Dstm values for 4 intense storms in cycles 14, 15, and 18 (1903, 1909, 1921, 1946), and calculating 15 new storm‐maximum −Dstm values (reported here) for cycles 14–18. Three different models are fitted to the cycle‐ranked −Dst1 and −Dst2 values using a maximum‐likelihood algorithm: A Gumbel model, an unconstrained Generalized‐Extreme‐Value model, and a Weibull model constrained to have a physically justified maximum storm intensity of −Dstm = 2500 nT. All three models are good descriptions of the data. Since the best model is not clearly revealed with standard statistical tests, inference is precluded of the source process giving rise to storm‐maximum −Dstm values. Of the three candidate models, the constrained Weibull gives the lowest superstorm occurrence probabilities. Using the compiled data and the constrained Weibull model, a once‐per‐century storm intensity is estimated to be −Dst1 = 663 nT, with a bootstrap 68% confidence interval of [497, 694] nT. Similarly, the probability that a future storm will have an intensity exceeding that of the March 1989 superstorm, −Dstm > 565 nT, is 0.246 per cycle with a 68% confidence interval of [0.140, 0.311] per cycle. Noting (possibly slight) ambiguity in the rankings of storm intensities, using the same methods, but storms more intense than those identified for cycles 14–16, would yield a higher once‐per‐century intensity and a higher probability for a −Dstm > 565 nT storm. Plain Language Summary: Past and possible future magnetic storm intensities are investigated. As part of this work, a dataset is developed of the most intense and second most intense storms for each of the past 11 solar cycles (1902–2016)—augmenting a traditional dataset that only covers the past 6 solar cycles (1957–2016) with recently published intensities for several magnetic superstorms and with new storm intensity estimates, reported here and derived from historical magnetic observatory records. These data are analyzed using statistical methods that provide estimates of the probability of future magnetic superstorms. A storm as intense as that of March 1989, which caused widespread disruption of technological systems and an electricity blackout in Québec, Canada, is predicted to occur, on average, about every four solar cycles. This is twice as often as estimated using only the traditional shorter dataset. A once‐per‐century storm is estimated to be substantially more intense than that of March 1989. Key Points: Magnetic‐storm‐maximum −Dstm, ranked per solar cycle, are well represented by a Weibull modelBased on geomagnetic data for solar cycles 14–24 yields, a 100‐year storm has an intensity of at least −Dstm = 663 nTBased on geomagnetic data for solar cycles 14–24, the average return rate for a storm as intense as March 1989 (−Dstm = 565 nT) is less than 4.1 solar cycles [ABSTRACT FROM AUTHOR]

Aim: There may exist a gap between the current form of traditional Japanese Kampo pediatrics and Kampo pediatrics in the nineteenth century. This study aimed to elucidate changes in clinical practice by comparing the formulas used then and now. Methods: All formulas described in Yoyokasoku (In‐house Methods of Pediatrics [IMP], a Kampo classic published in 1885) and formulas used in a contemporary pediatric Kampo guideline were extracted. Then, a database with annotations to formulas was compiled. Results: In all, 387 formulas (274 excluding duplications) and 10 methods of moxibustion/surgical treatments were extracted from IMP. The total number of classical formulas described was 72. The proportion of classical formulas was significantly different among disease clusters (P < 0.0001). Overall, the contemporary Kampo guideline used classical formulas in any type of disease, and the proportion of this usage was significantly higher than that in IMP (59% vs. 19%, P < 0.0001). IMP described 95 Japanese original formulas (25%) including 45 in‐house formulas. However, none of them have been implemented in the contemporary guideline. Conclusion: Current Kampo pediatrics may have developed less under the influence of a pediatric classic in the nineteenth century; however, a thorough investigation of pediatric books is needed to understand the history of Kampo pediatrics. [ABSTRACT FROM AUTHOR]

The late 1960s to the mid‐1980s in Britain was a period of intense industrial struggle, with strike levels at their highest since the 1920s. Concerns surrounding trade union power became central to broader anxieties about British "decline" and "crisis." These issues took a spatial form in conflicts around the nature of the picket line. This paper discusses the picket line in 1970s Britain in the context of recent debates on the geographies of violence, particularly in relation to questions of class and property, and the mutually constitutive temporalities of structural and direct violence. Rather than focusing on the diffuse processes of an abstract capitalism, I argue for greater attention to be paid to class conflict in shaping experiences and epistemologies of violence. This paper therefore places more emphasis on agency in the production of violence than has been prevalent in recent debates in geography. Drawing on extensive archival research, the paper focuses on three key disputes in this period. Building on work in labour geography, it explores how the assertive working‐class presence of mass pickets were portrayed as violent through an account of the miners' strike in 1972. It then considers a similar process in relation to flying pickets during the 1972 builders' dispute, emphasising the threat of a politicised working‐class mobility. Finally, the paper considers the coercive state response in the violent policing of the picket line during the 1976–8 Grunwick dispute. The radical right‐wing project of neoliberalism emerged in part as a solution to the perceived threat of the labour movement; critical to its success and consolidation was challenging the "enemy within" of militant trade unionism. These violent class struggles around picketing in the 1970s, I argue, are crucial for understanding the long‐term, structural violence of neoliberalism. This paper discusses the picket line in 1970s Britain in the context of recent debates on the geographies of violence, particularly in relation to questions of class and property, and the mutually constitutive temporalities of structural and direct violence. Through accounts of the 1972 miners' and builders' strikes, and the 1976–1978 Grunwick dispute, the paper explores the mass picket, the flying picket, and police violence. Rather than focusing on the diffuse processes of an abstract capitalism, I argue for greater attention to be paid to class conflict in shaping experiences and epistemologies of violence. [ABSTRACT FROM AUTHOR]

The ethnological collecting expeditions conducted by museums in the nineteenth and twentieth centuries have had impacts on source communities and on the composition and interpretation of museum collections that have been critically examined from a number of perspectives. Although categories such as ethnicity and tribal affiliation are now understood to be situational, relational, and contingent, systems of classification in museums remain in large part rigid and immutable. Concrete approaches to addressing these issues in museum collections have been slower to emerge. This article presents an approach to the description of objects, influenced by attribute analysis and thick description, that has the potential to make salient information about museum collections more accessible to source communities. With two case studies (parfleches and moccasins from the Great Plains collections at the American Museum of Natural History), this article demonstrates how collaborative object‐centered inquiry can help to disentangle objects from historical systems of classification in museum settings and "remobilize" them. Moving beyond classification to document the cultural practices documented in historical material culture can aid in reconstructing the complex movements of people, objects, and ideas in the past. [ABSTRACT FROM AUTHOR]

With oceans covering 71% of the Earth's surface, sea spray aerosol (SSA) particles play an important role in the global radiative budget by acting as cloud condensation nuclei and ice nucleating particles (INPs). By acting as INPs, SSA particles affect the structure and properties of mixed‐phase clouds by inducing freezing at warmer temperatures than the homogeneous freezing temperature. Climate models that incorporate marine INPs use the emission of submicron SSA in INP parameterizations because these particles contain a higher fraction of organic mass. Here we show supermicron SSA particles, produced using a natural breaking wave analogue, are the major source of INPs throughout the lifecycle of a phytoplankton bloom. Additionally, supermicron SSA particles are shown to be more efficient INPs than submicron SSA particles, because they carry a greater number of ice active components. Thus, supermicron SSA needs to be incorporated in INP parameterizations for future climate models. Plain Language Summary: Clouds over high latitude oceans are a major source of uncertainty in global climate models. Sea spray aerosol (SSA) particles are the dominant source of cloud seeds over remote marine locations. Ice nucleating particles (INPs) initiate cloud freezing. Previous climate models approximated INPs released from oceans using the number of submicron SSA. However, field studies show supermicron particles are effective INPs over marine locations. This study was designed to understand the role of particle size for marine INPs in an isolated ocean/atmosphere laboratory setting. Two phytoplankton blooms were induced in seawater and a breaking wave proxy generated SSA. The ice nucleating activities of SSA particles in two size‐segregated populations were measured. Throughout both blooms, supermicron SSA particles were the most ice active population. The efficiency of supermicron particles was still apparent after normalizing to particle surface area. Following normalization to aerosol volume, submicron and total particle populations were comparable, suggesting ice active components in SSA scale with particle volume in the observed temperature range (−26°C to −8°C). These results suggest that climate models use size‐dependent INP activities for SSA. Proper representation of marine INPs will increase model accuracy of ice content in clouds and radiative forcing over high latitude oceans. Key Points: Supermicron sea spray aerosols have higher ice nucleating particle (INP) concentrations at warm temperatures than submicron sea spray aerosolsThe higher concentrations of INPs in supermicron sea spray aerosols occur independent of phytoplankton bloom stateThe ice nucleating ability of a sea spray aerosol (SSA) is roughly proportional to the dry particle volume [ABSTRACT FROM AUTHOR]

Observations of surface waves and ice drift along a compact sea ice edge demonstrate the importance of waves in a marginal ice zone. An analytic model is presented for the along‐ice drift forced by the radiation stress gradient of oblique waves. A momentum balance using quadratic drag to oppose the wave forcing is sufficient to explain the observations. Lateral shear stresses in the ice are also evaluated, though this balance does not match the observations as well. Additional forcing by local winds is included and is small relative to the wave forcing. However, the wave forcing is isolated to a narrow region around 500‐m wide, whereas the wind forcing has effects on larger scales. The simplistic drag is assessed using observations of shear and turbulent dissipation rates. The results have implications for the shape and evolution of the ice edge, because the lateral shear may be a source of instabilities. Plain Language Summary: Ocean surface waves rapidly get smaller when traveling from open water into sea ice. Although waves in sea ice do not break, there are some similarities to waves traveling through the surf zone, which lose most of their energy and momentum before reaching the shore. Here, the wave momentum is transferred to the sea ice and can cause strong ice drift. In the case of waves arriving at an oblique angle to the ice edge, the ice drift is directed along the ice edge, similar to alongshore currents in the surf zone. Continuing the surf‐zone analogy, the wave energy is transferred into turbulence below the water (ice) surface. Finally, there are fluctuations in the ice edge shape that may be related to this wave forcing. Key Points: Obliquely propagating surface waves drive flow (ice drift) along a marginal ice zoneGradients in the waves provide the momentum for the ice drift, which is opposed by ice‐ocean stress in a simple modelInstabilities in the strongly sheared ice drift may cause fluctuations in the ice edge shape [ABSTRACT FROM AUTHOR]

Benzylisoquinoline alkaloids (BIAs) have profound implications on human health owing to their potent pharmacological properties. Notable naturally occurring BIAs are the narcotic analgesics morphine, the cough suppressant codeine, the potential anticancer drug noscapine, the muscle relaxant papaverine, and the antimicrobial sanguinarine, all of which are produced in opium poppy (Papaver somniferum). Thebaine, an intermediate in the biosynthesis of codeine and morphine, is used in the manufacture of semisynthetic opiates, including oxycodone and naloxone. As the only commercial source of pharmaceutical opiates, opium poppy has been the focus of considerable research to understand BIA metabolism in the plant. The elucidation of several BIA biosynthetic pathways has enabled the development of synthetic biology platforms aimed at the alternative commercial production of valuable phytochemicals in microorganisms. The detection and identification of BIA pathway products and intermediates in complex extracts is essential for the continuing advancement of research in plant specialized metabolism and microbial synthetic biology. Herein, we report the use of liquid chromatography coupled with linear trap quadrupole and high-resolution Orbitrap multistage mass spectrometry to characterize 44 authentic BIAs using collision-induced dissociation (CID), higher-energy collisional dissociation (HCD), and pulsed Q collision-induced dissociation (PQD) MS² fragmentation, with MS² CID followed by MS³ and MS4 fragmentation. Our deep library of diagnostic spectral data constitutes a valuable resource for BIAs identification. In addition, we identified 22 BIAs in opium poppy latex and roots extracts. [ABSTRACT FROM AUTHOR]

Numerous books and papers have been written about the life and work of the famous Leiden physician and botanist professor Herman Boerhaave (1668–1738). However, none of these publications mentions what has happened to his botanical collections. A set of loose herbarium sheets with labels written by Boerhaave is known to be present at Naturalis Biodiversity Center, Leiden. Furthermore, two bound herbaria attributed to Boerhaave are known to exist. The first, a four‐volume herbarium makes part of the Sloane Herbarium (Natural History Museum, London). The second is a voluminous one‐volume herbal at Copenhagen (Natural History Museum Denmark). Another single‐volume herbarium, traditionally referred to as the "Herbarium of Boerhaave", at Leiden (Naturalis) is discussed here as well. Are these true Boerhaave herbaria made by Boerhaave personally, or have these herbaria at least formed part of his private collection? Where could other herbaria of his be found, and what has happened to the herbaria that were auctioned together with his library after his death? These are the questions this paper will try to answer. [ABSTRACT FROM AUTHOR]

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Selenium NMR has become a standard tool for scaling the π‐accepting character of carbenes. Herein, we highlight that non‐classical hydrogen bonding (NCHB), likely resulting from hyperconjugation, can play a significant role in the carbene–selenium 77Se NMR chemical shift, thus triggering a non‐linear behavior of the Se‐Scale. [ABSTRACT FROM AUTHOR]

Genealogies of life assurance have tended to focus on the governmental possibilities of actuarial calculations of mortality, but the case of foreign residence assurance draws attention to other ways in which British companies calculated climate risk between 1840 and 1940. Drawing on archival research, this paper demonstrates that the extra charges imposed on life assurance policies for foreign residence invited conversations about the risks of climate and mortality in countries beyond Britain, drawing on both contemporary climate science and other arguments about climate pathology. Climate risks, however, had to be made to work for both life assurers and policyholders through far‐reaching social‐material networks, and firms frequently tinkered with arrangements of people, ideas, and artefacts in ways that enabled a mapping and governing of such risks. Whether ideas of climate circulating in life assurance were believed or not, they had effects and policyholders submitted to them. Drawing on archival material from several British life assurance companies, including some detailed cases of assured migrant lives, the paper explores how companies made risk calculations in ways that had consequences for ordinary decisions and practices. In so doing, the paper contributes to debates about life assurance and governmentality, showing that foreign residence policies enabled businesses to secure their risks in an era of imperial expansion. But this is no simple story of power and imperialism. Businesses constantly tinkered with their policies, drawing on climate science and medical understandings, but only as part of an always messy, changing assemblage. [ABSTRACT FROM AUTHOR]

The article focuses on the archive collection at the University of New Hampshire (UNH) of memorabilia associated with the 1961 reported alien abduction of Eunice "Betty" (Barrett) Hill and Barney Hill. Of particular interest is the stained blue dress worn by Betty that night and drawings of an unidentified flying object (UFO).

Today, parents are warned to protect their children from the sun's ultraviolet (UV) rays, the most preventable and leading cause of skin cancer. Yet, during the first half of the 20th century, the medical community widely extolled the health benefits of daily sunbaths for babies and children. What initially had begun as evidence‐based medical therapies to prevent pediatric diseases, specifically tuberculosis and rickets, soon took on a life of its own as physicians, public health experts, and the general public embraced sunbathing and tanning as a means to ensure health and wellbeing for children and families. Here, we trace how specific medical therapies entered mainstream pediatric medicine and, converging with societal and cultural forces, shaped attitudes and behaviors towards sunbathing that still exist today. Understanding our complex history with the sun may shed light on the current peak of skin cancer incidence and future disease development. Moreover, it may help improve how we educate parents and children about sun safety by taking into account the current social and cultural context of medical practice and health communication. [ABSTRACT FROM AUTHOR]

Conventional intensification of agriculture has reduced the availability of resources for pollinators, reducing their diversity and affecting plant pollination, both in natural habitats and croplands. Field margin floral enhancements such as flower strips or restored field margins could counteract these negative effects.The approaches to assess the success of these management measures generally evaluate separately the pollinator response at the edge and within the crop, as proxies for pollinator conservation and pollination services, respectively.We performed a meta‐analysis to understand the influence of field margin floral enhancements on the abundance and richness of pollinators at the edge and within the field, and on crop yield.We estimated 137 effect sizes from 40 studies, all from the northern hemisphere. Overall, the field margin floral enhancements increased the abundance and richness of pollinators at the field edge but had no consistent effect in the interior of the crop fields. Few studies evaluated crop yield, and in these studies no effects were observed.These results suggest that field margin floral enhancements can constitute a positive conservation action for pollinators but not necessarily associated with pollination ecosystem service. [ABSTRACT FROM AUTHOR]

This project compiled 463,530 instrumental observations of daily temperature, precipitation and sunshine at up to 319 stations in China between 1912 and 1951. The principal sources are monthly reports of the Institute of Meteorology, Nanjing, observatories in Japanese‐occupied Manchuria, and the Japanese Army in North China. Gross errors, rounding errors and inhomogeneities are identified. The new dataset is temporally and spatially consistent with existing datasets of monthly temperature, but reports higher precipitation and sunshine. [ABSTRACT FROM AUTHOR]

This article analyses the presentation of the Commons' Speaker in the Tudor age. It traces the medieval origins of this ceremony, arguing that it served not only as an opportunity for flamboyant rhetoric, but also as a politically significant event designed to impress upon the Commons its inferiority in the parliamentary hierarchy. The article also suggests that Elizabethan Speakers used their orations as a means of presenting counsel to the queen herself. [ABSTRACT FROM AUTHOR]

Fragment‐based drug discovery (FBDD) has become an established approach for the generation of early lead candidates. However, despite its success and inherent advantages, hit‐to‐candidate progression for FBDD is not necessarily faster than that of traditional high‐throughput screening. Thus, new technology‐driven library design strategies have emerged as a means to facilitate more efficient fragment screening and/or subsequent fragment‐to‐hit chemistry. This minireview discusses such strategies, which cover the use of labeled fragments for NMR spectroscopy, X‐ray crystallographic screening of specialized fragments, covalent linkage for mass spectrometry, dynamic combinatorial chemistry, and fragments optimized for easy elaboration. [ABSTRACT FROM AUTHOR]

Essential genes tend to be highly conserved across eukaryotes, but, in some cases, their critical roles can be bypassed through genetic rewiring. From a systematic analysis of 728 different essential yeast genes, we discovered that 124 (17%) were dispensable essential genes. Through whole‐genome sequencing and detailed genetic analysis, we investigated the genetic interactions and genome alterations underlying bypass suppression. Dispensable essential genes often had paralogs, were enriched for genes encoding membrane‐associated proteins, and were depleted for members of protein complexes. Functionally related genes frequently drove the bypass suppression interactions. These gene properties were predictive of essential gene dispensability and of specific suppressors among hundreds of genes on aneuploid chromosomes. Our findings identify yeast's core essential gene set and reveal that the properties of dispensable essential genes are conserved from yeast to human cells, correlating with human genes that display cell line‐specific essentiality in the Cancer Dependency Map (DepMap) project. Synopsis: A systematic analysis of 728 different essential yeast genes identifies 124 (17%) dispensable essential genes. Whole‐genome sequencing is used to identify the genome alterations underlying the bypass suppression. Dispensable essential genes show distinct properties that can be used to predict essential gene dispensability and are conserved from yeast to human cells.Bypass suppressors often show a strong functional connection to the dispensable essential gene, which can be used to predict suppressor genes.Dispensable essential genes can generally only be suppressed by a single genetic mechanism, including aneuploidies and mutations in specific suppressor genes, which involve both loss‐of-function and gain‐of-function alleles.A list of 805 core essential genes is defined that are either absolutely required for cell viability in yeast or only suppressed by highly complex genetic mechanisms. [ABSTRACT FROM AUTHOR]

This paper uses mixed methods to scavenge and analyse lesbian, gay, bisexual, trans, queer and two‐spirit (LGBTQ2S) resources and visibility in public library branches on the periphery of the Vancouver city‐region in the suburban municipalities of Surrey, Burnaby, and New Westminster. It argues that in Canadian suburbs, where access to LGBTQ2S community resources are limited, libraries are simultaneously key public sites of engagement for LGBTQ2S people and places where they continue to face dominant socio‐cultural power relations of hetero and cis‐normativity that determine the availability, visibility, and accessibility of queer materials. Scavenging for queerness within virtual and material library spaces, this paper demonstrates that suburban libraries hold the promise of information and equity while also reinforcing LGBTQ2S absence, invisibility, and exclusion. The promise of social inclusion is carried forward by a few insider activist and ally librarians who act as political change agents within library systems and specific branches by creating queer‐friendly collections, spaces, and programming. [ABSTRACT FROM AUTHOR]