1. Catalytic Asymmetric Synthesis of Phosphine Boronates.
- Author
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Hornillos, Valentín, Vila, Carlos, Otten, Edwin, and Feringa, Ben L.
- Subjects
ENANTIOSELECTIVE catalysis kinetics ,ASYMMETRIC synthesis ,BORONIC esters ,PHOSPHINE oxides ,ORGANOPHOSPHORUS compounds ,HOMOGENEOUS catalysis ,LEWIS pairs (Chemistry) - Abstract
The first catalytic enantioselective synthesis of ambiphilic phosphine boronate esters is presented. The asymmetric boration of α,β-unsaturated phosphine oxides catalyzed by a copper bisphosphine complex affords optically active organoboronate esters that bear a vicinal phosphine oxide group in good yields and high enantiomeric excess. The synthetic utility of the products is demonstrated through stereospecific transformations into multifunctional optically active compounds. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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