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Objectives: Pharmaceutical manufacturers recommend refrigerating succinylcholine at a temperature range of 2–8°C. With widespread use of prehospital succinylcholine on ambulances without refrigeration, it is important to understand the stability of this drug. Using mass spectrometry, this study investigated the degradation of the succinylcholine compound before and after its exposure to ambulance cabin temperatures, while removing light exposure. A 10% degradation threshold was set as not appropriate for human use, in accordance with U.S. Food and Drug Administration guidelines. Methods: The study used 17 vials of succinylcholine sealed with duct tape in light-resistant bags. The bags were placed in climate controlled compartments in two ambulances: one stationed in a garage and the other stationed outdoors. Mass spectrometry analysis was used to examine drug degradation at Time 0, the 14th day of the first month, and monthly from Time 0 to 7 months. Results: The degradation products of succinyl monocholine (SMC) and choline are already present at Day 0. Ten percent degradation was achieved at approximately 90 days into the experiment. Temperature in the ambulance climate controlled compartment was 70°F, with a range from 56 to 89°F during the 6-month time period. Conclusions: Identifiable breakdown fragments of succinylcholine have been identified using mass spectrometry with fresh drug upon receipt from the manufacturer. Ten percent degradation was not observed until approximately 90 days after being placed on ambulances. Temperature variations did not significantly contribute to degradation of succinylcholine, and it is safe for injection until approximately 90 days in similar climates. ACADEMIC EMERGENCY MEDICINE 2010; 17:631–637 © 2010 by the Society for Academic Emergency Medicine [ABSTRACT FROM AUTHOR]

Much of the difficulty associated with identifying and repatriating deceased undocumented border-crossers stems from an inability to narrow down the search area to more probable options. Analysis of the isotopic variation in the tooth enamel of modern Mexican populations is currently underway at the University of California Santa Cruz. Using Thermo Ionization Mass Spectrometry, the pilot research analyzed strontium isotopes located in the donated permanent teeth of Mexican-born individuals of known origin from four states. The preliminary results reveal the formation of three distinctly significant regions in the data set. Using the technology outlined here, a map documenting the isotopic variation in modern Mexican tooth enamel is being complied to use for cross comparison with deceased border crossers of unknown origin. [ABSTRACT FROM AUTHOR]

Information about the annual American Society of Mass Spectrometry meeting held in Minneapolis, Minnesota on June 9 to 13, 2013 is presented. Topics include the embryonic playground of editorial creativity. The meeting featured several representatives of the Associate Editorial Board including David Kilgour of Great Britain, Adam Trevitt of Australia and Sarah Trimpin of the U.S.

The article reports on the effectiveness of cavity ring-down spectroscopy in carrying out isotope analysis in the U.S. It reveals that the process, developed by chemists at Stanfod University, has utilized cavity ring-down spectrometer which enable researchers to effectively evaluate isotope ratios, compared to isotope rate mass spectrometry (IRMS). Also, the instrument is inexpensive and has enhanced absorption rate.