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The first five points in Savic et al Table 1 describe unambiguous non-allergic manifestations, patients with no personal history of penicillin allergy or patients who have tolerated penicillin after the presumed allergic reaction.[1] These patients do not warrant further allergy work-up,[[2], [4]] and the penicillin allergy label can and should be removed without further investigations. Towards a safe and efficient de-labelling penicillin allergy service by non-allergists Keywords: allergens; clinical immunology; drug allergy; epitopes; IgEimmunologic tests EN allergens clinical immunology drug allergy epitopes IgEimmunologic tests 378 379 2 03/15/23 20230301 NES 230301 To the Editor, We read with great interest the 'BSACI guideline for the set-up of penicillin allergy de-labelling services by non-allergists working in a hospital setting' by Savic et al.[1] which provides guidance on evaluation and testing of patients with a possibly erroneous penicillin allergy label. [Extracted from the article]