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Non‐local self‐similar patch‐based denoising techniques have been viewed as the most popular denoising approaches in computer vision. This study has proposed a novel iterative weighted sparse representation (IWSR) scheme for X‐ray cardiovascular angiogram image denoising. The main procedures of this scheme include four parts. First, a maximum a posterior (MAP) distribution by the Bayes' theory is adopted to simultaneously estimate the estimated image and sparse representation with different Gaussian distributions approximating to likelihood prior, non‐local self‐similar patch prior and sparse representation prior. Second, the MAP problem is converted to minimise an energy function using the logarithmic transformation. Third, the function is efficiently solved by the single and effective alternating directions method of multipliers algorithm along with singular value decomposition (SVD) algorithm. Finally, owing to learned dictionary by K‐SVD algorithm, the qualitative and quantitative results of widely synthetic experiments demonstrate that the proposed IWSR denoising method performs effectively and can obtain competitive denoising performance and high‐quality images compared with those advanced denoising methods. The results of extensive experiments on clinical X‐ray angiogram images further illustrate that the IWSR method performs well on noise reduction and vascular structures including edges and capillaries preservation, integral cardiovascular trees of which are beneficial for clinicians to diagnose and analyse cardiovascular diseases. [ABSTRACT FROM AUTHOR]

Purpose: Recent efforts in the reconstruction of interventional devices from two distinct views require the segmentation of the object in both fluoroscopic images. Noise might decrease the quality of the segmentation and cause artifacts in the reconstruction. The noise level depends on the x-ray dose the patient is exposed to. The proposed algorithm reduces the noise and enhances the separability of curvilinear devices in background subtracted fluoroscopic images to allow a more accurate segmentation. Methods: The algorithm uses a set of binary masks to estimate a line conformity measure that determines the best direction for a directional filter kernel. If the calculated value exceeds a certain threshold, the directional kernel is used to obtain the filtered value. Otherwise, an isotropic filter kernel is used. Results: The evaluation was performed on a set of 36 fluoroscopic images using a vascular head phantom with three different guidewires and nine different x-ray dosages from 6 nGy/pulse to 45 nGy/pulse as well as a clinical data set containing ten images. Compared with wavelet shrinkage and the bilateral filter, the proposed algorithm increased the average contrast to noise ratio by at least 17.8% for the phantom and 68.9% for the clinical images. The accuracy of the device segmentation was improved on average by at least 17.3% and 14.0%, respectively. Conclusions: The proposed algorithm was able to significantly reduce the amount of noise in the images and therefore increase the quality of the device segmentations compared to both the bilateral filter and the wavelet thresholding approach for all acquired noise levels using rotating directional filter kernels near line structures and isotropic kernels for the background. The application of the proposed algorithm for the 3D reconstruction of curvilinear devices from two views would allow a more accurate reconstruction of the device. [ABSTRACT FROM AUTHOR]