3 results
Search Results
2. Association between the Oxytocin Receptor Gene Polymorphism (rs53576) and Bulimia Nervosa.
- Author
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Kim, Youl‐Ri, Kim, Jeong‐Hyun, Kim, Chan‐Hyung, Shin, Jae Gook, and Treasure, Janet
- Subjects
ANOREXIA nervosa ,BLOOD testing ,BULIMIA ,ALLELES ,ANALYSIS of variance ,APPETITE ,BODY weight ,CHI-squared test ,CHROMOSOMES ,CONFIDENCE intervals ,DIAGNOSTIC errors ,DNA ,GENETIC polymorphisms ,GOODNESS-of-fit tests ,CLASSIFICATION of mental disorders ,OXYTOCIN ,POLYMERASE chain reaction ,PSYCHOLOGICAL tests ,QUESTIONNAIRES ,RESEARCH funding ,STATISTICAL hypothesis testing ,STATISTICS ,T-test (Statistics) ,SAMPLE size (Statistics) ,DATA analysis ,BODY mass index ,CONTROL groups ,IN vitro studies ,ODDS ratio ,GENOTYPES ,DISEASE risk factors - Abstract
Objective Oxytocin circuits are implicated in the regulation of appetite and weight. Variants in the oxytocin receptor (OXTR) gene have been associated with bulimic behaviour. This study aimed to investigate the association between the OXTR gene and eating disorders. Method We genotyped six single nucleotide polymorphisms, rs53576, rs237879, rs2228485, rs13316193, rs2254298 and rs1042778, located within the OXTR gene in Korean patients with eating disorders using the single-base extension method. We studied a total of 262 women, including 69 patients with anorexia nervosa, 90 patients with bulimia nervosa (BN), and 103 healthy women. Results We found a positive association between the G allele of OXTR rs53576 and BN. In the BN group, the G carriers showed a high score on the behavioural inhibition system. Conclusions These findings suggest the involvement of the oxytocinergic system in the mechanism that underlies BN. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
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3. Periodontitis could be related factors on metabolic syndrome among Koreans: a case-control study.
- Author
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Han, Dong-Hun, Lim, Sinye, Paek, Domyung, and Kim, Hyun-Duck
- Subjects
ANALYSIS of variance ,CHI-squared test ,CONFIDENCE intervals ,EPIDEMIOLOGY ,INFLAMMATION ,INTERVIEWING ,METABOLISM ,PERIODONTITIS ,QUESTIONNAIRES ,SCALE analysis (Psychology) ,SYNDROMES ,MATHEMATICAL variables ,LOGISTIC regression analysis ,SAMPLE size (Statistics) ,DATA analysis ,INTER-observer reliability ,CASE-control method - Abstract
Aim: Several studies have suggested that metabolic disorders are related to periodontitis. The objective of this study is to assess whether periodontitis is associated with the metabolic syndrome ( MetS) among Koreans. Material and Methods This case-control study was performed among 167 cases with MetS and 166 healthy controls from Shiwha- Banwol Environmental Health Cohort ( N = 1853). The community periodontal index ( CPI) was used to assess periodontitis ( CPI 3-4). MetS was an outcome variable and periodontitis was a main explanatory variable. Age-gender-matched conditional logistic regression models were applied. Monthly household income, smoking, drinking, physical activity and diabetes mellitus were factored as confounders. We also performed stratified analyses according to confounders. Results Those with periodontitis are more likely to be patients with MetS than those without periodontitis. The adjusted odds ratio of periodontitis for MetS was 1.76. There was no significant dose-effect response on the relationship between the number of sextants with periodontitis and MetS. Links became higher in adults aged 45-60 years and adults without diabetes mellitus. Conclusions These results suggest that periodontitis could be an independently related factor on MetS. Hence, dentists and physicians should be aware of the importance of periodontitis as a potential source of inflammatory burden. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
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