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The objective of this study was to synthesize and coat a biocompatible polyvinylpyrrolidone polymer with pendent functional groups capable of forming triazole functionality onto surface of polyvinylchloride (PVC) and evaluate the modified surface. The coated surfaces were assessed with cell adhesion, bacterial adhesion and bacterial viability. Mouse fibroblast (NIH‐3 T3) cells and three bacteria species were used to assess surface adhesion and antibacterial activity. Results showed that the coated surface not only exhibited significantly reduced cell adhesion with a 65–85% decrease to 3 T3 fibroblast but also showed significantly reduced bacterial attachment with 52–76%, 45–66%, and 45–69% decrease to Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, respectively, as compared to original PVC. Furthermore, the polymer‐coated PVC surface exhibited a significant antibacterial function by inhibiting bacterial growth with reduction of 77–90%, 55–87%, and 55–92% to S. aureus, E. coli, and P. aeruginosa, respectively, as compared to original PVC. These results indicate that covalent polymer attachment enhanced antibacterial and antifouling properties to the PVC surface. [ABSTRACT FROM AUTHOR]

Surfaces with antibacterial and hydrophilic properties are very attractive to cardiovascular applications. The objective of this study was to synthesize and immobilize a novel antibacterial and hydrophilic polymer onto surface of polyvinylchloride via an effective and mild surface coating technique. The surface coated with a terpolymer constructed with N‐vinylpyrrolidone, 3,4‐dichloro‐5‐hydroxy‐2(5H)‐furanone derivative, and succinimide residue was evaluated with cell adhesion, bacterial adhesion, and bacterial viability. 3T3 mouse fibroblast cells and two bacteria species were used to evaluate surface adhesion and antibacterial activity. Results showed that the polymer‐modified polyvinylchloride surface exhibited not only significantly decreased 3T3 fibroblast cell adhesion with a 66% to 87% reduction but also significantly decreased bacterial adhesion with 69% to 87% and 52% to 74% reduction of Pseudomonas aeruginosa and Staphylococcus aureus attachment, respectively, as compared with original polyvinylchloride. Furthermore, the modified polyvinylchloride surfaces exhibited significant antibacterial functions by inhibiting bacterial growth (75%‐84% and 78–94% inhibition of P aeruginosa and S aureus, respectively, as compared to original polyvinylchloride) and killing bacteria. These results demonstrate that covalent polymer attachment conferred antifouling and antibacterial properties to the polyvinylchloride surface. [ABSTRACT FROM AUTHOR]