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The temporal relationship between global glaciations and the Great Oxidation Event (GOE) suggests that climate change played an important role in Earth's oxygenation. The potential role of temperature is captured by the stratigraphic proximity between glacial deposits and sediments containing mass‐independent fractionation of sulfur isotopes (MIF‐S). We use a time‐dependent one‐dimensional photochemical model to investigate whether temperature changes associated with global glaciations can drive oscillations in atmospheric O2 levels and MIF‐S production across the GOE. We find that extreme climate change can cause atmospheric O2 to oscillate between pre (<10−6 times the present atmospheric level, PAL) and post‐GOE (>10−5 PAL) levels. Post‐glacial hot‐moist greenhouse climates lead to post‐GOE O2 levels because the abundant H2O vapor and oxidizing radicals drive the depletion of reduced species. This pattern is generally consistent with the MIF‐S signal observed in the sedimentary record, suggesting a link between global glaciations and O2 oscillations across the GOE. Plain Language Summary: The Great Oxidation Event was the most significant environmental and chemical transformation in Earth's history, marking the first time oxygen accumulated in the atmosphere around 2.4 billion years ago. Oxygen increased from below one millionth (low) to at least one‐thousandth of a percent (intermediate) of the present oxygen concentration during this event. However, measurements of geochemical oxygen proxies suggest that oxygen levels oscillated between low and intermediate levels before stabilizing after this event. The first rise of atmospheric oxygen occurred during a period of extreme climate variability indicated by the presence of glacial rock deposits around this time. In this study, we use a time‐dependent photochemical model to show that extreme temperature changes caused by global glaciations can drive oscillations in atmospheric oxygen levels across the Great Oxidation Event (GOE). Our results can help explain why atmospheric oxygen shows drastic changes across the GOE in a way that is consistent with the geochemical record. Key Points: Across the Great Oxidation Event (GOE), extreme climate change linked to global glaciations can drive oscillations in atmospheric O2 levels and mass‐independent fractionation of sulfur isotopes (MIF‐S) productionGlacial climates and hot‐moist greenhouse climates were likely characterized by pre‐GOE and post‐GOE O2 levels respectivelyTemperature changes associated with global glaciations can help explain the MIF‐S record across the GOE [ABSTRACT FROM AUTHOR]

Demographic bottlenecks generally reduce genetic diversity through more intense genetic drift, but their net effect may vary along the genome due to the random nature of genetic drift and to local effects of recombination, mutation, and selection. Here, we analyzed the changes in genetic diversity following a bottleneck by comparing whole‐genome diversity patterns in populations with and without severe recent documented declines of Iberian (Lynx pardinus, n = 31) and Eurasian lynx (Lynx lynx, n = 29). As expected, overall genomic diversity correlated negatively with bottleneck intensity and/or duration. Correlations of genetic diversity with divergence, chromosome size, gene or functional site content, GC content, or recombination were observed in nonbottlenecked populations, but were weaker in bottlenecked populations. Also, functional features under intense purifying selection and the X chromosome showed an increase in the observed density of variants, even resulting in higher θW diversity than in nonbottlenecked populations. Increased diversity seems to be related to both a higher mutational input in those regions creating a large collection of low‐frequency variants, a few of which increase in frequency during the bottleneck to the point they become detectable with our limited sample, and the reduced efficacy of purifying selection, which affects not only protein structure and function but also the regulation of gene expression. The results of this study alert to the possible reduction of fitness and adaptive potential associated with the genomic erosion in regulatory elements. Further, the detection of a gain of diversity in ultra‐conserved elements can be used as a sensitive and easy‐to‐apply signature of genetic erosion in wild populations. [ABSTRACT FROM AUTHOR]

In order to address environmental aspects during redesign, the product specification must include related targets that are reachable and challenging. To do so, this article presents a stepwise approach for combining benchmarking information and component impact, out of life cycle assessment (LCA) scaling. This approach requires allocating environmental impacts to each subsystem, which is not commonly done for some life cycle phases in LCAs, most particularly for use phases. This article includes a methodology for allocating such impacts. The underlying criterion is avoiding complex calculations, to make the method more agile. This methodology is presented in a full case study of a complex product: a knuckle boom crane. The case study results in the percentage of impact reduction needed to meet the market average or best competitors. In particular, the results show that the cylinders of the crane have a high contribution to environmental impact, not only because of their weight, but also because of the active power consumed to activate them. [ABSTRACT FROM AUTHOR]

Many authors have agreed on the interest of considering environmental concerns in the early stages of product development. However, most eco-design tools are based on life cycle assessment principles and require a model to give information about the product's environmental performance. This modeling can have negative effects on team performance and on the potential for innovation, not to mention on the project's duration. Additionally, the model requires information that is not available in the early design stages. This article analyzes the potential of inferring conclusions about the life cycle stages with the highest impact by using similar products. From a database of previous products, environmental profile estimations are carried out, that is, the assessments of the contribution of each life cycle stage to the total impact and the variability of this measure. It is then possible to discard-or ensure consideration of-life cycle stages. Furthermore, the level of the conclusions is assessed on a five-point scale. The proposed approach is applied to four case studies with different levels of abstraction and the relevance of the conclusions is assessed. The article resolves the problems regarding potential for estimating the distribution of the environmental impacts along the life cycle. [ABSTRACT FROM AUTHOR]

Aim: Genome‐wide genetic data can provide key input for both taxonomy and conservation, but its use in this context remains limited. In this study, we performed the first genome‐wide assessment of genetic variation in two populations of the Eurasian lynx, the Balkan population, the most threatened, and the Caucasian population, a possible glacial refugium, with the aim to place them in the context of the species, investigate their demographic history and evaluate their genetic status. Location: The Balkans and the Caucasus. Methods: We obtained whole genome resequencing data from seven Balkan and 12 Caucasian lynx, and analysed them along with novel and existing data from other populations. Based on a total 105 whole genome and 114 mitogenome sequences, we reconstructed phylogenetic and historical relationships, ancient and recent demography, and patterns of genetic diversity and inbreeding. Results: Both the Balkan and the Caucasian lynx appear as distinct mitochondrial lineages that diverged from the rest of the Eurasian lynx lineages ca. 92.6 kya, and from each other ca. 46.4 kya. Autosomal data suggest, however, that the Balkan lynx is closely related with the Carpathian population, and revealing alarmingly low genetic diversity and high inbreeding. In contrast, the Caucasian lynx shows a longer history of relative isolation from the rest of lynx populations and high genetic diversity, consistent with its large long‐term effective population size. Main conclusions: The taxonomic status of the Balkan lynx remains unresolved due to the evidence of long‐term isolation in the mitogenome, contrasting with extensive autosomal admixture and intense recent genetic drift in the nuclear genome. Our results alert on genetic risks and call for the consideration of genetic rescue from closely related Carpathian lynxes. In contrast, substantial mitogenomic and autosomal divergence with no signs of genetic drift supports the identification of the Caucasian lynx as a separate subspecies with good genetic health. [ABSTRACT FROM AUTHOR]

Disentangling the contribution of long‐term evolutionary processes and recent anthropogenic impacts to current genetic patterns of wildlife species is key to assessing genetic risks and designing conservation strategies. Here, we used 80 whole nuclear genomes and 96 mitogenomes from populations of the Eurasian lynx covering a range of conservation statuses, climatic zones and subspecies across Eurasia to infer the demographic history, reconstruct genetic patterns, and discuss the influence of long‐term isolation and/or more recent human‐driven changes. Our results show that Eurasian lynx populations shared a common history until 100,000 years ago, when Asian and European populations started to diverge and both entered a period of continuous and widespread decline, with western populations, except Kirov, maintaining lower effective sizes than eastern populations. Population declines and increased isolation in more recent times probably drove the genetic differentiation between geographically and ecologically close westernmost European populations. By contrast, and despite the wide range of habitats covered, populations are quite homogeneous genetically across the Asian range, showing a pattern of isolation by distance and providing little genetic support for the several proposed subspecies. Mitogenomic and nuclear divergences and population declines starting during the Late Pleistocene can be mostly attributed to climatic fluctuations and early human influence, but the widespread and sustained decline since the Holocene is more probably the consequence of anthropogenic impacts which intensified in recent centuries, especially in western Europe. Genetic erosion in isolated European populations and lack of evidence for long‐term isolation argue for the restoration of lost population connectivity. [ABSTRACT FROM AUTHOR]

Ultra‐high performance fiber reinforced concrete (UHPFRC) is a unique class of fiber‐reinforced concrete featuring ultra‐high compressive strength and ductile tensile strain hardening behavior, accompanied by multiple narrow cracking. Although many studies have confirmed its superior mechanical and damage tolerance properties under monotonic or blast loading, limited research has been carried out on the cyclic performance of UHPFRC structural members. This paper proposes the use of UHPFRC to improve the cyclic performance of structural elements. An experimental program was carried out on a large number of UHPFRC beam‐column joint specimens under a cyclic lateral load. After the cyclic loading test, the following results were obtained: (a) hysterical performance, (b) maximum load, (c) maximum displacement, (d) the maximum energy dissipation (measured by hysteresis cycles), (e) stiffness degradation, (f) the cracking pattern, and (g) the cracking area. The analysis showed that UHPFRC specimens have at least 157% higher energy dissipation than nonfiber conventional reinforced concrete (RC). The initial stiffness of UHPFRC specimens without fibers (NF) was at least 23% higher than the RC specimen. For UHPFRC with fiber, initial stiffness was at least 45% higher than RC specimen. [ABSTRACT FROM AUTHOR]

The local geometry of the parameter space of a quantum system is described by the quantum metric tensor and the Berry curvature, which are two fundamental objects that play a crucial role in understanding geometrical aspects of condensed matter physics. Classical integrable systems are considered and a new approach is reported to obtain the classical analogs of the quantum metric tensor and the Berry curvature. An advantage of this approach is that it can be applied to a wide variety of classical systems corresponding to quantum systems with bosonic and fermionic degrees of freedom. The approach used arises from the semiclassical approximation of the Berry curvature and the quantum metric tensor in the Lagrangian formalism. This semiclassical approximation is exploited to establish, for the first time, the relation between the quantum metric tensor and its classical counterpart. The approach described is illustrated and validated by applying it to five systems: the generalized harmonic oscillator, the symmetric and linearly coupled harmonic oscillators, the singular Euclidean oscillator, and a spin‐half particle in a magnetic field. Finally, some potential applications of this approach and possible generalizations that can be of interest in the field of condensed matter physics are mentioned. [ABSTRACT FROM AUTHOR]

SUMMARY In this paper, a digital filter for the generation/correlation of binary Golay pairs of sequences of length 2 N · 10 M · 26 P ( N, M and P are non-negative integers) is proposed. It is carried out by means of a novel Golay kernel 26 decomposition, also introduced in this paper, combined with building blocks of Golay kernels 2 and 10, presented in previous works. The proposed filter has a similar architecture to the digital filter for the generation/correlation of Golay multilevel pairs of sequences, where the parameters at intermediate stages have to be adjusted to obtain Golay binary pairs of sequences in the final stage. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Thrombin-activatable fibrinolysis inhibitor (TAFI) plays a role in the regulation of coagulation and inflammation. In addition to inhibiting the fibrinolytic system, TAFI may also regulate the bradykinin and complement systems. We hypothesized that TAFI also plays a role in defense mechanisms of the gastric mucosa during Helicobacter pylori infection. This study comprised 65 patients with gastroduodenal disorders: 41 patients with H. pylori infection, 13 without, and 11 patients with cured H. pylori infection. The gastric intramucosal concentrations of TAFI were measured by enzyme immunoassay. The gastric levels of TAFI and plasminogen activator inhibitor-1 were significantly increased in patients with H. pylori compared to those without infection or cured H. pylori. The presence of TAFI was detected in gastric mucosal epithelial cells. The concentration of TAFI was correlated with the degree of gastric mucosal atrophy, inflammation, and disease activity. These results show that TAFI is present in the gastric mucosa and that it may play a role in the pathogenesis of H. pylori infection-associated gastroduodenal disorders. [ABSTRACT FROM AUTHOR]