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This article highlights the 5th International Criminological Congress of the International Society for Criminology to be held in Montreal, Quebec, from August 29 to September 3, 1965.

The volume at hand presents the special issue of the 12th International Conference on Software and Systems Process (ICSSP) 2019, which was held in Montreal, Canada, from May 25 to 26, 2019. ICSSP 2019 is the latest in a series of conferences that have been organized by the International Software and Systems Process Association. In our evolving landscape, many companies are making efforts to move towards new technologies and tools, agile principles, and continuous integration and delivery. In doing so, they find opportunity, flexibility, and strength in evolving towards hybrid processes, which are neither purely traditional nor can count as textbook agile. This special issue focuses on hybrid processes. [ABSTRACT FROM AUTHOR]

The assessment of infrastructure conditions is at present a topic of great interest and importance, as well as great challenge. This paper presents a case study of the Samuel De Champlain Bridge (Montreal, QB, Canada), an outstanding stay cable bridge equipped with a comprehensive monitoring system (SHM). Among other SHM features, particular attention was paid to implementation of a strategic corrosion monitoring system. This paper intends to describe the concept design, implementation and data interpretation. Here corrosion sensors have been embedded during construction stage to monitor long term evolution of key electro‐chemical parameters for controlling deterioration of materials. Furthermore, these sensors measure stray current interference generated from the rail system that can cause corrosion. In both cases, abnormal values would warn the owner of the associated increased risk of corrosion. This gives them the possibility to take corrective measures to protect the structure before corrosion becomes a serious threat. [ABSTRACT FROM AUTHOR]

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This paper is offered as a complementary adjunct to the many treatments of the electronic and photonic properties of cubic III–V and II–VI compounds appearing in the literature. These crystals typically exhibit piezoelectricity, due to the molecular dissymmetry, thereby allowing the inclusion of classical mechanical/acoustic features along with the quantum. We discuss the history of this modality and then illustrate its use by applying it to an electro‐elastic problem that has the estimable virtues of having an exact solution, along with wide practical applicability: determination of the piezocoupling values governing the excitation of thickness vibrations in thin cubic films or plates of arbitrary crystallographic orientation by electric fields directed either along, or lateral to, the thickness. Explicit results are given for orientations along the great‐circle paths connecting the principal directions [100], [110], and [111]. The formalism is then applied to GaAs as an example; it is further demonstrated that various results, such as the orientational variations of piezocoupling factors, are generally applicable to other members of the III–V and II–VI families by scaling. Ancillary aspects, such as errors due to misorientations, nonlinearities, and equivalent circuit representations, are described and discussed. This work is dedicated to Gerald W. Farnell (1925–2015), Prof. Emeritus, McGill University, Montréal, Canada. [ABSTRACT FROM AUTHOR]

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Highlights the Early Experiential Deprivation and Enrichment and Later Development symposium in Montreal, Quebec. Proponents of developmentalism in psychology; Styles of verbal interaction between mother and child; Identification of basic sensory and perceptual mechanisms.

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Fecal microbiota transplantation (FMT), which is thought to have the potential to correct dysbiosis of gut microbiota, has been used to treat inflammatory bowel disease (IBD) for almost a decade. Here, we report an interventional prospective cohort study performed to elucidate the extent of and processes underlying microbiota engraftment in IBD patients after FMT treatment. The cohort included two categories of patients: (a) patients with moderate to severe Crohn's disease (CD) (Harvey–Bradshaw Index ≥ 7, n = 11) and (b) patients with ulcerative colitis (UC) (Montreal classification S2 and S3, n = 4). All patients were treated with a single FMT (via mid‐gut, from healthy donors), and follow‐up visits were performed at baseline, 3 days, 1 week, and 1 month after FMT (missing time points included). At each follow‐up time point, fecal samples and clinical metadata were collected. For comparative analysis, 10 fecal samples from 10 healthy donors were included to represent the diversity level of normal gut microbiota. Additionally, the metagenomic data of 25 fecal samples from five individuals with metabolic syndrome who underwent autologous FMT treatment were downloaded from a previous published paper to represent fluctuations in microbiota induced during FMT. All fecal samples underwent shotgun metagenomic sequencing. We found that 3 days after FMT, 11 out of 15 recipients were in remission (three out of four UC recipients; 8 out of 11 CD recipients). Generally, bacterial colonization was observed to be lower in CD recipients than in UC recipients at both species and strain levels. Furthermore, across species, different strains displayed disease‐specific displacement advantages under two‐disease status. Finally, most post‐FMT species (> 80%) could be properly predicted (area under the curve > 85%) using a random forest classification model, with the gut microbiota composition and clinical parameters of pre‐FMT recipients acting as factors that contribute to prediction accuracy. [ABSTRACT FROM AUTHOR]

The article presents the minutes of the 40th Annual General Meeting of the Canadian Economics Association held at Montreal, Quebec, Canada in May 2006. They include approval of the agenda and presentation of reports by the president Gregor Smith, secretary-treasurer Frances Woolley, and Dwayne Benjamin, managing editor of the association's official journal.

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Copyright of Canadian Geographer is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: This paper aims to advance our understanding of the experience of participating in peer support groups for family members of persons with psychosis and to expand the scant body of literature on peer support in the context of early intervention services for psychosis. Such an examination is relevant because the implementation and uptake of family‐focused interventions remain inconsistent in early intervention services, despite their proven benefits. Methods: To enable family caregivers to support one another, a family peer support project was initiated at an early intervention service for psychosis in Montreal, Canada. A family peer support provider and researchers collaboratively designed and conducted this study to examine the experience of those who participated in family peer support groups. Forty‐four family members completed an English or French online questionnaire. Thematic analysis was used to code responses to open‐ended questions to unpack crucial elements of this peer support intervention. Results: Three key themes were identified—the impact of psychosis on families; understanding and coping with psychosis through family peer support; and improving family peer support services. Mutual support through sharing experiences; gains in knowledge of the illness and its treatment; emotional support; and increased caregiving and self‐care capacities and skills were identified as critical benefits of family peer support. Conclusion: Family peer support can be an acceptable and cherished means of engaging and sustaining families and enhancing their caregiving skills. Its integration into early intervention services holds the promise of helping promote recovery and reducing caregiver burden. [ABSTRACT FROM AUTHOR]

Past major earthquakes have demonstrated that a significant proportion of existing residential buildings are vulnerable to seismic hazards, resulting in economic and social losses. The assessment of earthquake‐induced losses is crucial for devising strategies aimed at enhancing seismic resilience through mitigation plans and emergency response measures. This study intends to provide an analytical methodology for evaluating economic losses for existing residential concrete shear wall buildings in Eastern Canada seismic zones based on Canadian‐compatible seismic capacity parameters. A sampled data set related to residential buildings in Montreal was analyzed and statistical distributions were developed that represent the proportion of buildings in different seismic design code levels and number of stories. Vulnerability analyses were performed, which involved estimating buildings' response under seismic hazard inputs according to the 2020 National Building Code of Canada and conducting loss assessment for structural components, nonstructural displacement‐sensitive components, nonstructural acceleration‐sensitive components, and contents. The results of vulnerability analyses in terms of loss ratio curves showed that the seismic performance varies between mid‐rise and high‐rise concrete shear wall buildings with different seismic design code levels, and nonstructural displacement‐sensitive components exerted the most significant influence on overall economic losses among building components. In addition, a comparison was conducted between Canadian‐compatible economic loss ratio curves and those developed based on the standard seismic capacity parameters in the Hazus technical manual and differences in predicted loss ratios were discussed. The developed loss ratio curves can be integrated into regional scale loss assessment tools for rapid estimation of earthquake‐induced economic losses for concrete shear wall buildings as a function of seismic intensity. [ABSTRACT FROM AUTHOR]

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Constitutional entanglements in Canada–Quebec relations are well known. From one referendum on Quebec’s sovereignty to the other, from one pan–Canadian constitutional meeting to the other, the ‘Quebec problem’ seems irresolvable. One dimension is constantly overlooked in this debate: territorial identity. Territorially–based cultural claims emerge in the core of urban Quebec under the leadership of partitionist and localist movements. Originally based in Montreal, the partitionist movement is driven by Anglo–Que´be´cois claims over local municipalities and certain parcels of the territory in the event of an independent Quebec. This paper seeks to understand a dual reterritorialisation process: 1) state territorial rescaling policies such as decentralisation and metropolitan reform, and 2) the use of territorial claims underpinning social mobilisation strategies. When state territorial restructuring policies do not correspond with the local territorial political culture, as I argue in the case of a ‘frontier–city’ like Montreal, it spurs the activation of strategic territorialisation. This paper begins with an analysis of Montreal’s territorial political culture, rooted in the coexistence of opposite territorial myths and a common feeling of distinctiveness. Then follows a discussion of strategic territorialisation and the poly–scalar nature of such mobilisation. [ABSTRACT FROM AUTHOR]

The International Social Security Association is marking this year its 60th Anniversary, and this is an appropriate time to consider and evaluate the organization's work. Does the apparatus of Committees, reports and a triennial Assembly justify the cost of participation by members, ultimately borne by contributors or taxpayers? The paper gives a brief history of ISSA and its forerunners, describes the working methods, gives an account of the 22nd Assembly held in 1986 in Montreal, and concludes with an assessment of its efficacy. [ABSTRACT FROM AUTHOR]

The literature on routinization of work is both ambiguous and equivocal when its impact on quality of working life is considered. The classical management literature suggests that routinization of work has a positive influence on individual performance and by implication on the quality of working life resulting from the overall prosperity generated. However, more recent literature on job characteristics and job design argues that routinization of work has a negative impact on individual performance as it suppresses creative expression on the job. This paper suggests that these mixed findings are due to an inadequate theoretical grasp of the concept of routinization and presents empirical evidence which attempts to clarify the ambiguity. Data were collected from 1148 nurses working in anglophone hospitals in the greater Montreal area in the form of a field survey questionnaire. The results indicated that nurses who worked routine shifts perceived higher levels of quality of working life compared to those on non-routine shifts. The results also indicated that nurses who experienced high routinization in job content perceived lower levels of quality of working life compared to those nurses who experienced low routinization in job content. Implications of these findings for future research are discussed. The literature on routinization of work is both ambiguous and equivocal when its impact on quality of working life is considered. The classical management literature suggests that routinization of work has a positive influence on individual performance and by implication on the quality of working life resulting from the overall prosperity generated. However, more recent literature on job characteristics and job design argues that routinization of work has a negative impact on individual performance as it suppresses creative expression on the job. This paper suggests that these mixed findings are due to an inadequate theoretical grasp of the concept of routinization and presents empirical evidence which attempts to clarify the ambiguity. Data were collected from 1148 nurses working in anglophone hospitals in the greater Montreal area in the form of a field survey questionnaire. The results indicated that nurses who worked routine shifts perceived higher levels of quality of working life compared to those on non-routine shifts. The results also indicated that nurses who experienced high routinization in job content perceived lower levels of quality of working life compared to those nurses who experienced low routinization in job content. Implications of these findings for future research are discussed. [ABSTRACT FROM AUTHOR]

A few highly publicized food supply chain disruptions early in the COVID‐19 pandemic were interpreted by some as evidence of a "broken" food system. One solution often brought in response to that perceived brokenness is urban agriculture. The literature, however, has sidestepped a key question: Who practices urban agriculture? Using survey data on 882 Montreal residents, we find that those who practice urban agriculture are more educated, and more likely to be homeowners and to report an income in the highest income bracket. This is consistent with urban agriculture being a luxury good. [ABSTRACT FROM AUTHOR]

Implementation and funding mechanisms to reverse biodiversity loss formed the core of the discussion focusing on the Post‐2020 Global Biodiversity Framework ("the Framework"), at the 15th Conference of Parties at the Convention on Biological Diversity hosted by China. Before financial support emerged from the private sector in China, biodiversity conservation had primarily been financed by the government. By the end of the 20th‐century international nongovernmental organizations and China's local philanthropists began to launch pilot programs in the country. In the past 5 years, biodiversity conservation across China has received CNY 1.757 billion (approximately $279 million) from the philanthropy sector. It represents the largest‐ and fastest‐growing share (69%) of environmental philanthropic funding; however, it accounted for <1% of all the philanthropic in all sectors nationwide. We suggested Foundations and NGOs review and adjust their strategies to align with the Kunming‐Montreal global biodiversity framework. Proactive connection and engagement with the philanthropies is required to expand its contributions while providing better pathways and support mechanisms for philanthropic funding for biodiversity conservation. Despite the philanthropic funding provided has been relatively modest over the past few decades, the philanthropic organizations have achieved significant positive results for biodiversity conservation in China. However, the funding for biodiversity conservation falls far short of what is needed to achieve the goals under the Kunming‐Montreal global biodiversity framework. This study provides a comprehensive overview of biodiversity philanthropic funding in China. Based on the collection of data related to environmentally relevant grants provided by companies, foundations, and individuals, we conducted a visualization analysis to reveal China's philanthropic funding flows between 2016 and 2020 in China. The profiles of donors and the receipts of the funding have been described. [ABSTRACT FROM AUTHOR]

Symbolic healing, that is, responding to meaningful experiences in positive ways, can facilitate human healing. This process partly engages consciousness and partly evades consciousness completely (sometimes it partakes of both simultaneously). This paper, presented as the Society for the Anthropology of Consciousness Distinguished Lecture at the 2011 AAA meeting in Montreal, reviews recent research on what is ordinarily (and unfortunately) called the 'placebo effect.' The author makes the argument that language use should change, and the relevant portions of what is often called the placebo effect should be referred to as the 'meaning response.' [ABSTRACT FROM AUTHOR]

Copyright of Journal of Analytical Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Context The McGill University Faculty of Medicine undertook a pilot, simulation-based multiple mini-interview (MMI) for medical school applicant selection, which ran simultaneously with traditional unstructured interviews (all applicants underwent both processes). This paper examines major stakeholder (applicants and evaluators) opinions towards the MMI compared with traditional interviews, including perceptions about the feasibility and utility of the MMI. Methods A total of 100 candidates applying to McGill University Medical School were enrolled in the pilot comparison of the MMI with the traditional, unstructured interview. Applicants’ opinions were obtained by questionnaire shortly after the process (for all applicants) and approximately 6 months after the interviews (for non-accepted applicants). Evaluators’ perceptions were also surveyed. Questionnaires contained both quantitative items and space for qualitative impressions. Descriptive statistics, repeated measures analysis of variance (manova) and analysis of the topics raised in written comments were conducted. Results Univariate analyses of response scores revealed statistically significant differences, with the MMI rated more highly than the traditional interview on fairness, imposition of stress and effectiveness as a measurement tool. Compared with the traditional interview, applicants also felt the MMI: (i) allowed them to be competitive; (ii) was enjoyable, and (iii) was often a favourite part of their interview experience. It should be noted that applicants were aware that their MMI score would be included in their overall interview rating. Written comments were positive with regard to, for example, fairness, the provision of opportunities to show one’s strengths, and appreciation of the fidelity of the simulations. Evaluators’ responses were in agreement with applicants’ responses, albeit that overall they expressed more caution about the MMI. Conclusions Results suggest the MMI is a promising selection tool from the point of view of both applicants and evaluators. Both groups expressed concerns, but overall the response was favourable for the MMI in comparison with traditional interviews, and the MMI has been adopted by McGill University’s medical school. [ABSTRACT FROM AUTHOR]

The growing diaspora in migration has prompted Western countries in recent years to examine the factors contributing to the economic integration of newcomers. If their integration is unsuccessful, it could create economic inequalities and be burdensome to the host society. The inequalities experienced by working immigrants have often been examined through cross-sectional data describing the situation at a specific moment in time, with limited consideration of the complexity of the immigrant's settlement experience. This paper examines the economic integration of new immigrants through prospective analysis and considers multiple factors concurrently in an effort to address some of this complexity. The current study focuses on employment disparities across source regions. The analyses are taken from a ten-year longitudinal survey describing the socio-economic experience of 429 new immigrants settled in the Montreal metropolitan area. Over time, wage and occupational mobility increase, although it appears stagnant for different groups of respondents from specific regions such as East Asia, North Africa and the Middle East. Also, like respondents from sub-Saharan Africa, these respondents face difficulties sustaining a position in the labour market. [ABSTRACT FROM AUTHOR]

The article presents an introduction to a series of articles on "Disorders and Plasticity," which was the theme of the Neuroscience and Music (Neuromusic) conference in Montreal, Quebec. One of the papers is related to music neuroscience research which has now arrived. Another paper is concerning the gap between applied and basic research which can be filled by collaborations.

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Copyright of Canadian Geographer is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The article presents information about Focus Group Discussion International Congress on Licensure, Certification and Credentialing of Psychologists, Montreal, Quebec. It focuses on the feasibility of a universal declaration of ethical principles for psychologists. In July 2002, Janel Gauthier presented a paper at a symposium on professional codes of ethics across national boundaries at the International Congress of Applied Psychology in Singapore. During the Congress in Montreal, Janel made a presentation during which he described a proposed framework for the development of a universal declaration of ethical principles for psychologists. It discusses the declarations of ethical principles for psychologists feasible on a world-wide basis. Janel has identified five principles that appear to be common in codes of ethics across four continents. To achieve a high level of consensus, it will be essential to take into account the huge diversity in the world and differences in worldview. It was suggested that the preamble indicate that these principles could be interpreted in different ways in different cultures.

The article discusses on the travel distance approximation in geographic information system (GIS)-based decision support system (DSS) in Montreal, Quebec. An interactive tool for strategic and tactical decision making, DDS was developed to approximate distances traveled by large trucks hauling snow in an urban snow disposal decision support system. Winter maintenance operations are necessary to maintain safe travel conditions in urban regions that experience heavy snowfall. In Montreal, the average annual winter maintenance budget would amount up to more than sixty million dollars.

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Introduction: Long-acting injectable cabotegravir (CAB-LA) demonstrated superiority to daily tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) for HIV pre-exposure prophylaxis (PrEP) in the HPTN 083/084 trials. We compared the potential impact of expanding PrEP coverage by offering CAB-LA to men who have sex with men (MSM) in Atlanta (US), Montreal (Canada) and the Netherlands, settings with different HIV epidemics. Methods: Three risk-stratified HIV transmission models were independently parameterized and calibrated to local data. In Atlanta, Montreal and the Netherlands, the models, respectively, estimated mean TDF/FTC coverage starting at 29%, 7% and 4% in 2022, and projected HIV incidence per 100 person-years (PY), respectively, decreasing from 2.06 to 1.62, 0.08 to 0.03 and 0.07 to 0.001 by 2042. Expansion of PrEP coverage was simulated by recruiting new CAB-LA users and by switching different proportions of TDF/FTC users to CAB-LA. Population effectiveness and efficiency of PrEP expansions were evaluated over 20 years in comparison to baseline scenarios with TDF/FTC only. Results: Increasing PrEP coverage by 11 percentage points (pp) from 29% to 40% by 2032 was expected to avert a median 36% of new HIV acquisitions in Atlanta. Substantially larger increases (by 33 or 26 pp) in PrEP coverage (to 40% or 30%) were needed to achieve comparable reductions in Montreal and the Netherlands, respectively. A median 17 additional PYs on PrEP were needed to prevent one acquisition in Atlanta with 40% PrEP coverage, compared to 1000+ in Montreal and 4000+ in the Netherlands. Reaching 50% PrEP coverage by 2032 by recruiting CAB-LA users among PrEP-eligible MSM could avert >45% of new HIV acquisitions in all settings. Achieving targeted coverage 5 years earlier increased the impact by 5-10 pp. In the Atlanta model, PrEP expansions achieving 40% and 50% coverage reduced differences in PrEP access between PrEP-indicated White and Black MSM from 23 to 9 pp and 4 pp, respectively. Conclusions: Achieving high PrEP coverage by offering CAB-LA can impact the HIV epidemic substantially if rolled out without delays. These PrEP expansions may be efficient in settings with high HIV incidence (like Atlanta) but not in settings with low HIV incidence (like Montreal and the Netherlands). [ABSTRACT FROM AUTHOR]

Aim: Despite their emphasis on engagement, there has been little research on patients' and families' experiences of care in early intervention services for psychosis. We sought to compare patients' and families' experiences of care in two similar early psychosis services in Montreal, Canada and Chennai, India. Because no patient‐ or family‐reported experience measures had been used in a low‐ and middle‐income context, we created a new measure, Show me you care. Here we present its development and psychometric properties. Methods: Show me you care was created based on the literature and stakeholder inputs. Its patient and family versions contain the same nine items (rated on a 7‐point scale) about various supportive behaviours of treatment providers towards patients and families. Patients (N = 293) and families (N = 237) completed the measure in French/English in Montreal and Tamil/English in Chennai. Test–retest reliability, internal consistency, convergent validity, and ease of use were evaluated. Results: Test–retest reliability (intra‐class correlation coefficients) ranged from excellent (0.95) to good (0.66) across the patient and family versions, in Montreal and Chennai, and in English, French, and Tamil. Internal consistency estimates (Cronbach's alphas) were excellent (≥0.87). The measure was reported to be easy to understand and complete. Conclusion: Show me you care fills a gap between principles and practice by making engagement and collaboration as central to measurement in early intervention as it is to its philosophy. Having been co‐designed and developed in three languages and tested in a low‐and‐middle‐income and a high‐income context, our tool has the potential for global application. [ABSTRACT FROM AUTHOR]

Introduction: People with opioid use disorders (OUD) present with high levels of medical and psychosocial vulnerabilities. In recent years, studies have highlighted a shift in demographic and biopsychosocial profiles of people with OUD. In order to support the development of a profile‐based approach to care, this study aims to identify different profiles of people with OUD in a sample of patients admitted to a specialised opioid agonist treatment (OAT) facility. Methods: Twenty‐three categorical variables (demographic, clinical, indicators of health and social precariousness) were retrieved from a sample of 296 patient charts in a large Montréal‐based OAT facility (2017–2019). Descriptive analyses were followed by a three‐step latent class analysis (LCA) to identify different socio‐clinical profiles and examine their association with demographic variables. Results: The LCA revealed three socio‐clinical profiles: (i) "polysubstance use with psychiatric, physical and social vulnerabilities" (37% of the sample); (ii) "heroin use with vulnerabilities to anxiety and depression" (33%); (iii) "pharmaceutical‐type opioid use with vulnerabilities to anxiety, depression and chronic pain" (30%). Class 3 individuals were more likely to be aged 45 years and older. Discussion and Conclusion: While current approaches (such as low‐ and regular‐threshold services) may be suited for many OUD treatment entrants, there may be a need to improve the continuum of care between mental health, chronic pain, and addiction services for those characterised by the use of pharmaceutical‐type opioids, chronic pain and older age. Overall, the results support further exploring profile‐based approaches to care, tailored to subgroups of patients with differing needs or abilities. [ABSTRACT FROM AUTHOR]

For too long and with ever‐increasing ferocity during the past decades of an exponentially growing human world population, humankind has been waging a genuine war against nature, of which we ourselves are nevertheless also a part. We are plundering the unique biological treasure, the diversity of species, without which the ecosystems we rely on for our food, our water and so much more would not function. At present, we are already in the midst of a massive decline of populations and species, with a significantly higher extinction rate than the long‐term average. Driven essentially by habitat loss and degradation, direct exploitation through legal and illegal hunting and fishing as well as pesticides and pollution, within decades, 1 million species out of a total of 8 million could go extinct. Alongside climate change, this dramatic decay of biodiversity, that involves also the subsequent loss of ecosystem services, here termed 'the end of evolution', is another and by no means lesser threat to humanity. We can still take countermeasures, but we must transform our economy and change our way of living. As most successful strategy the protection of up to 30% of Earth's surface by 2030 was suggested, ideally based on the implementation of a consistent framework of global ecosystems, as it was agreed on by the December 2022 United Nations Conference of Parties (COP15) Montreal meeting for the Conservation on Biological Diversity. [ABSTRACT FROM AUTHOR]

Background: Direct‐acting antiviral agents (DAAs) have transformed chronic hepatitis C (CHC) treatment. Continued affordable access to DAAs requires updated cost‐effectiveness analyses (CEA). Utility is a preference‐based measure of health‐related quality of life (HRQoL) used in CEA. This study evaluated the impact of DAAs on utilities for patients with CHC in two clinical settings. Methods: This prospective longitudinal study included patients aged ≥18 years, diagnosed with CHC and scheduled to begin DAA treatment, from two tertiary care hospital clinics and four community clinics in Toronto, Calgary, and Montreal. Patients completed two utility instruments (EQ‐5D‐5L and Health Utilities Index 2/3 (HUI2/3)) before treatment, 6 weeks after treatment initiation, and 12 weeks and 1 year after treatment completion. We measured utilities for all patients, and for hospital‐based and community‐based groups. Results: Between 2017 and 2020, 209 patients (126 hospital‐based, 83 community‐based; average age 53 years; 65% male) were recruited, and 143 completed the 1‐year post‐treatment assessment. Pre‐treatment, utilities were (mean ± standard deviation) 0.77 ± 0.21 (EQ‐5D‐5L), 0.69 ± 0.24 (HUI2) and 0.58 ± 0.34 (HUI3). The mean changes at 1‐year post‐treatment were 0.035, 0.038 and 0.071, respectively. While utilities for hospital‐based patients steadily improved, utilities for the community‐based cohort improved between baseline and 12‐weeks post‐treatment, but decreased thereafter. Discussion: This study suggests that utilities improve after DAA treatment in patients with CHC in a variety of settings. However, community‐based patients may face challenges related to comorbid health and social conditions that are not meaningfully addressed by treatment. Our study is essential for valuing health outcomes in CHC‐related CEA. [ABSTRACT FROM AUTHOR]

Background: The effectiveness of early prevention programmes and their viability as a public policy option have increasingly caught the attention of scholars and policymakers. Given the implementation costs of such programmes, it is important to assess whether they achieved anticipated objectives and whether they made efficient use of taxpayer money. Aim: To discuss the social and economic impact of a 2‐year randomised intervention aimed to improve social skills and self‐control (i.e., non‐cognitive skills) among disruptive boys from low‐income neighbourhoods in Montreal. Method: We review findings from published studies documenting the impact of the intervention at different stages of the life course, as well as its cost‐effectiveness and cost‐benefit. Results: The intervention improved behavioural indicators throughout adolescence and eventually led to greater high school graduation rates, reduced crime, and better labour market outcomes in adulthood. Importantly, the prevention programme generated considerable returns to taxpayer investments. Conclusion: Findings from the Montreal Longitudinal Experimental Study have been well‐received and have contributed to an early prevention 'awakening' in Quebec and elsewhere. [ABSTRACT FROM AUTHOR]

Achieving net zero carbon dioxide (CO2) emissions will require the cessation of fossil fuel emissions into the atmosphere, yet the need for 'fuel' and energy storage will remain. One solution could be a carbon‐based fuel system where CO2 of biogenic origin is converted to fuels using hydrogen generated by electrolysis powered by renewable energy sources. Methane has value as an initial target given its prevalence in biogas, use in home heating and in electricity generation. Sources of CO2 in Eastern Canada are dominated by the iron and steel, cement, and aluminium industries, all of which have biogenic fuel options. Collecting all of the potentially biogenic CO2 would displace 75% of current natural gas use and require a 50% increase in generating capacity. Initial efforts could site a carbon capture, utilization, and storage facility near Montreal, QC, with other large‐scale facilities near Hamilton, ON, and Lac St‐Jean, QC. These facilities would be grid connected and expected to operate ~6200 h annually. The most high‐frequency electrolysis events would be 10 h of run time and 2 h of idle time. These periods would peak during the equinox months and be at a minimum during the winter solstice. These operational assumptions will all be subject to the increased variability caused by anthropogenic climate change and increased renewable generation on the grid. A closed‐loop carbon‐based fuel system would require an equivalent price of $250 per tonne CO2. [ABSTRACT FROM AUTHOR]

Information about several papers discussed at a symposium organized by Jean Gotman and François Dubeau, on epilepsy is presented. Topics include the malformations of cortical development, investigational and surgical aspects of the epilepsies and genetics of idiopathic epilepsies. The symposium took place at the Montreal Neurological Hospital and Institute in Montreal, Quebec.

Highlights the First International Conference on New Information Technologies for Decision Making in Civil Engineering held in Montreal, Quebec on October 11-13, 1998. Purpose of the conference; Topics of discussion; Number of research papers received.

Lesage: Montreal hosts four major universities (Figure 2), of which McGill University and I Université de Montréal i have graduate and postgraduate programs in immunology. Immunologists in Montreal are especially sought after for their renowned expertise in neuroimmunology, host-pathogen interactions, immunovirology, immunogenetics, transplantation and cancer immunology. The Université Laval, based in Québec city, also has an affiliated research center called I Centre Armand-Frappier Santé Biotechnologie i , just North of Montreal, with graduate and postgraduate programs in immunology. [Extracted from the article]

For both financial and environmental applications, tail distributions often correspond to extreme risks and an accurate modeling is mandatory. The peaks‐over‐threshold model is a classic way to model the exceedances over a high threshold with the generalized Pareto distribution. However, for some applications, the choice of a high threshold is challenging and the asymptotic conditions for using this model are not always satisfied. The class of extended generalized Pareto models can be used in this case. However, the existing extended model have either infinite or null density at the threshold, which is not consistent with tail modeling. In the present article, we propose new extensions of the generalized Pareto distribution for which the density at the threshold is positive and finite. The proposed extensions provide better estimate of the upper tail index for low thresholds than existing models. They are also appropriate for high thresholds because in that case, the extended models simplify to the generalize Pareto model. The performance and flexibility of the models are illustrated with the modeling of temperature exceeding a low threshold and non‐zero precipitations recorded in Montreal. For non‐zero precipitation, the very low threshold of 0 is used. [ABSTRACT FROM AUTHOR]

The retinoid (10mM) increased viral reactivation mediated by IL-15 to a similar extent as HODHBt (100mM) but unlike HODHBt, specifically promoted cell death of latently infected cells compared to controls when combined with IL-15. This indicates that the retinoid is able to reactivate latent HIV through a mechanism mediated by IL-15 but not directly dependent on STAT5 phosphorylation. Among the clinically relevant latency reversing agents (LRA) under investigation, IL-15 or the IL-15 superagonist N-803 have been shown to reactivate latent HIV I ex vivo i and I in vivo i . [Extracted from the article]

This article is a preliminary study into the impact of feminism within the Jewish‐Canadian community in Montreal in the 1960s and 1970s, based on a combination of archival research and oral history. This research reveals that while community, religious elites and ordinary Jewish women in Montreal did engage with feminist ideas right from the beginning, this engagement was limited in the 1960s and 1970s. Specifically, questions arose about the compatibility of feminism with Jewish religion and culture, particularly with respect to the devaluation of motherhood and family within the larger movement. As a result, Jewish women in Montreal selectively incorporated second‐wave feminism into their lives in contradictory and inconsistent ways, viewing the role of women in the home and family as a source of pride and strength. This suggests the need to rethink our image of feminism in this period by including new understandings of feminist activism and the possibility that the lack of connection over the subject of motherhood was the norm rather than the exception. [ABSTRACT FROM AUTHOR]

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The practical application of accurate design and coordination in Building Information Modeling (BIM) environment for precast rings in Tunnel Boring Machine (TBM)‐bored tunnels is becoming more achievable. These rings, made up of individual segments, are subject to many constraints which include: 1) deviations from theoretical alignment, as modeling the straight centerline of a ring into a curved alignment naturally produces minor deviations in line and grade, 2) avoiding crucifix joints when the joints between segments align in the longitudinal direction, reducing sealing performance, 3) and TBM shield design by minimizing the diameter of the TBM to reduce overcut and required backfill. This article describes the automated procedures for developing our design intent in the BIM environment with consideration for ring length optimization in tunnel curves, geometrical analyses of the staggered pattern of joints, and the minimum diameter and overcut envelope of the TBM shield. This procedure is demonstrated in multiple light‐rail transit lines in Montréal including the Réseau Express Métropolitain (REM) airport link tunnel and the expansion of the Montreal Blue Line Metro. Virtual build of these segmentally lined tunnels negotiating all straight and curved drives of the alignment with BIM modeling is realized and summarized in this article. [ABSTRACT FROM AUTHOR]

The article presents a case study which explores the function of public policy in gentrification in Montréal, Québec. The case addresses several questions such as one on the enactment of urban revitalisation through housing policy tools and one on the effect of economic development. It says that the case underscores the need to look at several factors which affect the status of local housing markets.

Aim: Most patients with ulcerative colitis (UC) with active mucosal disease have a lower C-reactive protein (CRP) level than the classic accepted cutoff level (≤5 mg/l). We aimed to predict the mucosal remission in UC with an optimal cutoff level of CRP when mucosal activity and extensiveness of UC were both considered. Method: In this retrospective study, we evaluated CRP values and their relation to mucosal extension and UC activity in 331 colonoscopic examinations performed between December 2016 and March 2019. Endoscopic activity and disease extension were assessed using Mayo scores and the Montreal classification. Results: The Mayo 2 and 3 groups’ CRP values were significantly higher when compared with Mayo 0–1 between values of E1 and both E2 and E3 with an increasing trend. The standard CRP cutoff level ≤5 mg/l only yielded 55% specificity in predicting mucosal remission. In the ROC analysis, a CRP cutoff level ≤2.9 mg/l predicted an overall mucosal remission (Mayo 0–1) with 77% sensitivity and 80% specificity, and ≤1.9 mg/l predicted Mayo-0 with 70% sensitivity and specificity. In the clinical remission subgroup, the overall CRP cutoff level was even lower, at ≤1.58 mg/l. Conclusion: An overall CRP cutoff level ≤2.9 mg/l predicts mucosal remission in UC better than the standard cutoff ≤5 mg/l. Mucosal remission in stable clinical remission may present with an even lower CRP level. An increasing trend in the CRP level from E1 through E3 even in mucosal remission suggests that both histological inflammation and extensiveness may have some influence on a CRP-based prediction of endoscopic remission [ABSTRACT FROM AUTHOR]

Objective: Body mass index (BMI) is used to identify trajectories of adiposity in youth, but it does not distinguish fat‐ from fat‐free‐mass. There are other inexpensive measures of adiposity which might better capture fat‐mass in youth The objective of this study is to examine differences between sex‐specific trajectories of BMI and other adiposity indicators (subscapular and triceps skinfold thickness, waist circumference, waist‐to‐height ratio) which may better capture fat‐mass in youth. Methods: Data come from four cycles of a longitudinal cohort of 1293 students in Montréal, Canada at ages 12, 15, 17 and 24. Group‐based trajectory models identified sex‐specific adiposity trajectories among participants with data in ≥3 cycles (n = 417 males; n = 445 females). Results: There were six trajectory groups in males and females for all five indicators, except for waist circumference (seven) in both sexes and triceps skinfold thickness (four) and waist‐to‐height ratio (five) in females. Most trajectories indicated linear increases; only the skinfold thickness indicators identified a decreasing trajectory. While all indicators identified a trajectory with high levels of adiposity, they differed in the number and relative size of trajectories pertaining to individuals in lower half of the adiposity distribution. Conclusion: BMI is a satisfactory indicator of adiposity in youth if the aim of the trajectory analysis is to identify youth with excess adiposity, a known risk factor for cardiometabolic outcomes in adulthood. [ABSTRACT FROM AUTHOR]

Background and objectives: Several approaches are currently under study to contribute to efforts to allow men who have sex with men (MSM) to donate blood. One of these approaches involves implementing a programme of plasma donation for fractionation, with a quarantine period. The goal of this article is to identify the determinants of intention to participate in the plasma donation programme among MSM in Montreal, Canada. Materials and methods: Based on the theory of planned behaviour, a questionnaire was developed to measure MSM's intention to donate plasma and identify influencing factors. A multiple linear regression analysis was conducted to identify the determinants of intention to donate plasma. Results: Respondents' (N = 933) intention to donate plasma in the next six months was moderate. The multiple linear regression model explained 55% (P < 0·001) of the variation of intention. Intention was predicted by attitudes (β = 0·34, P < 0·001), perceived behavioural control (β = 0·28, P < 0·001), aged under 35 years (β = 0·26, P < 0·001), history of blood donation (β = 0·24, P < 0·001), subjective norm (β = 0·21, P < 0·001), income above $40,000 (β = 0·20, P < 0·001), moral norm (β = 0·18, P < 0·001) and higher level of involvement in various issues LGBTQ+ communities are fighting for (β = 0·09, P < 0·001). Conclusion: Our analyses show that intention to donate plasma within the proposed programme is associated with personal, social and structural factors, but more strongly predicted by factors related to the theory of planned behaviour. Our results also highlight the importance of involving MSM; community acceptability of the plasma donation programme would probably be higher if MSM felt respected and party to the decisions. [ABSTRACT FROM AUTHOR]

Der Place Ville Marie befindet sich im Herzen von Montreal, direkt am Boulevard René‐Lévesque. Dieser Platz wurde renoviert, um so zu einem der beliebtesten städtischen Treffpunkte Montreals zu werden. Aus den vormals vier Lichtkuppeln wurde ein großer zentraler Eingangspavillon aus Glas geschaffen, der einen direkten Zugang in den daruntergelegenen Bereich bietet. Zur Leistung von seele gehörte die Planung und Montage des 45 × 15 m großen Glasdaches, das sich ca. 1,2 m über dem Boden befindet. Das etwa 680 m2 große Dach besteht aus 15 × 2,5 m großen Isolierglasscheiben. Diese werden von Glasträgern aus 8 × 12 mm Verbundsicherheitsgläsern (VSG) aus teilvorgespanntem Glas (TVG) mit einer Höhe von 900 mm getragen. Im Rahmen des vorliegenden Beitrages werden Besonderheiten der Konstruktion und Montage diskutiert. Für die Verbindungstechnik wird beispielsweise eine Kombination aus Bolzen‐ und Einlaminiertechnik verwendet. Im Eingangsbereich kragen Glasschwerter mehrere Meter aus und stellen damit besondere Anforderungen an die Statik. Um die hohen Schneelasten abzutragen, werden in diesem Sonderbereich 14‐fach‐Laminate verwendet. Design Engineering and Installation of Glass Structures in Canada. The Place Ville Marie is located in the heart of Montreal, directly on the Boulevard René‐Lévesque. This square has been renovated to become one of the most popular urban meeting places in Montreal. The former four dome lights were transformed into a large central glass entrance pavilion that provides direct access to the area below. seele's services included the planning and installation of the 45 × 15 m glass roof, which is located approx. 1.2 m above the ground. The approximately 680 m2 roof consists of 15 m × 2.5 m insulated glass panels. The regular roof panels are supported by 8 × 12 mm laminated safety glass panels with a height of 900 mm. In the context of this article, special features of construction and installation are discussed. For example, a combination of bolting and laminating techniques is used for the joining technique. In the entrance area, glass beams cantilever several metres and thus place special demands on the statics. In order to bear the high snow loads, 14‐ply laminates are used in this special area. [ABSTRACT FROM AUTHOR]