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1. Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene.

Author

Braga, Caroline C. B., Benites, Bruno Deltreggia, Albuquerque, Dulcineia M., Alvarez, Marisa C., Seva‐Pereira, Tiago, Duarte, Bruno K. L., Costa, Fernando F., Gilli, Simone C. O., and Saad, Sara T. O.

Subjects
*SICKLE cell anemia, *HEPATITIS, *LIVER failure, *HEPATOTOXICOLOGY, *PATIENTS, *THERAPEUTICS, THERAPEUTIC use of iron chelates
Abstract

Key Clinical Message This manuscript describes the case of a patient with sickle cell anemia who died of fulminant hepatitis after therapy with the iron chelator Deferasirox. The patient was homozygous for the −1774delG polymorphism in the Abcc2 gene, which raises the concern about the use of hepatotoxic drugs in this specific context. [ABSTRACT FROM AUTHOR]

Published
2017
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