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* Adults aged 21 to 65 with DSM-IV alcohol dependence were randomized to baclofen 30 or 90 mg/day or placebo for 16 weeks. * Baclofen resulted in a reduction in heavy drinking days and an increase in alcohol-abstinent days compared with placebo, with the 90-mg dose showing greater efficacy than the lower dose. * Women did not show as much improvement with the 90-mg dose compared with men., A 16-week randomized trial has found that the GABA agonist baclofen was more effective than placebo in increasing abstinence from alcohol use and in reducing heavy drinking days. The improvements [...]

* Hospitalized patients who required mechanical ventilation and had a history of unhealthy alcohol use were randomized to baclofen or placebo to evaluate the drug's effect on agitation. * A significantly lower percentage of baclofen patients experienced an agitation-related event compared with placebo. * Baclofen patients experienced other adverse outcomes, such as a longer duration of mechanical ventilation and longer stays in intensive care, than placebo patients., High-dose administration of baclofen led to a significant reduction in agitation-related events among hospital patients with an alcohol use history who required mechanical ventilation, a placebo-controlled study has found. However, [...]