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8 results on '"Abiko, K."'

1. Mesonephric-like adenocarcinoma of the ovary in an elderly woman: A case report and a review of the literature.

Author

Ujita M, Abiko K, Kuwahara R, Emoto I, Amano Y, and Konishi I

Subjects
Aged, Aged, 80 and over, Endometrium, Female, Humans, Adenocarcinoma diagnostic imaging, Adenocarcinoma surgery, Ovarian Neoplasms diagnostic imaging, Ovarian Neoplasms surgery, Uterine Cervical Neoplasms
Abstract

Mesonephric-like adenocarcinoma (MLA) is a rare tumor that occurs in the uterine endometrium and ovary. It morphologically and immunohistochemically resembles cervical mesonephric adenocarcinoma (MA). Here, we present a case of MLA of the ovary along with a literature review. An asymptomatic 84-year-old woman presented with a pelvic mass, detected by computerized tomography. Magnetic resonance imaging demonstrated a polycystic mass with a solid component in the left adnexal region. The solid component showed low signal intensity on T2-weighted imaging and high signal intensity on diffusion-weighted imaging. We strongly suspected an ovarian malignant tumor; therefore, surgical resection of the uterus and adnexa was performed. Macroscopically, the tumor was predominantly solid with yellowish-tan cut surface. Microscopically, it showed a tubular pattern with intraluminal colloid-like material resembling MA. The tumor cells were negative for estrogen receptor, calretinin, and CD10 and positive for PAX8 and TTF-1. These findings are consistent with those of MLA., (© 2021 Japan Society of Obstetrics and Gynecology.)

Published
2021
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2. Lymphoepithelioma-like carcinoma of uterine cervix: Preoperative diagnosis and course in three cases.

Author

Ikeda A, Abiko K, Emoto I, Ujita M, Takao Y, and Konishi I

Subjects
Biopsy, Cervix Uteri diagnostic imaging, Cervix Uteri surgery, Female, Humans, Magnetic Resonance Imaging, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms diagnostic imaging, Uterine Cervical Neoplasms surgery
Abstract

Lymphoepithelioma-like carcinoma of the uterine cervix is a rare variant of squamous cell carcinoma. Herein, we describe three cases of lymphoepithelioma-like carcinoma of the uterine cervix and review relevant literature. All three patients initially presented with postmenopausal bleeding. Gross appearances were endophytic with ulcerated mucosa in case 1, exophytic with polypoid morphology in case 2, and unremarkable even using colposcopy and hysteroscopy in case 3. Magnetic resonance imaging demonstrated well-demarcated cervical masses with high-intermediate intensity on T2-weighted images and high intensity on diffusion-weighted images in all three cases. In case 3, biopsy referring to local information from magnetic resonance images was required for preoperative diagnosis. We reviewed the literature of 59 lymphoepithelioma-like carcinoma cases in 19 papers published between 2001 and 2020. Preoperative diagnosis of lymphoepithelioma-like carcinoma is sometimes challenging, although magnetic resonance imaging findings may help determine the location of the tumor and obtain a successful biopsy., (© 2021 Japan Society of Obstetrics and Gynecology.)

Published
2021
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3. Hysteroscopic morphological pattern reflects histological grade of endometrial cancer.

Author

Miyamoto T, Abiko K, Murakami R, Furutake Y, Baba T, Horie A, Hamanishi J, and Mandai M

Subjects
Adult, Aged, Aged, 80 and over, Biopsy, Carcinoma, Endometrioid pathology, Carcinoma, Papillary pathology, Endometrial Hyperplasia pathology, Endometrial Neoplasms pathology, Female, Humans, Hysterectomy, Middle Aged, Carcinoma, Endometrioid diagnosis, Carcinoma, Papillary diagnosis, Endometrial Hyperplasia diagnosis, Endometrial Neoplasms diagnosis, Hysteroscopy
Abstract

Aim: To examine the hysteroscopic morphological features in each histological grade of endometrial cancer, and to distinguish high- and low-grade cancer and low-grade cancer and atypical endometrial hyperplasia (AEH), using hysteroscopy., Methods: In total, 135 patients who underwent hysterectomy after hysteroscopy were analyzed. They were divided into four categories: benign lesion; AEH; low-grade cancer, including endometrioid carcinoma grades 1 and 2 (G1/2); and high-grade cancer, including endometrioid carcinoma grade 3 and other high-grade carcinomas (G3/others). Three blinded gynecologic oncologists independently evaluated hysteroscopic video images for abnormal vessels, surface smoothness, papillary structure and polypoid structure. Prevalence rates of each finding were compared between the four categories. The accuracy of blind biopsy in outpatient settings and hysteroscopic endometrial biopsy in the four categories were also investigated., Results: The number of patients with benign lesions, AEH, G1/2 and G3/others was 8, 7, 84 and 36, respectively. Patients with G3/others exhibited more polypoid (86% vs 61%, P = 0.0095) and less papillary (59% vs 80%, P = 0.023) structures than those exhibited by patients with G1/2. AEH and G1/2 were indistinguishable using hysteroscopy. Hysteroscopic biopsy was more accurate than outpatient biopsy in patients with G3/others (84% vs 52%, respectively, P = 0.010). Both biopsies were not sufficiently accurate to diagnose AEH (outpatient; 0%, hysteroscopic; 57%)., Conclusion: Hysteroscopic papillary and polypoid structures can help distinguish between high- and low-grade cancer. Hysteroscopic differentiation between AEH and low-grade cancer is difficult. These findings are considerable in preoperative assessment to determine adequate surgical strategies., (© 2019 Japan Society of Obstetrics and Gynecology.)

Published
2019
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4. Aggressive adult granulosa cell tumor of the ovary without a FOXL2 mutation: A case report.

Author

Watanabe K, Abiko K, Minamiguchi S, Maeda H, Murakami R, Kitamura S, Horie A, and Mandai M

Subjects
Aged, Female, Humans, Point Mutation, Forkhead Box Protein L2 genetics, Granulosa Cell Tumor genetics
Abstract

We report a case of aggressive adult granulosa cell tumor (AGCT) of the ovary. On presentation, the tumor was localized in the right ovary; a total abdominal hysterectomy, bilateral salpingo-oophorectomy and partial omentectomy were performed. While some areas of the tumor represented typical AGCT, other areas showed enlarged and hyperchromatic nuclei with numerous mitoses (>10/high-power field) with marked necrosis. The results of immunohistochemical analysis were compatible with AGCT, except that, in the necrotic portion, p53 was strongly positive, and the Ki-67 index was high. Four months after laparotomy, recurrent tumors developed in the bones, liver, lungs and dura mater. The patient responded well to chemotherapy consisting of five cycles of paclitaxel and carboplatin, but later, the tumors rapidly proliferated, and the patient died of disease 11 months after laparotomy. FOXL2 examination demonstrated that both portions of the primary tumor did not have a point mutation (402C→G) specific to AGCT., (© 2019 Japan Society of Obstetrics and Gynecology.)

Published
2019
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5. Solitary fibrous tumor arising from pelvic retroperitoneum: A report of two cases and a review of the literature.

Author

Yamada K, Abiko K, Kido A, Minamiguchi S, Horie A, and Mandai M

Subjects
Female, Humans, Middle Aged, Pelvic Neoplasms pathology, Retroperitoneal Space pathology, Solitary Fibrous Tumors pathology
Abstract

Solitary fibrous tumors (SFT) rarely arise in the pelvis. Here, we report two cases of SFT arising from the pelvic retroperitoneum. The first case involves a 64-year-old woman diagnosed with a 5-cm pelvic mass. Magnetic resonance imaging revealed a solid and cystic mass with marked enhancement, but limited water restriction. During surgery, intraligamental tumor arising near the round ligament was resected. Pathologically, the tumor comprised dilated vessels and spindle-shaped cells positive for STAT6 and CD34. The second case involves a 53-year-old woman diagnosed with a 4.5-cm pelvic mass through computed tomography. Magnetic resonance imaging demonstrated a solid mass with multiple cysts with strong enhancement and slight water restriction. During surgery, the tumor was found in the retroperitoneum. Pathologically, spindle-shaped tumor cells positive for STAT6 and CD34 had proliferated around the prominent hyalinized vessels. Although rare in the pelvis, SFT should be suspected when a mass with strong enhancement is found., (© 2019 Japan Society of Obstetrics and Gynecology.)

Published
2019
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6. Case of rapidly progressing condylomatous squamous cell carcinoma of the uterine cervix associated with low-risk human papillomavirus type 6.

Author

Masuda M, Abiko K, Minamiguchi S, Murakami R, Baba T, and Konishi I

Subjects
Adult, Carcinoma, Squamous Cell etiology, Condylomata Acuminata etiology, Female, Humans, Papillomavirus Infections complications, Uterine Cervical Neoplasms etiology, Carcinoma, Squamous Cell diagnosis, Condylomata Acuminata diagnosis, Disease Progression, Human papillomavirus 6 pathogenicity, Papillomavirus Infections diagnosis, Uterine Cervical Neoplasms diagnosis
Abstract

Condylomatous, or warty squamous cell carcinoma (SCC) of the uterine cervix, is a rare variant of invasive SCC. Here, we describe a case of aggressive condylomatous SCC of the uterine cervix. A 43-year-old woman was monitored for 3 years for suspected low-grade squamous intraepithelial lesion. A whitish papillary mass occupied the cervix, and the colposcopic diagnosis was condyloma acuminatum. A cervical biopsy revealed papillary proliferating thick squamous epithelium, which consisted of koilocytes and atypical cells with enlarged nuclei. Hysterectomy specimens showed a thick layer of atypical squamous epithelium with koilocytosis invading the stroma. Immunohistochemistry revealed negative p16 expression. Hysterectomy specimens tested positive for low-risk human papillomavirus type 6, but negative for other high-risk human papillomavirus types. The bilateral pelvic and para-aortic lymph nodes were positive for metastases. In spite of adjuvant chemotherapy, the case relapsed with multiple lymph nodes and lung metastases shortly after the operation., (© 2017 Japan Society of Obstetrics and Gynecology.)

Published
2018
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7. Two cases of Wolffian tumor with novel magnetic resonance imaging findings reflecting characteristic pathology.

Author

Sakai M, Abiko K, Matsumura N, Kondoh E, Yamaguchi K, Minamiguchi S, Kurata Y, Kido A, and Konishi I

Subjects
Abdominal Pain complications, Adnexa Uteri diagnostic imaging, Adnexa Uteri pathology, Adult, Female, Humans, Middle Aged, Postmenopause, Adenoma diagnostic imaging, Adenoma pathology, Adnexal Diseases diagnostic imaging, Adnexal Diseases pathology, Magnetic Resonance Imaging
Abstract

A Wolffian tumor is a rare tumor arising from the remnants of the mesonephric duct. Herein, we report two cases. A 61-year-old woman presented with swollen left adnexa. On T2 weighted magnetic resonance imaging (MRI), a 4.4 cm solid pelvic mass showed slightly high signal intensity, with a low-signal-intensity rim. Microscopically, cuboidal cells with bland nuclei were arranged in a dense tubular form. A 40-year-old woman complained of lower abdominal pain. On T2 weighted MRI, a 6.0 cm solid mass with a low-signal-intensity rim was found. The pathology of the resected tumor was similar to that of case 1. Both cases were diagnosed as Wolffian tumor. The rims of the tumors in both cases were composed of eosinophilic spindle-shaped cells immunoreactive to alpha-smooth muscle actin and desmin, identical to the smooth muscle cells surrounding the mesonephric duct remnants. MRI findings reflecting smooth muscle rims might contribute to an accurate preoperative diagnosis of this rare tumor., (© 2016 Japan Society of Obstetrics and Gynecology.)

Published
2016
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8. Advanced extragonadal yolk sac tumor serially followed up with (18)F-fluorodexyglucose-positoron emission tomography and computerized tomography and serum alpha-fetoprotein.

Author

Baba T, Su S, Umeoka S, Abiko K, Nakamoto Y, Mandai M, Matsumura N, and Konishi I

Subjects
Abdominal Neoplasms blood, Adult, Endodermal Sinus Tumor blood, Female, Humans, Abdominal Neoplasms diagnostic imaging, Endodermal Sinus Tumor diagnostic imaging, Fluorodeoxyglucose F18, Multimodal Imaging, Positron-Emission Tomography, Radiopharmaceuticals, Tomography, X-Ray Computed, alpha-Fetoproteins metabolism
Abstract

Although yolk sac tumors (YSTs) are the second most common malignant germ cell tumor of the ovary, those arising from the omentum or pelvic peritoneum are extremely rare and have no established treatment guidelines. We report a case of a primary YST disseminated throughout the abdomen and associated with a high serum alpha-fetoprotein (AFP) elevation (441 611 ng/ml). Optimal cytoreduction was not achieved in order to preserve the patient's fertility and avoid adjacent organ injury. Residual tumor responded to adjuvant chemotherapy with a sharp decline in AFP levels, and confirmed remission was documented by serial (18)F-fluorodexyglucose-positoron emission tomography and computerized tomography (FDG-PET/CT). In cases of advanced YST with unresectable residual disease, AFP levels combined with FDG-PET/CT scans may be a helpful way to monitor treatment response and assist in treatment planning for a disease that primarily affects young women who may desire to preserve fertility., (© 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.)

Published
2012
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