1. Effects of dopaminergic drugs on cerebellar prostaglandin concentrations.
- Author
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Millia C, Nicoletti F, Grasso AA, Patti F, Condorelli DF, Rapisarda E, Rampello L, Costa G, and Scapagnini U
- Subjects
- Animals, Brain drug effects, Dinoprost, Dinoprostone, Male, Prostaglandins E metabolism, Prostaglandins F metabolism, Rats, Rats, Inbred Strains, Apomorphine pharmacology, Brain metabolism, Haloperidol pharmacology, Prostaglandins metabolism, Sulpiride pharmacology
- Abstract
Previous data indicate that the injection of dopaminergic drugs induces changes in cerebellar 3',5'-guanosine monophosphate (cGMP) content. Accordingly, we have investigated the effects of haloperidol, sulpiride, or apomorphine on cerebellar prostaglandin (PG) concentration, a parameter related to cGMP content. Results obtained show that dopamine receptor blocking agents, such as haloperidol and sulpiride, significantly decrease cerebellar PGE2 and PGF2 alpha concentrations, while opposite changes are induced by apomorphine, a dopamine receptor agonist.
- Published
- 1983
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