1. Dietary total antioxidant capacity is positively associated with muscular strength in cirrhotic outpatients: a cross-sectional study.
- Author
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de Freitas Lima L, de Faria Ghetti F, Hermsdorff HHM, de Oliveira DG, Teixeira G, de Castro Ferreira LEVV, and Moreira APB
- Subjects
- Aged, Anthropometry, Arm physiopathology, Biomarkers analysis, Cross-Sectional Studies, Diet Surveys, Female, Hand Strength physiology, Humans, Male, Middle Aged, Muscle, Skeletal physiopathology, Reactive Oxygen Species metabolism, Severity of Illness Index, Antioxidants analysis, Liver Cirrhosis physiopathology, Muscle Strength drug effects, Outpatients statistics & numerical data, Oxidative Stress drug effects
- Abstract
Background: Cirrhosis is the end-stage of progressive fibrosis, in which oxidative stress and inflammation-related pathways can modulate the cellular and tissue events involved in the pathogenesis of liver fibrosis. Dietary intake of antioxidants has been suggested to protect against oxidative damage and related clinical complications. The present study aimed to investigate the potential association of the dietary total antioxidant capacity (dTAC) with anthropometric, functional and biochemical markers, as well as the severity of the disease, in cirrhotic outpatients., Methods: Sixty-two outpatients (38 men and 24 women) with a mean (SD) age of 59.1 (9.9) years were evaluated. Dietary TAC was estimated from a food frequency questionnaire. Aetiology and severity of liver cirrhosis, lifestyle characteristics, occurrence of comorbidities and oedema, and anthropometric, functional and biochemical markers were all assessed., Results: Cirrhotic outpatients with higher dTAC also had higher values of the hand-grip strength (P = 0.029) and arm muscle area (P = 0.027). After adjusting by sex, age, smoking and alcohol intake, the addition of 1 mmol day
-1 of dTAC contributed to increase 0.552 kg f-1 in hand-grip strength (P < 0.05). The addition of one mmol day-1 of dTAC contributed to an arm muscle area increase 0.565 cm2 (P < 0.05) on average., Conclusions: The dTAC was positively associated with hand-grip strength and arm muscle area in cirrhotic outpatients. The implications of the present study are important in clinical practice because a diet rich in antioxidants may be an ally in the control of excessive reactive oxygen species production in cirrhotic outpatients with repercussion on muscle mass and strength., (© 2019 The British Dietetic Association Ltd.)- Published
- 2020
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