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32 results on '"van Deerlin, Vivianna M."'

1. GPNMB Biomarker Levels in GBA1 Carriers with Lewy Body Disorders

Author

Brody, Eliza M., primary, Seo, Yunji, additional, Suh, EunRan, additional, Amari, Noor, additional, Hartstone, Whitney G., additional, Skrinak, R. Tyler, additional, Zhang, Hanwen, additional, Diaz‐Ortiz, Maria E., additional, Weintraub, Daniel, additional, Tropea, Thomas F., additional, Van Deerlin, Vivianna M., additional, and Chen‐Plotkin, Alice S., additional

Published
2024
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3. Abundant copathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP‐43 inclusions and ageing‐related tau astrogliopathy in a family with a GBE1 mutation

Author

Uemura, Maiko T., primary, Suh, Eun Ran, additional, Robinson, John L., additional, Brunden, Kurt R., additional, Grossman, Murray, additional, Irwin, David J., additional, Lee, Virginia M.‐Y., additional, Trojanowski, John Q., additional, Lee, Edward B., additional, and Van Deerlin, Vivianna M., additional

Published
2023
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5. Characterizing Amyloid Responsive Microglia in a Cognitively Resilient Patient with Alzheimer’s Disease Neuropathologic Change: A Case Report

Author

Nguyen, Aivi T., primary, Przybelski, Scott A., additional, Lesnick, Timothy G., additional, Ramanan, Vijay K, additional, Petersen, Ronald C., additional, Graff‐Radford, Jonathan, additional, Knopman, David S., additional, Jack, Clifford R., additional, Dickson, Dennis W., additional, Van Deerlin, Vivianna M, additional, Lee, Eddie B, additional, Reichard, Ross R., additional, and Vemuri, Prashanthi, additional

Published
2022
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6. Plasma GFAP:NfL discriminates FTLD‐tau from FTLD‐TDP

Author

Cousins, Katheryn A Q, primary, Shaw, Leslie M., additional, Chen‐Plotkin, Alice, additional, Lee, Eddie B, additional, Trojanowski, John Q, additional, Van Deerlin, Vivianna M, additional, McMillan, Corey T, additional, Grossman, Murray, additional, and Irwin, David J., additional

Published
2022
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7. Plasma MIA , CRP , and Albumin Predict Cognitive Decline in Parkinson's Disease

Author

Shen, Junchao, primary, Amari, Noor, additional, Zack, Rebecca, additional, Skrinak, R. Tyler, additional, Unger, Travis L., additional, Posavi, Marijan, additional, Tropea, Thomas F., additional, Xie, Sharon X., additional, Van Deerlin, Vivianna M., additional, Dewey, Richard B., additional, Weintraub, Daniel, additional, Trojanowski, John Q., additional, and Chen‐Plotkin, Alice S., additional

Published
2022
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8. Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts

Author

Iwaki, Hirotaka, Blauwendraat, Cornelis, Leonard, Hampton L, Kim, Jonggeol J, Liu, Ganqiang, Maple-Grødem, Jodi, Corvol, Jean-Christophe, Pihlstrøm, Lasse, van Nimwegen, Marlies, Hutten, Samantha J, Nguyen, Khanh-Dung H, Rick, Jacqueline, Eberly, Shirley, Faghri, Faraz, Auinger, Peggy, Scott, Kirsten M, Wijeyekoon, Ruwani, Van Deerlin, Vivianna M, Hernandez, Dena G, Gibbs, J Raphael, International Parkinson's Disease Genomics Consortium, Chitrala, Kumaraswamy Naidu, Day-Williams, Aaron G, Brice, Alexis, Alves, Guido, Noyce, Alastair J, Tysnes, Ole-Bjørn, Evans, Jonathan R, Breen, David P, Estrada, Karol, Wegel, Claire E, Danjou, Fabrice, Simon, David K, Andreassen, Ole, Ravina, Bernard, Toft, Mathias, Heutink, Peter, Bloem, Bastiaan R, Weintraub, Daniel, Barker, Roger A, Williams-Gray, Caroline H, van de Warrenburg, Bart P, Van Hilten, Jacobus J, Scherzer, Clemens R, Singleton, Andrew B, Nalls, Mike A, Barker, Roger [0000-0001-8843-7730], Williams-Gray, Caroline [0000-0002-2648-9743], and Apollo - University of Cambridge Repository

Subjects
Adult, Aged, 80 and over, Male, Organic Cation Transport Proteins, Parkinson's disease, Parkinson Disease, Middle Aged, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Risk Assessment, Cohort Studies, Cross-Sectional Studies, Phenotype, Antigens, CD, Disease Progression, Glucosylceramidase, Humans, GBA, Cognitive Dysfunction, Female, Apolipoprotein E, Longitudinal Studies, genomewide association study, Biomarkers, Aged, Genome-Wide Association Study
Abstract

BACKGROUND: Several reports have identified different patterns of Parkinson's disease progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall contribution of genetic factors to the severity and progression of Parkinson's disease, however, has not been well studied. OBJECTIVES: To test the association between genetic variants and the clinical features of Parkinson's disease on a genomewide scale. METHODS: We accumulated individual data from 12 longitudinal cohorts in a total of 4093 patients with 22,307 observations for a median of 3.81 years. Genomewide associations were evaluated for 25 cross-sectional and longitudinal phenotypes. Specific variants of interest, including 90 recently identified disease-risk variants, were also investigated post hoc for candidate associations with these phenotypes. RESULTS: Two variants were genomewide significant. Rs382940(T>A), within the intron of SLC44A1, was associated with reaching Hoehn and Yahr stage 3 or higher faster (hazard ratio 2.04 [1.58-2.62]; P value = 3.46E-8). Rs61863020(G>A), an intergenic variant and expression quantitative trait loci for α-2A adrenergic receptor, was associated with a lower prevalence of insomnia at baseline (odds ratio 0.63 [0.52-0.75]; P value = 4.74E-8). In the targeted analysis, we found 9 associations between known Parkinson's risk variants and more severe motor/cognitive symptoms. Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients. CONCLUSIONS: We identified novel genetic factors associated with heterogeneity of Parkinson's disease. The results can be used for validation or hypothesis tests regarding Parkinson's disease. © 2019 International Parkinson and Movement Disorder Society.

Published
2019

9. Differences in the Presentation and Progression of Parkinson's Disease by Sex

Author

Iwaki, Hirotaka, primary, Blauwendraat, Cornelis, additional, Leonard, Hampton L., additional, Makarious, Mary B., additional, Kim, Jonggeol J., additional, Liu, Ganqiang, additional, Maple‐Grødem, Jodi, additional, Corvol, Jean‐Christophe, additional, Pihlstrøm, Lasse, additional, van Nimwegen, Marlies, additional, Smolensky, Luba, additional, Amondikar, Ninad, additional, Hutten, Samantha J., additional, Frasier, Mark, additional, Nguyen, Khanh‐Dung H., additional, Rick, Jacqueline, additional, Eberly, Shirley, additional, Faghri, Faraz, additional, Auinger, Peggy, additional, Scott, Kirsten M., additional, Wijeyekoon, Ruwani, additional, Van Deerlin, Vivianna M., additional, Hernandez, Dena G., additional, Gibbs, Raphael J., additional, Day‐Williams, Aaron G., additional, Brice, Alexis, additional, Alves, Guido, additional, Noyce, Alastair J., additional, Tysnes, Ole‐Bjørn, additional, Evans, Jonathan R., additional, Breen, David P., additional, Estrada, Karol, additional, Wegel, Claire E., additional, Danjou, Fabrice, additional, Simon, David K., additional, Andreassen, Ole A., additional, Ravina, Bernard, additional, Toft, Mathias, additional, Heutink, Peter, additional, Bloem, Bastiaan R., additional, Weintraub, Daniel, additional, Barker, Roger A., additional, Williams‐Gray, Caroline H., additional, van de Warrenburg, Bart P., additional, Van Hilten, Jacobus J., additional, Scherzer, Clemens R., additional, Singleton, Andrew B., additional, and Nalls, Mike A., additional

Published
2020
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14. CEREBROSPINAL FLUID ENDOPHENOTYPES PROVIDE INSIGHT INTO BIOLOGY UNDERLYING ALZHEIMER'S DISEASE

Author

Deming, Yuetiva, primary, Kapoor, Manav, additional, Li, Zeran, additional, Harari, Oscar, additional, Black, Kathleen, additional, Del-Aguila, Jorge L., additional, Carrell, David, additional, Cai, Yefei, additional, Fernandez, Maria Victoria, additional, Budde, John P., additional, Ma, Shengmei, additional, Saef, Benjamin, additional, Howells, Bill, additional, Huang, Kuan-lin, additional, Bertelsen, Sarah, additional, Fagan, Anne M., additional, Holtzman, David M., additional, Morris, John C., additional, Kim, Sungeun, additional, Saykin, Andrew J., additional, De Jager, Philip L., additional, Albert, Marilyn S., additional, Moghekar, Abhay, additional, o'Brien, Richard, additional, Riemenschneider, Matthias, additional, Petersen, Ronald C., additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Minthon, Lennart, additional, Van Deerlin, Vivianna M., additional, M-Y Lee, Virginia, additional, Shaw, Leslie M., additional, Trojanowski, John Q., additional, Schellenberg, Gerard D., additional, Haines, Jonathan L., additional, Mayeux, Richard, additional, Pericak-Vance, Margaret A., additional, Farrer, Lindsay A., additional, Peskind, Elaine R., additional, Li, Ge, additional, Molinuevo, José Luis, additional, Lleó, Alberto, additional, Clarimon, Jordi, additional, Pastor, Pau, additional, Di Narzo, Antonio, additional, Piccio, Laura, additional, Kauwe, John, additional, Goate, Alison M., additional, and Cruchaga, Carlos, additional

Published
2017
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15. Transethnic genome‐wide scan identifies novel Alzheimer's disease loci

Author

Jun, Gyungah R., primary, Chung, Jaeyoon, additional, Mez, Jesse, additional, Barber, Robert, additional, Beecham, Gary W., additional, Bennett, David A., additional, Buxbaum, Joseph D., additional, Byrd, Goldie S., additional, Carrasquillo, Minerva M., additional, Crane, Paul K., additional, Cruchaga, Carlos, additional, De Jager, Philip, additional, Ertekin‐Taner, Nilufer, additional, Evans, Denis, additional, Fallin, M. Danielle, additional, Foroud, Tatiana M., additional, Friedland, Robert P., additional, Goate, Alison M., additional, Graff‐Radford, Neill R., additional, Hendrie, Hugh, additional, Hall, Kathleen S., additional, Hamilton‐Nelson, Kara L., additional, Inzelberg, Rivka, additional, Kamboh, M. Ilyas, additional, Kauwe, John S.K., additional, Kukull, Walter A., additional, Kunkle, Brian W., additional, Kuwano, Ryozo, additional, Larson, Eric B., additional, Logue, Mark W., additional, Manly, Jennifer J., additional, Martin, Eden R., additional, Montine, Thomas J., additional, Mukherjee, Shubhabrata, additional, Naj, Adam, additional, Reiman, Eric M., additional, Reitz, Christiane, additional, Sherva, Richard, additional, St. George‐Hyslop, Peter H., additional, Thornton, Timothy, additional, Younkin, Steven G., additional, Vardarajan, Badri N., additional, Wang, Li‐San, additional, Wendlund, Jens R., additional, Winslow, Ashley R., additional, Adams, Perrie M., additional, Albert, Marilyn S., additional, Albin, Roger L., additional, Apostolova, Liana G., additional, Arnold, Steven E., additional, Asthana, Sanjay, additional, Atwood, Craig S., additional, Barmada, Michjael M., additional, Barnes, Lisa L., additional, Beach, Thomas G., additional, Becker, James T., additional, Bigio, Eileen H., additional, Bird, Thomas D., additional, Blacker, Deborah, additional, Boeve, Bradley F., additional, Bowen, James D., additional, Boxer, Adam, additional, Burke, James R., additional, Cairns, Nigel J., additional, Cao, Chuanhai, additional, Carlson, Chris S., additional, Carlsson, Cynthia M., additional, Carney, Regina M., additional, Carroll, Steven L., additional, Chui, Helena C., additional, Clark, David G., additional, Corneveaux, Jason, additional, Cribbs, David H., additional, Crocco, Elizabeth A., additional, De Jager, Philip L., additional, DeCarli, Charles, additional, DeKosky, Steven T., additional, Demirci, F. Yesim, additional, Dick, Malcolm, additional, Dickson, Dennis W., additional, Doody, Rachelle S., additional, Duara, Ranjan, additional, Faber, Kelley M., additional, Fairchild, Thomas J., additional, Fallon, Kenneth B., additional, Farlow, Martin R., additional, Ferris, Steven, additional, Frosch, Matthew P., additional, Galasko, Douglas R., additional, Gearing, Marla, additional, Geschwind, Daniel H., additional, Ghetti, Bernardino, additional, Gilbert, John R., additional, Glass, Jonathan D., additional, Green, Robert C., additional, Growdon, John H., additional, Hakonarson, Hakon, additional, Hamilton, Ronald L., additional, Hardy, John, additional, Harrell, Lindy E., additional, Head, Elizabeth, additional, Honig, Lawrence S., additional, Huebinger, Ryan M., additional, Huentelman, Matthew J., additional, Hulette, Christine M., additional, Hyman, Bradley T., additional, Jarvik, Gail P., additional, Jicha, Gregory A., additional, Jin, Lee‐Way, additional, Karydas, Anna, additional, Kaye, Jeffrey A., additional, Kim, Ronald, additional, Koo, Edward H., additional, Kowall, Neil W., additional, Kramer, Joel H., additional, LaFerla, Frank M., additional, Lah, James J., additional, Leverenz, James B., additional, Levey, Allan I., additional, Li, Ge, additional, Lieberman, Andrew P., additional, Lin, Chiao‐Feng, additional, Lopez, Oscar L., additional, Lyketsos, Constantine G., additional, Mack, Wendy J., additional, Marson, Daniel C., additional, Martiniuk, Frank, additional, Mash, Deborah C., additional, Masliah, Eliezer, additional, McCormick, Wayne C., additional, McCurry, Susan M., additional, McDavid, Andrew N., additional, McKee, Ann C., additional, Mesulam, Marsel, additional, Miller, Bruce L., additional, Miller, Carol A., additional, Miller, Joshua W., additional, Morris, John C., additional, Murrell, Jill R., additional, Myers, Amanda J., additional, O'Bryant, Sid, additional, Olichney, John M., additional, Pankratz, Vernon S., additional, Parisi, Joseph E., additional, Partch, Amanda, additional, Paulson, Henry L., additional, Perry, William, additional, Peskind, Elaine, additional, Petersen, Ronald C., additional, Pierce, Aimee, additional, Poon, Wayne W., additional, Potter, Huntington, additional, Quinn, Joseph F., additional, Raj, Ashok, additional, Raskind, Murray, additional, Reisberg, Barry, additional, Reisch, Joan S., additional, Ringman, John M., additional, Roberson, Erik D., additional, Rogaeva, Ekaterina, additional, Rosen, Howard J., additional, Rosenberg, Roger N., additional, Royall, Donald R., additional, Sager, Mark A., additional, Sano, Mary, additional, Saykin, Andrew J., additional, Schneider, Julie A., additional, Schneider, Lon S., additional, Seeley, William W., additional, Smith, Amanda G., additional, Sonnen, Joshua A., additional, Spina, Salvatore, additional, Stern, Robert A., additional, Tanzi, Rudolph E., additional, Thornton‐Wells, Tricia A., additional, Trojanowski, John Q., additional, Troncoso, Juan C., additional, Tsuang, Debby W., additional, Van Deerlin, Vivianna M., additional, Van Eldik, Linda J., additional, Vinters, Harry V., additional, Vonsattel, Jean Paul, additional, Weintraub, Sandra, additional, Welsh‐Bohmer, Kathleen A., additional, Williamson, Jennifer, additional, Wishnek, Sarah, additional, Woltjer, Randall L., additional, Wright, Clinton B., additional, Wu, Chuang‐Kuo, additional, Yu, Chang‐En, additional, Yu, Lei, additional, Zhang, Xiaoling, additional, Haines, Jonathan, additional, Mayeux, Richard, additional, Pericak‐Vance, Margaret A., additional, Schellenberg, Gerard, additional, Lunetta, Kathryn L., additional, and Farrer, Lindsay A., additional

Published
2017
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17. Common variant rs356182 near SNCA defines a Parkinson's disease endophenotype

Author

Cooper, Christine A., primary, Jain, Nimansha, additional, Gallagher, Michael D., additional, Weintraub, Daniel, additional, Xie, Sharon X., additional, Berlyand, Yosef, additional, Espay, Alberto J., additional, Quinn, Joseph, additional, Edwards, Karen L., additional, Montine, Thomas, additional, Van Deerlin, Vivianna M., additional, Trojanowski, John, additional, Zabetian, Cyrus P., additional, and Chen-Plotkin, Alice S., additional

Published
2016
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18. Deep clinical and neuropathological phenotyping of Pick disease

Author

Irwin, David J., primary, Brettschneider, Johannes, additional, McMillan, Corey T., additional, Cooper, Felicia, additional, Olm, Christopher, additional, Arnold, Steven E., additional, Van Deerlin, Vivianna M., additional, Seeley, William W., additional, Miller, Bruce L., additional, Lee, Edward B., additional, Lee, Virginia M.-Y., additional, Grossman, Murray, additional, and Trojanowski, John Q., additional

Published
2015
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19. GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease

Author

Mata, Ignacio F., primary, Leverenz, James B., additional, Weintraub, Daniel, additional, Trojanowski, John Q., additional, Chen‐Plotkin, Alice, additional, Van Deerlin, Vivianna M., additional, Ritz, Beate, additional, Rausch, Rebecca, additional, Factor, Stewart A., additional, Wood‐Siverio, Cathy, additional, Quinn, Joseph F., additional, Chung, Kathryn A., additional, Peterson‐Hiller, Amie L., additional, Goldman, Jennifer G., additional, Stebbins, Glenn T., additional, Bernard, Bryan, additional, Espay, Alberto J., additional, Revilla, Fredy J., additional, Devoto, Johnna, additional, Rosenthal, Liana S., additional, Dawson, Ted M., additional, Albert, Marilyn S., additional, Tsuang, Debby, additional, Huston, Haley, additional, Yearout, Dora, additional, Hu, Shu‐Ching, additional, Cholerton, Brenna A., additional, Montine, Thomas J., additional, Edwards, Karen L., additional, and Zabetian, Cyrus P., additional

Published
2015
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20. Cognitive profile of LRRK2‐related Parkinson's disease

Author

Srivatsal, Sindhu, primary, Cholerton, Brenna, additional, Leverenz, James B., additional, Wszolek, Zbigniew K., additional, Uitti, Ryan J., additional, Dickson, Dennis W., additional, Weintraub, Daniel, additional, Trojanowski, John Q., additional, Van Deerlin, Vivianna M., additional, Quinn, Joseph F., additional, Chung, Kathryn A., additional, Peterson, Amie L., additional, Factor, Stewart A., additional, Wood‐Siverio, Cathy, additional, Goldman, Jennifer G., additional, Stebbins, Glenn T., additional, Bernard, Bryan, additional, Ritz, Beate, additional, Rausch, Rebecca, additional, Espay, Alberto J., additional, Revilla, Fredy J., additional, Devoto, Johnna, additional, Rosenthal, Liana S., additional, Dawson, Ted M., additional, Albert, Marilyn S., additional, Mata, Ignacio F., additional, Hu, Shu‐Ching, additional, Montine, Kathleen S., additional, Johnson, Catherine, additional, Montine, Thomas J., additional, Edwards, Karen L., additional, Zhang, Jing, additional, and Zabetian, Cyrus P., additional

Published
2015
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21. Lower plasma apolipoprotein A1 levels are found in Parkinson's disease and associate with apolipoprotein A1 genotype

Author

Swanson, Christine R., primary, Li, Katherine, additional, Unger, Travis L., additional, Gallagher, Michael D., additional, Van Deerlin, Vivianna M., additional, Agarwal, Pinky, additional, Leverenz, James, additional, Roberts, John, additional, Samii, Ali, additional, Gross, Rachel Goldmann, additional, Hurtig, Howard, additional, Rick, Jacqueline, additional, Weintraub, Daniel, additional, Trojanowski, John Q., additional, Zabetian, Cyrus, additional, and Chen-Plotkin, Alice S., additional

Published
2014
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22. C9orf72andUNC13Aare shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: A genome-wide meta-analysis

Author

Diekstra, Frank P., primary, Van Deerlin, Vivianna M., additional, van Swieten, John C., additional, Al-Chalabi, Ammar, additional, Ludolph, Albert C., additional, Weishaupt, Jochen H., additional, Hardiman, Orla, additional, Landers, John E., additional, Brown, Robert H., additional, van Es, Michael A., additional, Pasterkamp, R. Jeroen, additional, Koppers, Max, additional, Andersen, Peter M., additional, Estrada, Karol, additional, Rivadeneira, Fernando, additional, Hofman, Albert, additional, Uitterlinden, André G., additional, van Damme, Philip, additional, Melki, Judith, additional, Meininger, Vincent, additional, Shatunov, Aleksey, additional, Shaw, Christopher E., additional, Leigh, P. Nigel, additional, Shaw, Pamela J., additional, Morrison, Karen E., additional, Fogh, Isabella, additional, Chiò, Adriano, additional, Traynor, Bryan J., additional, Czell, David, additional, Weber, Markus, additional, Heutink, Peter, additional, de Bakker, Paul I. W., additional, Silani, Vincenzo, additional, Robberecht, Wim, additional, van den Berg, Leonard H., additional, and Veldink, Jan H., additional

Published
2014
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23. A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank

Author

Toledo, Jon B., primary, Van Deerlin, Vivianna M., additional, Lee, Edward B., additional, Suh, EunRan, additional, Baek, Young, additional, Robinson, John L., additional, Xie, Sharon X., additional, McBride, Jennifer, additional, Wood, Elisabeth M., additional, Schuck, Theresa, additional, Irwin, David J., additional, Gross, Rachel G., additional, Hurtig, Howard, additional, McCluskey, Leo, additional, Elman, Lauren, additional, Karlawish, Jason, additional, Schellenberg, Gerard, additional, Chen‐Plotkin, Alice, additional, Wolk, David, additional, Grossman, Murray, additional, Arnold, Steven E., additional, Shaw, Leslie M., additional, Lee, Virginia M.‐Y., additional, and Trojanowski, John Q., additional

Published
2013
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24. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis

Author

Brettschneider, Johannes, primary, Del Tredici, Kelly, additional, Toledo, Jon B., additional, Robinson, John L., additional, Irwin, David J., additional, Grossman, Murray, additional, Suh, EunRan, additional, Van Deerlin, Vivianna M., additional, Wood, Elisabeth M., additional, Baek, Young, additional, Kwong, Linda, additional, Lee, Edward B., additional, Elman, Lauren, additional, McCluskey, Leo, additional, Fang, Lubin, additional, Feldengut, Simone, additional, Ludolph, Albert C., additional, Lee, Virginia M.-Y., additional, Braak, Heiko, additional, and Trojanowski, John Q., additional

Published
2013
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25. S5-02-04: Relationships of cerebrovascular atherosclerosis with amyloid, tau, α-synuclein and TDP-43 pathologies in neurodegenerative disease dementias

Author

Yarchoan, Mark, primary, Xie, Sharon X., additional, Kling, Mitchel A., additional, Toledo, Juan B., additional, Wolk, David A., additional, Lee, Edward B., additional, Van Deerlin, Vivianna M., additional, Virginia, M.-Y. Lee, additional, Trojanowski, John Q., additional, and Arnold, Steven E., additional

Published
2012
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27. Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease

Author

Chen-Plotkin, Alice S., primary, Hu, William T., additional, Siderowf, Andrew, additional, Weintraub, Daniel, additional, Goldmann Gross, Rachel, additional, Hurtig, Howard I., additional, Xie, Sharon X., additional, Arnold, Steven E., additional, Grossman, Murray, additional, Clark, Christopher M., additional, Shaw, Leslie M., additional, McCluskey, Leo, additional, Elman, Lauren, additional, Van Deerlin, Vivianna M., additional, Lee, Virginia M.-Y., additional, Soares, Holly, additional, and Trojanowski, John Q., additional

Published
2010
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29. A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro

Author

Winton, Matthew J., primary, Van Deerlin, Vivianna M., additional, Kwong, Linda K., additional, Yuan, Wuxing, additional, Wood, Elisabeth McCarty, additional, Yu, Chang-En, additional, Schellenberg, Gerard D., additional, Rademakers, Rosa, additional, Caselli, Richard, additional, Karydas, Anna, additional, Trojanowski, John Q., additional, Miller, Bruce L., additional, and Lee, Virginia M.-Y., additional

Published
2008
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32. Differences in the Presentation and Progression of Parkinson's Disease by Sex

Author

Iwaki, Hirotaka, Blauwendraat, Cornelis, Leonard, Hampton L, Makarious, Mary B, Kim, Jonggeol J, Liu, Ganqiang, Maple-Grødem, Jodi, Corvol, Jean-Christophe, Pihlstrøm, Lasse, Van Nimwegen, Marlies, Smolensky, Luba, Amondikar, Ninad, Hutten, Samantha J, Frasier, Mark, Nguyen, Khanh-Dung H, Rick, Jacqueline, Eberly, Shirley, Faghri, Faraz, Auinger, Peggy, Scott, Kirsten M, Wijeyekoon, Ruwani, Van Deerlin, Vivianna M, Hernandez, Dena G, Gibbs, Raphael J, Day-Williams, Aaron G, Brice, Alexis, Alves, Guido, Noyce, Alastair J, Tysnes, Ole-Bjørn, Evans, Jonathan R, Breen, David P, Estrada, Karol, Wegel, Claire E, Danjou, Fabrice, Simon, David K, Andreassen, Ole A, Ravina, Bernard, Toft, Mathias, Heutink, Peter, Bloem, Bastiaan R, Weintraub, Daniel, Barker, Roger A, Williams-Gray, Caroline H, Van De Warrenburg, Bart P, Van Hilten, Jacobus J, Scherzer, Clemens R, Singleton, Andrew B, and Nalls, Mike A

Subjects
Cohort Studies, Male, Parkinson's disease, gender, sex, dyskinesias, cognitive impairment, activities of daily livings, Activities of Daily Living, Disease Progression, Humans, Cognitive Dysfunction, Female, Parkinson Disease, 3. Good health
Abstract

BACKGROUND: Previous studies reported various symptoms of Parkinson's disease (PD) associated with sex. Some were conflicting or confirmed in only one study. OBJECTIVES: We examined sex associations to PD phenotypes cross-sectionally and longitudinally in large-scale data. METHODS: We tested 40 clinical phenotypes, using longitudinal, clinic-based patient cohorts, consisting of 5946 patients, with a median follow-up of 3.1 years. For continuous outcomes, we used linear regressions at baseline to test sex-associated differences in presentation, and linear mixed-effects models to test sex-associated differences in progression. For binomial outcomes, we used logistic regression models at baseline and Cox regression models for survival analyses. We adjusted for age, disease duration, and medication use. In the secondary analyses, data from 17 719 PD patients and 7588 non-PD participants from an online-only, self-assessment PD cohort were cross-sectionally evaluated to determine whether the sex-associated differences identified in the primary analyses were consistent and unique to PD. RESULTS: Female PD patients had a higher risk of developing dyskinesia early during the follow-up period, with a slower progression in activities of daily living difficulties, and a lower risk of developing cognitive impairments compared with male patients. The findings in the longitudinal, clinic-based cohorts were mostly consistent with the results of the online-only cohort. CONCLUSIONS: We observed sex-associated contributions to PD heterogeneity. These results highlight the necessity of future research to determine the underlying mechanisms and importance of personalized clinical management. © 2020 International Parkinson and Movement Disorder Society.

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