Search

Your search keyword '"van Wijngaarden, Peter"' showing total 22 results
Start Over Author "van Wijngaarden, Peter" Publisher wiley
22 results on '"van Wijngaarden, Peter"'

4. Impact of the COVID‐19 pandemic and lockdown restrictions on psychosocial and behavioural outcomes among Australian adults with type 2 diabetes: Findings from the PREDICT cohort study

Author

Sacre, Julian W., primary, Holmes‐Truscott, Elizabeth, additional, Salim, Agus, additional, Anstey, Kaarin J., additional, Drummond, Grant R., additional, Huxley, Rachel R., additional, Magliano, Dianna J., additional, van Wijngaarden, Peter, additional, Zimmet, Paul Z., additional, Speight, Jane, additional, and Shaw, Jonathan E., additional

Published
2021
Full Text
View/download PDF

5. A retinal hyperspectral imaging biomarker for Alzheimer’s disease: Preliminary study of the influence of eye diseases on imaging scores

Author

van Wijngaarden, Peter, primary, Hui, Flora, additional, Dang, Darvy, additional, Ha, Jason, additional, Fowler, Christopher J, additional, Villemagne, Victor LL, additional, Rowe, Christopher C, additional, Masters, Colin L, additional, Williamson, Robert, additional, Crowston, Jonathan G, additional, and Hadoux, Xavier, additional

Published
2020
Full Text
View/download PDF

6. Retinal imaging in Alzheimer's and neurodegenerative diseases

Author

Snyder, Peter J., primary, Alber, Jessica, additional, Alt, Clemens, additional, Bain, Lisa J., additional, Bouma, Brett E., additional, Bouwman, Femke H., additional, DeBuc, Delia Cabrera, additional, Campbell, Melanie C.W., additional, Carrillo, Maria C., additional, Chew, Emily Y., additional, Cordeiro, M. Francesca, additional, Dueñas, Michael R., additional, Fernández, Brian M., additional, Koronyo‐Hamaoui, Maya, additional, La Morgia, Chiara, additional, Carare, Roxana O’, additional, Sadda, Srinivas R., additional, van Wijngaarden, Peter, additional, and Snyder, Heather M., additional

Published
2020
Full Text
View/download PDF

14. MODELLING ALZHEIMER’S DISEASE USING HUMAN CORTICAL CEREBRAL ORGANOIDS

Author

Hernández, Damián, primary, Crombie, Duncan E., additional, Liang, Helena H., additional, Kearns, Lisa, additional, Ng, Sze W., additional, de Smit, Elizabeth, additional, Clarke, Linda, additional, Vickers, James C., additional, Van Wijngaarden, Peter, additional, Hewitt, Alex W., additional, and Pébay, Alice, additional

Published
2017
Full Text
View/download PDF

22. Amyloid precursor protein-mediated mitochondrial regulation and Alzheimer's disease.

Author

Lopez Sanchez MIG, van Wijngaarden P, and Trounce IA

Subjects
Animals, Energy Metabolism, Humans, Alzheimer Disease metabolism, Amyloid beta-Protein Precursor metabolism, Mitochondria metabolism
Abstract

Despite clear evidence of a neuroprotective physiological role of amyloid precursor protein (APP) and its non-amyloidogenic processing products, APP has been investigated mainly in animal and cellular models of amyloid pathology in the context of Alzheimer's disease. The rare familial mutations in APP and presenilin-1/2, which sometimes drive increased amyloid β (Aβ) production, may have unduly influenced Alzheimer's disease research. APP and its cleavage products play important roles in cellular and mitochondrial metabolism, but many studies focus solely on Aβ. Mitochondrial bioenergetic metabolism is essential for neuronal function, maintenance and survival, and multiple reports indicate mitochondrial abnormalities in patients with Alzheimer's disease. In this review, we focus on mitochondrial abnormalities reported in sporadic Alzheimer's disease patients and the role of full-length APP and its non-amyloidogenic fragments, particularly soluble APPα, on mitochondrial bioenergetic metabolism. We do not review the plethora of animal and in vitro studies using mutant APP/presenilin constructs or experiments using exogenous Aβ. In doing so, we aim to invigorate research and discussion around non-amyloidogenic APP processing products and the mechanisms linking mitochondria and complex neurodegenerative disorders such as sporadic Alzheimer's disease. LINKED ARTICLES: This article is part of a themed section on Therapeutics for Dementia and Alzheimer's Disease: New Directions for Precision Medicine. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.18/issuetoc., (© 2018 The British Pharmacological Society.)

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results