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3 results on '"psychosis spectrum"'

1. Intracranial and subcortical volumes in adolescents with early-onset psychosis: A multisite mega-analysis from the ENIGMA consortium

Author

Gurholt, TP, Lonning, V, Nerland, S, Jørgensen, KN, Haukvik, UK, Alloza, C, Arango, C, Barth, C, Bearden, CE, Berk, Michael, Bohman, H, Dandash, O, Díaz-Caneja, CM, Edbom, CT, van Erp, TGM, Fett, AKJ, Frangou, S, Goldstein, BI, Grigorian, A, Jahanshad, N, James, AC, Janssen, J, Johannessen, C, Karlsgodt, KH, Kempton, MJ, Kochunov, P, Krabbendam, L, Kyriakopoulos, M, Lundberg, M, MacIntosh, BJ, Rund, BR, Smelror, RE, Sultan, A, Tamnes, CK, Thomopoulos, SI, Vajdi, A, Wedervang-Resell, K, Myhre, AM, Andreassen, OA, Thompson, PM, Agartz, I, Gurholt, TP, Lonning, V, Nerland, S, Jørgensen, KN, Haukvik, UK, Alloza, C, Arango, C, Barth, C, Bearden, CE, Berk, Michael, Bohman, H, Dandash, O, Díaz-Caneja, CM, Edbom, CT, van Erp, TGM, Fett, AKJ, Frangou, S, Goldstein, BI, Grigorian, A, Jahanshad, N, James, AC, Janssen, J, Johannessen, C, Karlsgodt, KH, Kempton, MJ, Kochunov, P, Krabbendam, L, Kyriakopoulos, M, Lundberg, M, MacIntosh, BJ, Rund, BR, Smelror, RE, Sultan, A, Tamnes, CK, Thomopoulos, SI, Vajdi, A, Wedervang-Resell, K, Myhre, AM, Andreassen, OA, Thompson, PM, and Agartz, I

Published
2022

2. Intracranial and subcortical volumes in adolescents with early‐onset psychosis : A multisite mega‐analysis from the ENIGMA consortium

Author

Gurholt, Tiril P., Lonning, Vera, Nerland, Stener, Jørgensen, Kjetil N., Haukvik, Unn K., Alloza, Clara, Arango, Celso, Barth, Claudia, Bearden, Carrie E., Berk, Michael, Bohman, Hannes, Dandash, Orwa, Díaz‐Caneja, Covadonga M., Edbom, Carl T., Erp, Theo G. M., Fett, Anne‐Kathrin J., Frangou, Sophia, Goldstein, Benjamin I., Grigorian, Anahit, Jahanshad, Neda, James, Anthony C., Janssen, Joost, Johannessen, Cecilie, Karlsgodt, Katherine H., Kempton, Matthew J., Kochunov, Peter, Krabbendam, Lydia, Kyriakopoulos, Marinos, Lundberg, Mathias, MacIntosh, Bradley J., Rund, Bjørn Rishovd, Smelror, Runar E., Sultan, Alysha, Tamnes, Christian K., Thomopoulos, Sophia I., Vajdi, Ariana, Wedervang‐Resell, Kirsten, Myhre, Anne M., Andreassen, Ole A., Thompson, Paul M., Agartz, Ingrid, Gurholt, Tiril P., Lonning, Vera, Nerland, Stener, Jørgensen, Kjetil N., Haukvik, Unn K., Alloza, Clara, Arango, Celso, Barth, Claudia, Bearden, Carrie E., Berk, Michael, Bohman, Hannes, Dandash, Orwa, Díaz‐Caneja, Covadonga M., Edbom, Carl T., Erp, Theo G. M., Fett, Anne‐Kathrin J., Frangou, Sophia, Goldstein, Benjamin I., Grigorian, Anahit, Jahanshad, Neda, James, Anthony C., Janssen, Joost, Johannessen, Cecilie, Karlsgodt, Katherine H., Kempton, Matthew J., Kochunov, Peter, Krabbendam, Lydia, Kyriakopoulos, Marinos, Lundberg, Mathias, MacIntosh, Bradley J., Rund, Bjørn Rishovd, Smelror, Runar E., Sultan, Alysha, Tamnes, Christian K., Thomopoulos, Sophia I., Vajdi, Ariana, Wedervang‐Resell, Kirsten, Myhre, Anne M., Andreassen, Ole A., Thompson, Paul M., and Agartz, Ingrid

Abstract

Early-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early-onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early-onset psychosis (mean age: 16.4 ± 1.4 years, mean illness duration: 1.5 ± 1.4 years, 39.2% female) and 359 healthy controls (mean age: 15.9 ± 1.7 years, 45.4% female) with magnetic resonance imaging data, pooled from 11 clinical cohorts. Patients were diagnosed with early-onset schizophrenia (n = 183), affective psychosis (n = 39), or other psychotic disorders (n = 41). We used linear mixed-effects models to investigate differences in intracranial and subcortical volumes across the patient sample, diagnostic subgroup and antipsychotic medication, relative to controls. We observed significantly lower intracranial (Cohen's d = −0.39) and hippocampal (d = −0.25) volumes, and higher caudate (d = 0.25) and pallidum (d = 0.24) volumes in patients relative to controls. Intracranial volume was lower in both early-onset schizophrenia (d = −0.34) and affective psychosis (d = −0.42), and early-onset schizophrenia showed lower hippocampal (d = −0.24) and higher pallidum (d = 0.29) volumes. Patients who were currently treated with antipsychotic medication (n = 193) had significantly lower intracranial volume (d = −0.42). The findings demonstrate a similar pattern of brain alterations in early-onset psychosis as previously reported in adult psychosis, but with notably low intracranial volume. The low intracranial volume suggests disrupted neurodevelopment in adolescent early-onset psychosis.

Published
2020
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3. Intracranial and subcortical volumes in adolescents with early-onset psychosis: A multisite mega-analysis from the ENIGMA consortium.

Author

Gurholt TP, Lonning V, Nerland S, Jørgensen KN, Haukvik UK, Alloza C, Arango C, Barth C, Bearden CE, Berk M, Bohman H, Dandash O, Díaz-Caneja CM, Edbom CT, van Erp TGM, Fett AJ, Frangou S, Goldstein BI, Grigorian A, Jahanshad N, James AC, Janssen J, Johannessen C, Karlsgodt KH, Kempton MJ, Kochunov P, Krabbendam L, Kyriakopoulos M, Lundberg M, MacIntosh BJ, Rund BR, Smelror RE, Sultan A, Tamnes CK, Thomopoulos SI, Vajdi A, Wedervang-Resell K, Myhre AM, Andreassen OA, Thompson PM, and Agartz I

Subjects
Adolescent, Affective Disorders, Psychotic diagnostic imaging, Age of Onset, Brain diagnostic imaging, Globus Pallidus diagnostic imaging, Globus Pallidus pathology, Hippocampus diagnostic imaging, Hippocampus pathology, Humans, Magnetic Resonance Imaging, Psychotic Disorders diagnostic imaging, Schizophrenia diagnostic imaging, Adolescent Development physiology, Affective Disorders, Psychotic pathology, Brain pathology, Psychotic Disorders pathology, Schizophrenia pathology
Abstract

Early-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early-onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early-onset psychosis (mean age: 16.4 ± 1.4 years, mean illness duration: 1.5 ± 1.4 years, 39.2% female) and 359 healthy controls (mean age: 15.9 ± 1.7 years, 45.4% female) with magnetic resonance imaging data, pooled from 11 clinical cohorts. Patients were diagnosed with early-onset schizophrenia (n = 183), affective psychosis (n = 39), or other psychotic disorders (n = 41). We used linear mixed-effects models to investigate differences in intracranial and subcortical volumes across the patient sample, diagnostic subgroup and antipsychotic medication, relative to controls. We observed significantly lower intracranial (Cohen's d = -0.39) and hippocampal (d = -0.25) volumes, and higher caudate (d = 0.25) and pallidum (d = 0.24) volumes in patients relative to controls. Intracranial volume was lower in both early-onset schizophrenia (d = -0.34) and affective psychosis (d = -0.42), and early-onset schizophrenia showed lower hippocampal (d = -0.24) and higher pallidum (d = 0.29) volumes. Patients who were currently treated with antipsychotic medication (n = 193) had significantly lower intracranial volume (d = -0.42). The findings demonstrate a similar pattern of brain alterations in early-onset psychosis as previously reported in adult psychosis, but with notably low intracranial volume. The low intracranial volume suggests disrupted neurodevelopment in adolescent early-onset psychosis., (© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)

Published
2022
Full Text
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