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The ability to locate and quantify large strains will significantly improve the real‐world application scenario of flexible and stretchable strain sensors. However, current methods for implementing stretchable distributed strain sensing still face challenges such as complicated demodulation, multisensor crosstalk, and high power consumption. Herein, a self‐powered and stretchable optical fiber strain sensor is reported with distributed sensing capability based on mechanoluminescent optical fiber, where mechanoluminescent phosphors with different emission color light are discretely integrated onto the outer cladding of the elastomer optical fiber. Based on the wavelength coding technique and time‐domain filtering comparison method, the capability of strain magnitude quantification (10–60%) and strain location identification together in a single stretchable optical fiber is successfully realized, even at multiple positions simultaneously in the strain‐applied situation. Moreover, this stretchable optical fiber strain sensor shows insensitivity to bending, compression, and temperature disturbances and outstanding durability (>8000 cycles). Due to the excellent light confinement of the elastomer optical fiber, demonstrations such as bright‐field measurement, saline water operation, and wearable glove application exhibit its potential as a promising technology for future self‐powered distributed optical sensing systems.

Flexible strain sensors are essential components of wearable smart devices that perceive and respond to strain stimulations. However, the sensitivity and response time of most sensors require further improvement to detect subtle strains related to human bodies. Herein, an ultrasensitive flexible optical sensor with fast response time has been built based on a microfiber coupler encapsulated in polydimethylsiloxane. Benefiting from dramatic change of coupling ratio of the microfiber coupler under weak strain, this flexible strain sensor exhibits ultrahigh strain sensitivity (gauge factor, GF = 900), low detection limit (0.001%), ultrafast response time (10 000 cycles). Real‐time capturing and recognizing of respiration, broadband sound signals, and pulse waves at different sites of human body have been demonstrated based on this highly sensitive microfiber coupler sensor. Moreover, simultaneous detection of the wrist pulse and human voice has been achieved based on the frequency division multiplexing technology. This flexible photonics strain sensor could serve as the prototype of ultrasensitive flexible optical sensors with fast response time for the development of high performance and wearable healthcare devices.

Abstract Sepsis, caused by uncontrollable infection and inflammatory response, leads to more than 30 million infected patients and results in high morbidity worldwide every year. Currently, no efficient approaches have been developed for sepsis therapy due to antimicrobial resistance and inflammatory storm. Here, we report macrophages loaded with aggregated carbon dots (ACDs) in the lysosome, termed MCDs, to treat sepsis in immunosuppressive mice. The ACDs are constructed by negative CDs and amine‐abundant polyethyleneimine (PEI), enabling them to bear the strong antibacterial ability and enhanced photoluminescent efficacy. The ACDs are specifically located in the macrophage lysosomes, efficiently enhancing the multidrug‐resistant bacteria‐killing ability of MCDs. More importantly, the MCDs possess superior anti‐inflammatory effects such as reducing the number of pro‐inflammatory (M1) and stimulating anti‐inflammatory (M2) macrophages. These effects upregulate the inflammatory cytokines (TNF‐α, IL‐1β, IL‐4, and IL‐10), ultimately resulting in increased sepsis survival. Our work provides an intelligent approach to overcoming multidrug‐resistant bacteria‐induced infection from sepsis patients and paves a new avenue on employing nanoparticle‐loaded cells for combating inflammation‐related infection.

Abstract Scintillators, which can convert high‐energy ionizing radiation into visible light, have been serving as the core component in radiation detectors for more than a century of history. To address the increasing application demands along with the concern on nuclear security, various strategies have been proposed to develop a next‐generation scintillator with a high performance in past decades, among which the novel approach via structure control has received great interest recently due to its high feasibility and efficiency. Herein, the concept of “structure engineering” is proposed for the exploration of this type of scintillators. Via internal or external structure design with size ranging from micro size to macro size, this promising strategy cannot only improve scintillator performance, typically radiation stopping power and light yield, but also extend its functionality for specific applications such as radiation imaging and therapy, opening up a new range of material candidates. The research and development of various types of structured scintillators are reviewed. The current state‐of‐the‐art progresses on structure design, fabrication techniques, and the corresponding applications are discussed. Furthermore, an outlook focusing on the current challenges and future development is proposed.

Strain sensors that can work sustainably and continuously without any external power supply are highly desirable for future wearable and implantable devices. Herein, a self‐powered stretchable strain sensor based on the integration of mechanoluminescent phosphors with an elastomer optical fiber is proposed and developed. This mechanoluminescent optical fiber is capable of emitting light just driven by external strain, without the need of an external light source or electric power. The strain‐induced emitted light can be collected and guided along the mechanoluminescent optical fiber. The sensor exhibits linear strain response up to 50% and high‐accuracy strain measurement (±1%). Moreover, this optical fiber strain sensor displays consistent signals over 10 000 stretch–release motion cycles, which demonstrates the good durability of the sensor. Due to the excellent light confinement of the elastomer optical fiber, this strain sensor is demonstrated in both bright‐ and dark‐field measurements, wearable gloves, and an implantable sensing device, thereby demonstrating potential as a promising technology for future self‐powered optical sensor systems.