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38 results on '"Zhang, Zhanjun"'

5. Medium Bandgap Small Molecule Acceptors With Isomer‐Free Chlorinated End Groups Enabling High‐Performance Tandem Organic Solar Cells

Author

Jia, Zhenrong, primary, Ma, Qing, additional, Meng, Lei, additional, Zhang, Jinyuan, additional, Qin, Shucheng, additional, Chen, Zeng, additional, Li, Xiaojun, additional, Zhang, Jianqi, additional, Li, Jing, additional, Zhang, Zhanjun, additional, Wei, Zhixiang, additional, Yang, Yang(Michael), additional, and Li, Yongfang, additional

Published
2022
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14. Effects of Short‐Axis Alkoxy Substituents on Molecular Self‐Assembly and Photovoltaic Performance of Indacenodithiophene‐Based Acceptors

Author

Li, Xiaojun, primary, Huang, He, additional, Angunawela, Indunil, additional, Zhou, Jiadong, additional, Du, Jiaqi, additional, Liebman‐Pelaez, Alex, additional, Zhu, Chenhui, additional, Zhang, Zhanjun, additional, Meng, Lei, additional, Xie, Zengqi, additional, Ade, Harald, additional, and Li, Yongfang, additional

Published
2019
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21. Gold Content of Mantle-Derived Rocks from Eastern China and Its Implications

Author

Zhang Zhanjun, He Ying, Yue Ke-fen, Dong Zhenxin, and Wang Xin

Subjects
Basalt, geography, geography.geographical_feature_category, Paleozoic, Volcano, Continental crust, Geochemistry, Geology, Xenolith, Quaternary, Kimberlite, Mantle (geology)
Abstract

We have analyzed the gold content of 65 samples of mantle-derived xenoliths and their host rocks from eastern China, which is found to be inhomogeneous, falling in the ranges of 1.0times10−9-8.2times10−9 (averaging 3.8 times 10-9) and 0.2times10−9-5.3times10−9 (averaging 2.7times10−9) in the mantle-derived xenoliths and the host basalts respectively. Except the samples from Wanquan County of Hebei Province and Anding County of Hainan Province, the gold content is the highest on the margins of the North China platform and decreases spatially towards the north and south, and temporally the samples of the Tertiary have a higher gold content than those of the Quaternary. The gold content of the mantle-derived xenoliths and the host Paleozoic kimberlites is 3.8times10−9-180times10−9 and 0.1times10−9-38.0times10−9 respectively, which are higher than that in the mantle-derived xenoliths in basalt and the host Cenozoic basalts. The mantle-derived xenoliths have a higher gold content than the host rocks, but their relativity is not very clear, suggesting that the genetic relationship between them is complex. Our data indicate that the average gold content of the lithospheric mantle in eastern China is approximately equal to or approaching 3.8times10−9, which is lower than the average abundance of the upper mantle (5.0times10−9), higher than the average abundance of the continental crust (3.0times10−9) and only slightly higher than the average abundance of the lower continental crust (3.4times10−9). Except the samples from Hainan Province, the mantle-derived xenoliths in basalts with a high gold content are distributed on the two margins of the North China platform, corresponding to the gold deposits-concentrated districts in northwest Hebei Province and Shandong Province, showing the control by the old continental lithospheric mantle and the lower continental crust on the margins of the North China platform. The gold content of the mantle-derived xenoliths from Hainan Province ranges from 7.1times10−9 to 15times10−9, suggesting that some blocks of the lithospheric mantle in Hainan Province may be derived from the ancient gold-rich lithospheric mantle of western Australia and that Hainan Province may possibly be an important gold deposits-concentrated district. Some mantle-derived xenoliths in kimberlite of Shandong Province have an excessively high gold content amounting to 180times10−9, which provides new evidence for the possibility of “finding gold deposits near kimberlite pipes or alkali-basalt volcanic vents”. Thererfore, the gold content of the mantle-derived xenoliths may be an indicator to the distribution of gold deposits-concentrated districts.

Published
2010

22. Isomeric Effects of Solution Processed Ladder‐Type Non‐Fullerene Electron Acceptors

Author

Li, Yongxi, primary, Zhong, Lian, additional, Lin, Jiu‐Dong, additional, Wu, Fu‐Peng, additional, Bin, Hai‐Jun, additional, Zhang, Zhanjun, additional, Xu, Lai, additional, Jiang, Zuo‐Quan, additional, Zhang, Zhi‐Guo, additional, Liu, Feng, additional, Russell, Thomas P., additional, Li, Yongfang, additional, Liao, Liang‐Sheng, additional, and Forrest, Stephen R., additional

Published
2017
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35. Tau as a biomarker of cognitive impairment and neuropsychiatric symptom in Alzheimer's disease.

Author

Dang M, Chen Q, Zhao X, Chen K, Li X, Zhang J, Lu J, Ai L, Chen Y, and Zhang Z

Subjects
Humans, Brain pathology, Positron-Emission Tomography methods, Biomarkers metabolism, tau Proteins metabolism, Amyloid beta-Peptides metabolism, Alzheimer Disease complications, Alzheimer Disease diagnostic imaging, Cognitive Dysfunction diagnostic imaging, Cognitive Dysfunction etiology
Abstract

The A/T/N research framework has been proposed for the diagnosis and prognosis of Alzheimer's disease (AD). However, the spatial distribution of ATN biomarkers and their relationship with cognitive impairment and neuropsychiatric symptoms (NPS) need further clarification in patients with AD. We scanned 83 AD patients and 38 cognitively normal controls who independently completed the mini-mental state examination and Neuropsychiatric Inventory scales. Tau, Aβ, and hypometabolism spatial patterns were characterized using Statistical Parametric Mapping together with [18F]flortaucipir, [18F]florbetapir, and [18F]FDG positron emission tomography. Piecewise linear regression, two-sample t-tests, and support vector machine algorithms were used to explore the relationship between tau, Aβ, and hypometabolism and cognition, NPS, and AD diagnosis. The results showed that regions with tau deposition are region-specific and mainly occurred in inferior temporal lobes in AD, which extensively overlaps with the hypometabolic regions. While the deposition regions of Aβ were unique and the regions affected by hypometabolism were widely distributed. Unlike Aβ, tau and hypometabolism build up monotonically with increasing cognitive impairment in the late stages of AD. In addition, NPS in AD were associated with tau deposition closely, followed by hypometabolism, but not with Aβ. Finally, hypometabolism and tau had higher accuracy in differentiating the AD patients from controls (accuracy = 0.88, accuracy = 0.85) than Aβ (accuracy = 0.81), and the combined three were the highest (accuracy = 0.95). These findings suggest tau pathology is superior over Aβ and glucose metabolism to identify cognitive impairment and NPS. Its results support tau accumulation can be used as a biomarker of clinical impairment in AD., (© 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)

Published
2023
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36. SORL1 rs1699102 polymorphism modulates age-related cognitive decline and gray matter volume reduction in non-demented individuals.

Author

Li H, Lv C, Yang C, Wei D, Chen K, Li S, and Zhang Z

Subjects
Aged, Aging, Alleles, Brain pathology, Cognitive Dysfunction diagnostic imaging, Cognitive Dysfunction pathology, Female, Genotype, Gray Matter pathology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Organ Size genetics, Brain diagnostic imaging, Cognition physiology, Cognitive Dysfunction genetics, Gray Matter diagnostic imaging, LDL-Receptor Related Proteins genetics, Membrane Transport Proteins genetics, Polymorphism, Single Nucleotide
Abstract

Background and Purpose: SORL1 rs1699102 is associated with the risk of late-onset Alzheimer's disease. However, the effects of this single nucleotide polymorphism on cognition and brain structure during normal aging are unclear. This study aimed to examine the effects of the rs1699102 polymorphism on age-related cognitive decline and cortical gray matter reduction in the Chinese Han population., Methods: A total of 780 non-demented adults completed a battery of neuropsychological tests. High-resolution T1-weighted structural magnetic resonance imaging data from 89 of these subjects were also collected using a Siemens Trio 3.0 Tesla scanner., Results: The T allele carriers displayed an accelerated age-related change in episodic memory and processing speed tests relative to the CC genotype. A similar pattern was observed in the age-related gray matter volume (GMV) reduction of the right middle temporal pole. The GMV in this region was significantly positively correlated with the episodic memory scores., Conclusions: The SORL1 gene rs1699102 polymorphism has been found to be associated with age-related cognitive decline and GMV reduction of the right middle temporal pole in older adults. These findings elucidate how the SORL1 variants shape the neural system to modulate age-related cognitive decline and support the hypothesis that SORL1 may represent a candidate gene for late-onset Alzheimer's disease., (© 2016 EAN.)

Published
2017
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37. Precuneus degeneration in nondemented elderly individuals with APOE ɛ4: Evidence from structural and functional MRI analyses.

Author

Chen Y, Liu Z, Zhang J, Chen K, Yao L, Li X, Gong G, Wang J, and Zhang Z

Subjects
Aged, Aged, 80 and over, Aging pathology, Brain Mapping, Female, Genotype, Humans, Image Processing, Computer-Assisted, Male, Memory, Episodic, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Oxygen blood, Apolipoprotein E4 genetics, Magnetic Resonance Imaging, Neurodegenerative Diseases diagnostic imaging, Neurodegenerative Diseases genetics, Neurodegenerative Diseases pathology, Parietal Lobe diagnostic imaging, Parietal Lobe pathology
Abstract

Neurodegenerative diseases such as Alzheimer's disease (AD) have been recognized to exhibit disease-specific brain vulnerability patterns. Apolipoprotein E (APOE) ɛ4 allele imparts a high genetic risk of developing AD. Whether the APOE ɛ4 allele damages the brain when cognitive functions are still intact is important to understand, especially for possible early detection and intervention. This study aimed to examine the selective degeneration pattern associated with the APOE ɛ4 allele in the brains of cognitively normal elderly subjects. We enrolled 35 cognitively healthy ɛ4 carriers and 40 non-carriers (53 to 81 years old) to evaluate group differences in cortical thickness and brain activation during a memory-encoding task. We also assessed the functional connectivity of the brain regions with both structural and functional damages. The results from the neuropsychological tests showed that the performances of ɛ4 carriers and non-carriers were comparable. Primarily, we found that the precuneus exhibited thinner cortical thickness and decreased deactivation during memory encoding. Furthermore, the connectivity analyses show that carriers exhibited damaged connectivity of the precuneus to several regions in the default mode network and the attention/executive control network. Our study reveals the degeneration pattern of the ɛ4 allele, which could be used as a potential biomarker for early detection for possible interventions and treatments. Hum Brain Mapp 38:271-282, 2017. © 2016 Wiley Periodicals, Inc., (© 2016 Wiley Periodicals, Inc.)

Published
2017
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38. Effects of APOE promoter polymorphism on the topological organization of brain structural connectome in nondemented elderly.

Author

Shu N, Li X, Ma C, Zhang J, Chen K, Liang Y, Chen Y, and Zhang Z

Subjects
Aged, Aged, 80 and over, Aging pathology, Asian People, Cognition physiology, DNA Mutational Analysis, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Models, Neurological, Neural Pathways, Neuropsychological Tests, Aging genetics, Apolipoproteins E genetics, Brain pathology, Brain Mapping, Polymorphism, Single Nucleotide genetics, Promoter Regions, Genetic genetics
Abstract

The polymorphism of the Apolipoprotein E (APOE) promoter rs405509 can regulate the transcriptional activity of the APOE gene and is related to Alzheimer's disease (AD). However, its effects on cognitive performance and the underlying brain mechanisms remain unknown. Here, we performed a battery of neuropsychological tests in a large sample (837 subjects) of nondemented elderly Chinese people, and explored the related brain mechanisms via the construction of diffusion MRI-based structural connectome and graph analysis from a subset (84 subjects) of the sample. Cognitively, the rs405509 risk allele (TT) carriers showed decreased attention and execution functions compared with noncarriers (GG/GT). Regarding the topological alterations of the brain connectome, the risk allele group exhibited reduced global and local efficiency of white matter structural networks, mainly in the left anterior and posterior cingulate cortices (PCC). Importantly, the efficiency of the left PCC is correlated with the impaired attention function and mediates the impacts of the rs405509 genotype on attention. These results demonstrated that the rs405509 polymorphism affects attention function in nondemented elderly people, possibly by modulating brain structural connectivity of the PCC. This polymorphism may help us to understand the neural mechanisms of cognitive aging and to serve as a potential marker assessing the risk of AD., (© 2015 Wiley Periodicals, Inc.)

Published
2015
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