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Your search keyword '"Zaorsky, Nicholas G."' showing total 18 results
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18 results on '"Zaorsky, Nicholas G."'

3. Pan‐cancer analysis of prognostic metastatic phenotypes

Author

Zaorsky, Nicholas G., primary, Wang, Xi, additional, Garrett, Sara M., additional, Lehrer, Eric J., additional, Lin, Christine, additional, DeGraff, David J., additional, Spratt, Daniel E., additional, Trifiletti, Daniel M., additional, Kishan, Amar U., additional, Showalter, Timothy N., additional, Park, Henry S., additional, Yang, Jonathan T., additional, Chinchilli, Vernon M., additional, and Wang, Ming, additional

Published
2021
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6. Long‐term causes of death among pediatric patients with cancer

Author

Horn, Samantha R., primary, Stoltzfus, Kelsey C., additional, Mackley, Heath B., additional, Lehrer, Eric J., additional, Zhou, Shouhao, additional, Dandekar, Smita C., additional, Fox, Edward J., additional, Rizk, Elias B., additional, Trifiletti, Daniel M., additional, Rao, Pooja M., additional, and Zaorsky, Nicholas G., additional

Published
2020
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9. Risk‐adapted stereotactic body radiation therapy for central and ultra‐central early‐stage inoperable non‐small cell lung cancer

Author

Meng, Mao‐Bin, primary, Wang, Huan‐Huan, additional, Zaorsky, Nicholas G., additional, Sun, Bing‐Shen, additional, Zhu, Lei, additional, Song, Yong‐Chun, additional, Li, Feng‐Tong, additional, Dong, Yang, additional, Wang, Jing‐Sheng, additional, Chen, Hua‐Ming, additional, Yu, Xu‐Yao, additional, and Yuan, Zhi‐Yong, additional

Published
2019
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18. Current treatment and future directions in the management of anal cancer.

Author

Tchelebi LT, Eng C, Messick CA, Hong TS, Ludmir EB, Kachnic LA, and Zaorsky NG

Subjects
Antineoplastic Combined Chemotherapy Protocols therapeutic use, Chemoradiotherapy methods, Fluorouracil therapeutic use, Humans, Anus Neoplasms drug therapy, Anus Neoplasms pathology, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell therapy, Radiotherapy, Intensity-Modulated methods
Abstract

Although rare, the rate of squamous cell carcinoma of the anus (SCCA) is rising globally. Most patients present with nonmetastatic disease and are curable with appropriate treatment, which has evolved significantly over the last several decades. Before the 1970s, SCCA was managed with radical surgery, resulting in a permanent colostomy. Researchers found that preoperative treatment with chemotherapy and concurrent radiation could achieve a pathologic complete response. After this observation, definitive therapy shifted from radical surgery to sphincter-preserving chemoradiation. Investigations into the necessity of chemotherapy and the optimal regimen found that chemotherapy with mitomycin-C and 5-fluorouracil is required for cure. Further studies evaluating the addition of induction or maintenance chemotherapy, monoclonal antibody therapy, or higher radiation doses have demonstrated no significant benefit to disease control. Advanced radiation delivery with intensity-modulated radiotherapy techniques is now considered the standard of care because of its prospectively determined, favorable acute toxicity profile compared with 3-dimensional conformal radiation. It is important to note that chemoradiation treatment response may be slow (up to 26 weeks) and should be assessed through serial clinical examinations. Today, surgical management of SCCA is reserved only for the lowest risk, early stage tumors or for recurrent/persistent disease. Current studies are evaluating radiation dose de-escalation in early stage disease and radiation dose escalation and the addition of immune checkpoint inhibitors in locally advanced cancers. In reviewing how and why modern-day treatment of SCCA was established, the objective of this report is to reenforce adherence to current treatment paradigms to assure the best possible outcomes for patients., (© 2021 The Authors. CA: A Cancer Journal for Clinicians published by Wiley Periodicals LLC on behalf of American Cancer Society.)

Published
2022
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