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Your search keyword '"ZHOU Xinyao"' showing total 14 results
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14 results on '"ZHOU Xinyao"'

3. Dynamics of T follicular helper cells in patients with rheumatic diseases and subsequent antibody responses in a three‐dose immunization regimen of CoronaVac

Author

Zhou, Xingyu, primary, Wang, Yifan, additional, Huang, Bo, additional, Feng, Ruiling, additional, Zhou, Xinyao, additional, Li, Chun, additional, Zhang, Xia, additional, Shao, Miao, additional, Gan, Yuzhou, additional, Jin, Yuebo, additional, An, Yuan, additional, Xiao, Xian, additional, Wang, Shiyang, additional, Liu, Qinghong, additional, Cheng, Gong, additional, Zhu, Fengyunzhi, additional, Zhang, Kai, additional, Wang, Naidi, additional, Xing, Xiaoyan, additional, Li, Ru, additional, Li, Yuhui, additional, Liu, Yisi, additional, Lu, Dan, additional, Sun, Xiaolin, additional, Li, Zhanguo, additional, Liu, Yudong, additional, and He, Jing, additional

Published
2022
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13. Noninvasive detection of twin zygosity using genome-wide linkage disequilibrium information.

Author

Kong L, Yang Y, Yuan C, Wei X, Zhou X, Zhou J, Xing Y, Zou G, Sun Q, Cai L, Liang Q, Zhang Y, Wang H, Liu Z, Wu D, and Sun L

Subjects
Humans, Female, Pregnancy, Polymorphism, Single Nucleotide genetics, Twins, Monozygotic genetics, Linkage Disequilibrium genetics
Abstract

Dear Editor, in this study, we propose a novel linkage disequilibrium information-based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus-specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost-effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies., (© 2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.)

Published
2024
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14. Prenatal Diagnosed Agenesis of the Corpus Callosum: Identifying the Underlying Genetic Etiologies.

Author

Wei X, Cai L, Zhang L, Chen J, Zhang Y, Meng M, Yang Y, Zhou X, Zou G, and Sun L

Subjects
Humans, Female, Pregnancy, Retrospective Studies, Adult, Prenatal Diagnosis methods, Karyotyping, DNA Copy Number Variations, Pregnancy Outcome, Amniocentesis, Exome Sequencing, Agenesis of Corpus Callosum genetics, Agenesis of Corpus Callosum diagnosis, Agenesis of Corpus Callosum diagnostic imaging
Abstract

Objective: To assess the genetic etiologies underlying agenesis of the corpus callosum (ACC) and its pregnancy outcomes in the era of next-generation sequencing., Methods: A retrospective analysis was conducted on prospectively collected prenatal ACC cases in which amniocentesis was performed between January 2016 and December 2022. ACC was divided into non-isolated and isolated according to the presence or absence of ultrasound abnormalities. Chromosomal microarray analysis (CMA), karyotyping and exome sequencing (ES) were performed after genetic counseling. Pregnancy outcomes were assessed by pediatric neurosurgeons and were followed up by telephone through their parents., Results: Sixty-eight fetuses with ACC were enrolled in this study. CMA detected eight cases with pathogenic copy number variants (CNVs) and all were non-isolated ACC, with a detection rate of 11.8% (8/68). Among the CMA abnormalities, the majority (6/8) were detectable by karyotyping. ES was performed in 26 cases with normal CMA, revealing pathogenic or likely pathogenic gene variations in 12 cases (46.2%, 12/26), involving L1CMA, SMARCB1, PPP2R1A, ARID1B, USP34, CDC42, NFIA and DCC genes. The detection rates of ES in isolated and non-isolated ACC were 40% (6/15) and 54.5% (6/11), respectively. After excluding cases where pregnancy was terminated (56 cases), there were 12 live births, ranging in age from 15 months to 7 years. Of these, 91.7% (11 out of 12) demonstrated normal neurodevelopmental outcomes. Specifically, all five cases with isolated ACC and negative ES results exhibited normal neurodevelopment. The remaining six cases with favorable outcomes were all isolated ACC, among which ES identified variants of DCC and USP34 gene in one each case. The other four cases were CMA-negative and declined ES., Conclusions: We highlight the efficacy of prenatal ES in determining the genetic etiology of ACC, whether isolated or not. Favorable neurodevelopmental outcomes were observed when ACC was isolated and with normal ES results., (© 2024 John Wiley & Sons Ltd.)

Published
2024
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