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A direct one-pot method for the synthesis of isoxazoles from enaminones (I) is described through their PIDA-promoted cyclization to azirines followed by a previously reported FeCl2-catalyzed rearrangement.

A group of functionalized oxazoles were synthesized in moderate to good yields from enamides via phenyliodine diacetate (PIDA)-mediated intramolecular cyclization. The main advantageous features of the present method include its broad substrate scope and the heavy-metal-free characteristic of the oxidative carbon–oxygen bond formation process.