8 results on '"Yung-Tai Chen"'
Search Results
2. Long‐Term Risk of Cardiovascular Events in Patients With Chronic Kidney Disease Who Have Survived Sepsis: A Nationwide Cohort Study
- Author
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Chia‐Jen Shih, Pei‐Wen Chao, Shuo‐Ming Ou, and Yung‐Tai Chen
- Subjects
cardiovascular events ,chronic kidney disease ,epidemiology ,infection ,sepsis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundLong‐term cardiovascular outcomes after sepsis in patients with chronic kidney disease are not well known. We aimed to examine the risk of subsequent cardiovascular events in patients with chronic kidney disease discharged after hospitalization for sepsis in Taiwan. Methods and ResultsUsing complete claims data for patients with chronic kidney disease from Taiwan's National Health Insurance Research Database, we identified patients with sepsis who survived hospitalization between 2000 and 2010. Each sepsis survivor was propensity score–matched to one nonsepsis hospitalized control patient. Cox regression models were used to estimate the hazard ratios (HRs) of clinical outcomes, including major adverse cardiovascular events (myocardial infarction and ischemic stroke), hospitalization for heart failure, and all‐cause death. Among 66 961 sepsis survivors, the incidence rates of all‐cause mortality and major adverse cardiovascular events during the study period were 288.51 and 47.05 per 1000 person‐years, respectively. In comparison with matched hospitalized nonsepsis control patients, sepsis survivors had greater risks of major adverse cardiovascular events (HR, 1.42; 95% CI, 1.37–1.47), myocardial infarction (HR, 1.39; 95% CI, 1.32–1.47), ischemic stroke (HR, 1.46; 95% CI, 1.40–1.52), hospitalization for heart failure (HR, 1.55; 95% CI, 1.51–1.59), and all‐cause mortality (HR, 1.56; 95% CI, 1.54–1.58). The results remained unchanged in analyses of several subgroups of patients, and were similar in analyses accounting for the competing risk of death. ConclusionsOur findings highlight the association of sepsis with a significantly increased long‐term risk of cardiovascular events among survivors in the chronic kidney disease population.
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- 2017
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3. The advantages of peritoneal dialysis over hemodialysis during the COVID‐19 pandemic
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Tz Heng Chen, Chih Ching Lin, Yu Hua Wen, Ann Charis Tan, Chun Fan Chen, Fan Yu Chen, and Yung Tai Chen
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Infection Control ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,SARS-CoV-2 ,business.industry ,medicine.medical_treatment ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,COVID-19 ,Hemodialysis, Home ,Peritoneal dialysis ,Renal Dialysis ,Nephrology ,Pandemic ,Disease Transmission, Infectious ,Commentary ,medicine ,Humans ,Kidney Failure, Chronic ,Hemodialysis ,business ,Intensive care medicine ,Pandemics ,Peritoneal Dialysis ,Disease transmission - Published
- 2020
- Full Text
- View/download PDF
4. Association of sleep apnoea with chronic kidney disease in a large cohort from Taiwan
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Yuan-Hao Lo, Yung Tai Chen, Hsi Chu, Shuo-Ming Ou, Kun Ta Chou, and Chia-Jen Shih
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,Hazard ratio ,Retrospective cohort study ,030204 cardiovascular system & hematology ,medicine.disease ,Confidence interval ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,Epidemiology ,Cohort ,medicine ,Physical therapy ,030212 general & internal medicine ,business ,Kidney disease - Abstract
Background and objective Recent observational studies have shown that sleep apnoea (SA) is associated with increased risk of incident CKD. However, the contribution of SA relative to common traditional CKD risk factors remains unknown. The aims of this study were to investigate the long-term risk of incident CKD events following SA diagnosis and compare the relative contributions of SA, diabetes and hypertension. Methods Data were retrieved from Taiwan's National Health Insurance Research Database during the period between 2000 and 2010 for this retrospective cohort study. The cohorts are composed of patients (age ≥ 20 years) newly diagnosed with SA and matched subjects without SA. The two cohorts were followed until the occurrence of CKD, death or the end of 2010. Results The sample is composed of 43 434 individuals (8687 patients with SA and 34 747 matched non-SA subjects). A total of 157 new CKD events in patients with SA and 298 events in the matched non-SA cohort were recorded during a mean follow-up period of 3.9 years (incidence rates, 4.5 and 2.2/per 1000 person-years). The risk of CKD development was greater among patients with SA than in the matched non-SA cohort (adjusted hazard ratio (aHR) 1.58, 95% confidence interval ( CI): 1.29–1.94). The contribution of SA to the CKD hazard was similar to that of hypertension (aHR 1.17, 95% CI: 0.68–2.01, P = 0.56), whereas that of diabetes remained significantly higher (aHR 2.17, 95% CI: 1.21–3.90, P = 0.01). Conclusion SA was associated with an increase in the risk of CKD incidence similar to that of hypertension. See Editorial, page 578
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- 2016
5. Association of estimated glomerular filtration rate with all-cause and cardiovascular mortality: the role of malnutrition-inflammation-cachexia syndrome
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Chi Hung Lin, Chia-Jen Shih, Chih-Kang Chiang, Der-Cherng Tarng, Shuo-Ming Ou, Szu-Chun Hung, and Yung Tai Chen
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medicine.medical_specialty ,business.industry ,Hazard ratio ,030232 urology & nephrology ,Renal function ,030204 cardiovascular system & hematology ,medicine.disease ,Gastroenterology ,Confidence interval ,Cachexia ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Physiology (medical) ,Internal medicine ,Sarcopenia ,medicine ,Orthopedics and Sports Medicine ,business ,Body mass index ,Cohort study ,Kidney disease - Abstract
Background Previous studies have demonstrated that high estimated glomerular filtration rate (eGFR) is paradoxically associated with an increased risk of mortality, and the association becomes more predominant in older people. However, the role of malnutrition–inflammation–cachexia syndrome (MICS) in the association between eGFR and mortality has never been explored. Methods We conducted a community-based cohort study using data from the Taipei City Elderly Health Examination Database, collected during the period 2001–10. All participants aged ≥65 years were included and stratified by the absence or presence of MICS, which is defined as the presence of at least one of the following markers: body mass index
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- 2016
6. Risk and impact of tuberculosis in patients with chronic myeloid leukemia: A nationwide population-based study in Taiwan
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Chia Jen Liu, Jyh Pyng Gau, Ying Chung Hong, Chung Jen Teng, Yu Wen Hu, Fan Chen Ku, Tzeng Ji Chen, Cheng Hwai Tzeng, Chiu Mei Yeh, Yung Tai Chen, Sheng Hsuan Chien, Tzeon Jye Chiou, and Man Hsin Hung
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Cancer Research ,medicine.medical_specialty ,Tuberculosis ,business.industry ,Proportional hazards model ,medicine.medical_treatment ,Mortality rate ,Incidence (epidemiology) ,Hazard ratio ,Hematopoietic stem cell transplantation ,medicine.disease ,Transplantation ,Oncology ,hemic and lymphatic diseases ,Internal medicine ,Cohort ,Immunology ,medicine ,business - Abstract
The relationship between chronic myeloid leukemia (CML) and tuberculosis (TB) has not been determined. We conducted a national survey including 1,082 CML patients identified from the Taiwan National Health Insurance database covering a period between 1998 and 2011; the matched non-exposed cohort included 10,820 subjects without CML that were matched for age, sex and comorbidities. The impact of TB was measured by the overall mortality, and the risk factors were identified by a multivariate Cox proportional hazards model. We found the risk of TB was higher in the CML cohort, with an adjusted hazard ratio (aHR) of 3.76 (p = 0.001) for both pulmonary (aHR 3.23, p
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- 2014
7. Pyogenic liver abscess in end-stage renal disease patients: A nationwide longitudinal study
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Tzen Wen Chen, Chien-Tsai Liu, Lung Wen Tsai, Chia Jen Shih, Shuo Ming Ou, Tzeng Ji Chen, Pei Wen Chao, Yung Tai Chen, and Szu Yuan Li
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Pyogenic liver abscess ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Mortality rate ,Incidence (epidemiology) ,Hazard ratio ,Hematology ,respiratory system ,urologic and male genital diseases ,medicine.disease ,female genital diseases and pregnancy complications ,End stage renal disease ,Surgery ,stomatognathic system ,Nephrology ,Internal medicine ,Cohort ,medicine ,lipids (amino acids, peptides, and proteins) ,Renal replacement therapy ,Hemodialysis ,business - Abstract
End-stage renal disease (ESRD) patients are more prone to infectious disease because of their immunocompromised status. However, the association between pyogenic liver abscess (PLA) and ESRD remains not clear. The aim of our study is to evaluate the incidence, risk factors, and outcomes of PLA in ESRD patients. We recruited all incident ESRD patients from the Taiwan National Health Insurance database from 1998 to 2006. The incidence rate of PLA in ESRD patients was compared with that of a randomly selected non-ESRD control group matched for age, sex gender, Charlson comorbidity score, diabetes mellitus, and cirrhosis. Among the 57,761 incident dialysis patients, there were 538 cases of PLA. The incidence rate of PLA was 18.20 per 10,000 person-years in the ESRD cohort and 6.34 per 10,000 person-years in matched control cohort. The rate of PLA was significantly higher in the ESRD cohort (hazard ratio 3.63, 95% confidence interval 2.83–4.65, P
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- 2014
8. Second primary cancers in patients with hepatocellular carcinoma: a nationwide cohort study in Taiwan
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Tzeng Ji Chen, Szu Yuan Li, Chien Wei Su, Chian Yaw Hwang, Wen Chieh Wu, Chia Jen Liu, Han-Chieh Lin, Wei Yu Kao, Jaw Ching Wu, Yee Chao, and Yung Tai Chen
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Male ,Oncology ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,animal structures ,Population ,Taiwan ,Comorbidity ,Risk Assessment ,Cohort Studies ,Sex Factors ,Risk Factors ,Internal medicine ,medicine ,Humans ,Registries ,Renal Insufficiency, Chronic ,education ,Aged ,Proportional Hazards Models ,education.field_of_study ,Urinary bladder ,Hepatology ,business.industry ,Incidence ,Incidence (epidemiology) ,Liver Neoplasms ,fungi ,Age Factors ,Cancer ,Neoplasms, Second Primary ,Middle Aged ,medicine.disease ,digestive system diseases ,medicine.anatomical_structure ,Biliary tract ,Hepatocellular carcinoma ,Multivariate Analysis ,Female ,business ,Kidney disease ,Cohort study - Abstract
Background There has been no large-scale population-based study on the incidence and clinical manifestations of second primary cancer (SPC) after diagnosis of hepatocellular carcinoma (HCC). Aims This study aimed to evaluate the incidence and the risk factors of SPC following HCC diagnosis. Method This study used data from the National Health Insurance Research Database of Taiwan to identify all HCC patients from 1 January 1997 to 31 December 2006. Cases of SPC were gathered using the ICD9-CM codes of 140–208.91. Standardized incidence ratios (SIRs) were conducted for incidence of SPC in HCC survivors. Competing-risks regression with adjustment of death was used to analyse the risk factors of SPC. Results From 45 976 HCC patients, 749 (1.6%) developed SPC after 90 days of HCC diagnosis. Male HCC patients had higher risks of gastric, biliary, urinary bladder, kidney and haematological cancers compared to the general male population. Female patients had higher incidences of biliary tract, kidney and bone and soft tissue cancers. Older age and chronic kidney disease (CKD) were independent factors predicting SPC. Conclusions SPC in patients with HCC is not rare in Taiwan. Urinary bladder cancer and renal cancer are more specific SPC for HCC patients. Better surveillance strategies for SPC should be established for HCC survivors, especially in the elderly or those with CKD.
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- 2013
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