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Your search keyword '"Yuichiro Hirayama"' showing total 5 results
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5 results on '"Yuichiro Hirayama"'

1. Fluorescent Aplyronine A: Intracellular Accumulation and Disassembly of Actin Cytoskeleton in Tumor Cells

Author

Yuki Saito, Yoshihiro Miwa, Hideo Kigoshi, Maho Morita, Kozo Yoneda, Yuka Sugiyama, Yuichiro Hirayama, Kota Yamagishi, Osamu Ohno, Masaki Kita, and Kiyotake Suenaga

Subjects
Cell Survival, Arp2/3 complex, Antineoplastic Agents, Apoptosis, Tumor cells, Biochemistry, Inhibitory Concentration 50, Mice, Cell Line, Tumor, Neoplasms, Aplysia, Animals, Humans, Biotinylation, Molecular Biology, Fluorescent Dyes, biology, Rhodamines, Chemistry, Organic Chemistry, Actin remodeling, Biological Transport, Actin cytoskeleton, Fluorescence, Actins, Cell biology, Actin Cytoskeleton, Aplyronine A, Microscopy, Fluorescence, biology.protein, Molecular Medicine, Macrolides, Intracellular
Published
2012
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2. Development of Highly Cytotoxic and Actin-Depolymerizing Biotin Derivatives of Aplyronine A

Author

Yuichiro Hirayama, Masaki Kita, Hideo Kigoshi, and Miyuki Sugiyama

Subjects
Models, Molecular, Cell Survival, Molecular Conformation, Biotin, macromolecular substances, Crystallography, X-Ray, Catalysis, Structure-Activity Relationship, chemistry.chemical_compound, PEG ratio, Humans, Structure–activity relationship, Cytotoxicity, Actin, Dose-Response Relationship, Drug, technology, industry, and agriculture, General Chemistry, General Medicine, Actins, chemistry, Biochemistry, Macrolides, Molecular probe, Linker, Ethylene glycol, HeLa Cells
Abstract

Tied up: a PEG-linked biotin derivative of marine macrolide aplyronine A (ApA) is shown to exhibit potent cytotoxicity and cause actin disassembly in tumor cells. This method of introducing a PEG linker at the end of the aliphatic tail should offer perspectives for developing and using versatile actin-targeting molecular probes. PEG=poly(ethylene glycol).

Published
2011
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3. Inside Cover: Fluorescent Aplyronine A: Intracellular Accumulation and Disassembly of Actin Cytoskeleton in Tumor Cells ChemBioChem 12/2012)

Author

Maho Morita, Kota Yamagishi, Yoshihiro Miwa, Yuka Sugiyama, Yuki Saito, Yuichiro Hirayama, Hideo Kigoshi, Masaki Kita, Kiyotake Suenaga, Osamu Ohno, and Kozo Yoneda

Subjects
biology, Chemistry, Organic Chemistry, Arp2/3 complex, Tumor cells, Actin cytoskeleton, Biochemistry, Fluorescence, Cell biology, Aplyronine A, Apoptosis, biology.protein, Molecular Medicine, Cover (algebra), Molecular Biology, Intracellular
Published
2012
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