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4 results on '"Yixue Gu"'

1. An autoantibody profile identified by human genome‐wide protein arrays in rheumatoid arthritis

Author

Xu Liu, Xiaoying Zhang, Yu‐Jian Kang, Fei Huang, Shuang Liu, Yixue Guo, Yingni Li, Changcheng Yin, Mingling Liu, Qimao Han, Qingwen Wang, Hua Ye, Haihong Yao, Chun Li, Jiahe Li, Wangzha Pingcuo, Yan Zhang, Yin Su, Ge Gao, Zhanguo Li, and Xiaolin Sun

Subjects
anticitrullination protein antibody (ACPA), autoantibody, HuProt array, rheumatoid arthritis, Medicine
Abstract

Abstract Precise diagnostic biomarkers of anticitrullination protein antibody (ACPA)‐negative and early‐stage RA are still to be improved. We aimed to screen autoantibodies in ACPA‐negative patients and evaluated their diagnostic performance. The human genome‐wide protein arrays (HuProt arrays) were used to define specific autoantibodies from the sera of 182 RA patients and 261 disease and healthy controls. Statistical analysis was performed with SPSS 17.0. In Phase I study, 51 out of 19,275 recombinant proteins covering the whole human genome were selected. In Phase II validation study, anti‐ANAPC15 (anaphase promoting complex subunit 15) exhibited 41.8% sensitivity and 91.5% specificity among total RA patients. There were five autoantibodies increased in ACPA‐negative RA, including anti‐ANAPC15, anti‐LSP1, anti‐APBB1, anti‐parathymosin, and anti‐UBL7. Anti‐parathymosin showed the highest prevalence of 46.2% (p = 0.016) in ACPA‐negative early stage (

Published
2024
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2. Cloning and functional characterization of TCRP1, a novel gene mediating resistance to cisplatin in an oral squamous cell carcinoma cell line

Author

Shasha Fan, Yixue Gu, Guopei Zheng, Yongmei Ouyang, Yanhui Yu, Bo Peng, Zhimin He, and Yan Xiong

Subjects
Cytoplasm, Cell Survival, Blotting, Western, Biophysics, Antineoplastic Agents, Apoptosis, Biology, Molecular cloning, Biochemistry, Gene cloning, Structural Biology, Cell Line, Tumor, TCRP1, Genetics, medicine, Humans, Cloning, Molecular, Molecular Biology, Gene, Cell Proliferation, Cisplatin, Cloning, Messenger RNA, Reverse Transcriptase Polymerase Chain Reaction, Microarray analysis techniques, Proteins, DNA, Neoplasm, Cell Biology, Flow Cytometry, Molecular biology, Drug Resistance, Multiple, Tongue Neoplasms, Gene Expression Regulation, Neoplastic, Microscopy, Fluorescence, Drug Resistance, Neoplasm, Cell culture, Carcinoma, Squamous Cell, RNA Interference, OSCC, Comet Assay, DNA Damage, medicine.drug
Abstract

To explore the mechanisms of chemotherapy resistance, we previously established a multi-drug resistant cell line, Tca8113/Pingyangmycin (Tca8113/PYM) and identified differential expression in known genes and ESTs using microarray analysis. From among those ESTs we have now identified a novel gene producing an mRNA of 1834 nucleotides translated into a protein having 235 amino acids. This gene was denominated as tongue cancer resistance-associated protein 1 gene (TCRP1, accession number: EF363480). We further determined its functional characteristics. The results demonstrate that TCRP1 mediates a specific resistance to cisplatin in Tca8113 cells by reducing the cisplatin-induced apoptosis. This suggests that TCRP1 might be a novel molecular target to develop agents to reverse cisplatin-induced chemoresistance.

Published
2011

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