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Abstract Aims Growing clinical evidence suggests that not all patients with rheumatoid arthritis (RA) benefit to the same extent by treatment with tripterygium glycoside (TG), which highlights the need to identify RA‐related genes that can be used to predict drug responses. In addition, single genes as markers of RA are not sufficiently accurate for use as predictors. Therefore, there is a need to identify paired expression genes that can serve as biomarkers for predicting the therapeutic effects of TG tablets in RA. Methods A total of 17 pairs of co‐expressed genes were identified as candidates for predicting an RA patient's response to TG therapy, and genes involved in the Lnc‐ENST00000602558/GF1 axis were selected for that purpose. A partial‐least‐squares (PLS)‐based model was constructed based on the expression levels of Lnc‐ENST00000602558/IGF1 in peripheral blood. The model showed high efficiency for predicting an RA patient's response to TG tablets. Results Our data confirmed that genes co‐expressed in the Lnc‐ENST00000602558/IGF1 axis mediate the efficacy of TG in RA treatment, reduce tumor necrosis factor‐α induced IGF1 expression, and decrease the inflammatory response of MH7a cells. Conclusion We found that genes expressed in the Lnc‐ENST00000602558/IGF1 axis may be useful for identifying RA patients who will not respond to TG treatment. Our findings provide a rationale for the individualized treatment of RA in clinical settings.

Objective To improve the treatment of the acetabular transverse posterior wall fracture (ATPWF), a novel anatomical locking guidance plate (NALGP) was designed and compared with traditional fixations using finite element analysis. Methods The ATPWF model was constructed using the three‐dimensional finite element model of the half pelvis via the Mimics software and three internal devices were used to fix this model: the posterior‐column locking plate with anterior‐column screws (PCLP), double‐column locking plates (DCLP), and NALGP. Next, mesh division was conducted by solid 187 tetrahedral elements in the workbench software. After defining the boundary condition and material properties, each assembly model was loaded in an increasing manner with a downward vertical force of 200, 400, and 600 N, respectively. The loading force was directed at 45 degrees upward in the coronal plane and 25 degrees backward in the sagittal plane. Finally, the stress distribution and stress peak of plates and screws were measured and evaluated, and the displacement of fracture fragments under different loading force was assessed among the three groups. Results For stress distribution, it was found that the stress mainly acted on the posterior‐column plate, especially concentrated at the middle and lower section of the plate in all three groups after fixation on the ATPWF. In addition, most stresses of screws appeared on the lag screws instead of the common screws. The common screws in the NALGP group experienced larger stresses under all loading force, while those in the DCLP group withstood less stresses compared to those in the PCLP group. For the displacement of fracture fragments, the NALGP group were found to have less fracture fragment displacements than the PCLP group, but had comparable results to DCLP at both the transverse fracture and the posterior wall fracture sites. Conclusion The newly‐designed fixation device showed superiorities on fracture stabilization over PCLP, but had comparable stability to DCLP. This suggests that the DCLP might be unnecessary for treating ATPWF in some instances because it might cause bigger surgical trauma and blood loss.

Abstract As a clean and renewable energy, wave energy has abundant reserves, and its reasonable development and utilization can effectively alleviate the problems of energy shortage and environmental pollution. This paper proposes a mechanical rectification wave energy converter. The reciprocating linear motion of the buoy is directly converted into the rotary motion through the ball screw. The magnetic coupling force transmission system is adopted to ensure the sealing of the device. Using mechanical rectification mechanism to ensure the service life of the generator. In addition, a dynamic model of the mechanical rectification wave energy converter is established. Through simulation analysis, the curve of power with load resistance is obtained. And there is an optimal load resistance value corresponding to the maximum power in different wave conditions. In order to improve the power generation efficiency, the maximum power point tracking control algorithm is designed based on the admittance differentiation method. By controlling the duty cycle of the switch tube in the Buck‐Boost chopper circuit, the variable load is realized, and then the maximum power point tracking control is realized. Finally, simulation analysis verifies the feasibility of the algorithm under different wave conditions.