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Your search keyword '"Yang, Hye-Jeong"' showing total 17 results
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17 results on '"Yang, Hye-Jeong"'

6. Euphorbiasteroid, a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3‐L1 cells via activation of AMP‐activated protein kinase

Author

Park, Su‐Jin, primary, Park, Jae Ho, additional, Han, Anna, additional, Davaatseren, Munkhtugs, additional, Kim, Hyun Jin, additional, Kim, Myung‐Sunny, additional, Hur, Haeng Jeon, additional, Sung, Mi‐Jeong, additional, Hwang, Jin‐Taek, additional, Yang, Hye Jeong, additional, and Kwon, Dae Young, additional

Published
2015
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12. Decursin, an Active Compound Isolated from Angelica gigas, Inhibits Fat Accumulation, Reduces Adipocytokine Secretion and Improves Glucose Tolerance in Mice Fed a High-Fat Diet

Author

Hwang, Jin-Taek, primary, Kim, Sung Hee, additional, Hur, Haeng Jeon, additional, Kim, Hyun Jin, additional, Park, Jae Ho, additional, Sung, Mi Jeong, additional, Yang, Hye Jeong, additional, Ryu, Shi Yong, additional, Kim, Young Sup, additional, Cha, Mi Ran, additional, Kim, Myung Sunny, additional, and Kwon, Dae Young, additional

Published
2011
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17. Decursin, an active compound isolated from Angelica gigas, inhibits fat accumulation, reduces adipocytokine secretion and improves glucose tolerance in mice fed a high-fat diet.

Author

Hwang JT, Kim SH, Hur HJ, Kim HJ, Park JH, Sung MJ, Yang HJ, Ryu SY, Kim YS, Cha MR, Kim MS, and Kwon DY

Subjects
3T3-L1 Cells, Adipokines antagonists & inhibitors, Adipokines metabolism, Animals, Anti-Obesity Agents chemistry, Anti-Obesity Agents isolation & purification, Benzopyrans chemistry, Benzopyrans isolation & purification, Blood Glucose metabolism, Body Weight drug effects, Butyrates chemistry, Butyrates isolation & purification, Cholesterol analysis, Diet, High-Fat adverse effects, Glucose Tolerance Test, Hypoglycemic Agents chemistry, Hypoglycemic Agents isolation & purification, Insulin Resistance, Liver metabolism, Male, Mice, Mice, Inbred C57BL, Obesity chemically induced, Obesity physiopathology, Weight Gain drug effects, Adipokines blood, Adipose Tissue metabolism, Angelica chemistry, Anti-Obesity Agents pharmacology, Benzopyrans pharmacology, Butyrates pharmacology, Hypoglycemic Agents pharmacology
Abstract

Decursin (De), an active component of Angelica gigas, is known to exert anticancer and neuroprotective effects. However, its antiobesity and antidiabetic potential has not yet been investigated. This study evaluated the antiobesity effect of decursin, particularly focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. Decursin treatment resulted in the inhibition of adipocyte differentiation and the expression of fatty acid synthase. The study further investigated these antiobesity effects using mice fed a normal diet (ND), a high-fat diet (HFD) and a HFD plus decursin 200 mg/kg diet (HFD + De) for 7 weeks. Mice administered HFD plus decursin showed a drastic decrease in weight gain, triglyceride content, total cholesterol content and fat size compared with those that received the HFD alone; this was observed despite similar quantities of total food intake. Furthermore, decursin improved glucose tolerance in mice fed a HFD. Finally, administration of decursin along with the HFD significantly reduced the secretion of HFD-induced adipocytokines such as leptin, resistin, IL-6 and MCP-1. These results suggest that decursin might be useful for the treatment of obesity and diabetes., (Copyright © 2011 John Wiley & Sons, Ltd.)

Published
2012
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