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Your search keyword '"Xu, Shuying"' showing total 14 results
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14 results on '"Xu, Shuying"'

2. Study of the effect of different functionalized magnesium hydroxide prepared by mechanochemical method on the flame retardancy and mechanical properties of styrene‐ethylene‐butadiene‐styrene/polypropylene composites

Author

Wang, Jingming, primary, Wang, Xiaoyang, additional, Chu, Zhen, additional, Liu, Jia, additional, Long, Shijie, additional, Xu, Shuying, additional, Wang, Dun, additional, Wang, Jieqiong, additional, and Liu, Zhongxin, additional

Published
2022
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5. CD82 controls CpG‐dependent TLR9 signaling

Author

Khan, Nida S., primary, Lukason, Daniel P., additional, Feliu, Marianela, additional, Ward, Rebecca A., additional, Lord, Allison K., additional, Reedy, Jennifer L., additional, Ramirez‐Ortiz, Zaida G., additional, Tam, Jenny M., additional, Kasperkovitz, Pia V., additional, Negoro, Paige E., additional, Vyas, Tammy D., additional, Xu, Shuying, additional, Brinkmann, Melanie M., additional, Acharaya, idu, additional, Artavanis‐Tsakonas, Katerina, additional, Frickel, Eva‐Maria, additional, Becker, Christine E., additional, Dagher, Zeina, additional, Kim, You‐Me, additional, Latz, Eicke, additional, Ploegh, Hidde L., additional, Mansour, Michael K., additional, Miranti, Cindy K., additional, Levitz, Stuart M., additional, and Vyas, Jatin M., additional

Published
2019
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13. CD82 controls CpG‐dependent TLR9 signaling

Author

Pia V. Kasperkovitz, Eva-Maria Frickel, Allison K. Lord, Stuart M. Levitz, Nida S. Khan, Paige E. Negoro, Daniel P Lukason, Zeina Dagher, Christine Becker, Mridu Acharaya, Cindy K. Miranti, Katerina Artavanis-Tsakonas, Jennifer L. Reedy, You-Me Kim, Jenny M. Tam, Hidde L. Ploegh, Jatin M. Vyas, Eicke Latz, Zaida G. Ramirez-Ortiz, Tammy Vyas, Rebecca A Ward, Marianela Feliu, Shuying Xu, Michael K. Mansour, Melanie M. Brinkmann, Lukason, Daniel P [0000-0003-1829-5735], Xu, Shuying [0000-0003-4572-8663], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, pathology [Endoplasmic Reticulum], Regulator, immunology [Signal Transduction], immunology [Endoplasmic Reticulum], Endoplasmic Reticulum, genetics [Active Transport, Cell Nucleus], Kangai-1 Protein, Biochemistry, Mice, immunology [Inflammation], 0302 clinical medicine, Tetraspanin, immunology [Toll-Like Receptor 9], immunology [NF-kappa B], immunology [Kangai-1 Protein], Mice, Knockout, myddosome, NF-kappa B, genetics [Cell Nucleus], immunology [Macrophages], tetraspanins, Cell biology, genetics [Cytokines], CPG-oligonucleotide, Oligodeoxyribonucleotides, CpG site, immunology [Cell Nucleus], Cytokines, pharmacology [Oligodeoxyribonucleotides], Signal transduction, Signal Transduction, Biotechnology, Model organisms, drug effects [Signal Transduction], genetics [Toll-Like Receptor 9], Immunology, Active Transport, Cell Nucleus, Cd82 antigen, mouse, Infectious Disease, Biology, genetics [Signal Transduction], genetics [Kangai-1 Protein], Tlr9 protein, mouse, genetics [Inflammation], 03 medical and health sciences, immunology [Active Transport, Cell Nucleus], ddc:570, drug effects [Active Transport, Cell Nucleus], Genetics, Animals, TLRs, Cell adhesion, Molecular Biology, pathology [Inflammation], Cell Nucleus, Inflammation, Innate immune system, FOS: Clinical medicine, Macrophages, Research, TLR9, Cell Biology, RAW 264.7 Cells, 030104 developmental biology, immunology [Cytokines], Toll-Like Receptor 9, genetics [Endoplasmic Reticulum], CD82, 030217 neurology & neurosurgery, pathology [Macrophages], genetics [NF-kappa B]
Abstract

The tetraspanin CD82 is a potent suppressor of tumor metastasis and regulates several processes including signal transduction, cell adhesion, motility, and aggregation. However, the mechanisms by which CD82 participates in innate immunity are unknown. We report that CD82 is a key regulator of TLR9 trafficking and signaling. TLR9 recognizes unmethylated cytosine-phosphate-guanine (CpG) motifs present in viral, bacterial, and fungal DNA. We demonstrate that TLR9 and CD82 associate in macrophages, which occurs in the endoplasmic reticulum (ER) and post-ER. Moreover, CD82 is essential for TLR9-dependent myddosome formation in response to CpG stimulation. Finally, CD82 modulates TLR9-dependent NF-��B nuclear translocation, which is critical for inflammatory cytokine production. To our knowledge, this is the first time a tetraspanin has been implicated as a key regulator of TLR signaling. Collectively, our study demonstrates that CD82 is a specific regulator of TLR9 signaling, which may be critical in cancer immunotherapy approaches and coordinating the innate immune response to pathogens.-Khan, N. S., Lukason, D. P., Feliu, M., Ward, R. A., Lord, A. K., Reedy, J. L., Ramirez-Ortiz, Z. G., Tam, J. M., Kasperkovitz, P. V., Negoro, P. E., Vyas, T. D., Xu, S., Brinkmann, M. M., Acharaya, M., Artavanis-Tsakonas, K., Frickel, E.-M., Becker, C. E., Dagher, Z., Kim, Y.-M., Latz, E., Ploegh, H. L., Mansour, M. K., Miranti, C. K., Levitz, S. M., Vyas, J. M. CD82 controls CpG-dependent TLR9 signaling.

Published
2019

14. Enantiomeric separation of meptazinol and its three intermediate enantiomers by capillary electrophoresis: quantitative analysis of meptazinol in pharmaceutical formulations.

Author

Yu J, Jiang Z, Sun T, Ji F, Xu S, Wei L, and Guo X

Subjects
Adsorption, Chemistry, Pharmaceutical, Hydrogen-Ion Concentration, Meptazinol isolation & purification, Stereoisomerism, beta-Cyclodextrins chemistry, Electrophoresis, Capillary methods, Meptazinol chemistry
Abstract

A new capillary electrophoresis (CE) method using carboxymethyl-β-cyclodextrin (CM-β-CD) as chiral selector has been developed for the enantiomeric separation of meptazinol and its three intermediate enantiomers (intermediates II-IV), and validated for the application of quantitative determination of meptazinol in tablets. The primary factors affecting the separation efficiency, which include the chiral selector and its concentration, the buffer pH and composition, the organic modifiers used, and the applied voltage, were optimized. Baseline and satisfactory separations were obtained for meptazinol and its three intermediate enantiomers. For quantitative analysis of meptazinol, the method was performed at the condition using 2.0 mmol/L CM-β-CD in 20 mmol/L H3 PO4 buffer adjusted to a pH of 6.00 with an applied voltage of 15 kV and containing 5% acetonitrile. After validation of the method in terms of its linearity, limits of detection and quantitation, accuracy, precision and selectivity, the method was successfully applied to the quantitation of meptazinol in pharmaceutical formulations., (Copyright © 2013 John Wiley & Sons, Ltd.)

Published
2014
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