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Your search keyword '"Xiao-ming Xiong"' showing total 3 results
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3 results on '"Xiao-ming Xiong"'

1. Macrophages facilitate tumor cell PD‐L1 expression via an IL‐1β‐centered loop to attenuate immune checkpoint blockade

Author

Cheng Xu, Yu Xia, Bai‐Wei Zhang, Emmanuel Kwateng Drokow, Hua‐Yi Li, Sen Xu, Zhen Wang, Si‐Yuan Wang, Ping Jin, Tian Fang, Xiao‐Ming Xiong, Pu Huang, Ning Jin, Jia‐Hong Tan, Qing Zhong, Yu‐Xin Chen, Qi Zhang, Yong Fang, Fei Ye, and Qing‐Lei Gao

Subjects
immune checkpoint blockade, interleukin‐1β, programmed death‐ligand 1, tumor‐immune microenvironment, tumor‐associated macrophages, Medicine
Abstract

Abstract Tumor‐associated macrophages (TAMs) play critical roles in reprogramming other immune cells and orchestrating antitumor immunity. However, the interplay between TAMs and tumor cells responsible for enhancing immune evasion remains insufficiently understood. Here, we revealed that interleukin (IL)‐1β was among the most abundant cytokines within the in vitro tumor‐macrophage coculture system, and enhanced IL‐1β expression was associated with impaired cytotoxicity of CD8+ T cells in human ovarian cancer, indicating the possibility that IL‐1β mediated immunosuppression during tumor‐TAMs crosstalk. Mechanistically, we demonstrated that IL‐1β significantly boosted programmed death‐ligand 1 (PD‐L1) expression in tumor cells via the activation of the nuclear factor‐κb signaling cascade. Specifically, IL‐1β released from TAMs was triggered by lactate, the anaerobic metabolite of tumor cells, in an inflammasome activation‐dependent manner. IL‐1β sustained and intensified immunosuppression by promoting C‐C motif chemokine ligand 2 secretion in tumor cells to fuel TAMs recruitment. Importantly, IL‐1β neutralizing antibody significantly curbed tumor growth and displayed synergistic antitumor efficacies with anti‐PD‐L1 antibody in tumor‐bearing mouse models. Together, this study presents an IL‐1β‐centered immunosuppressive loop between TAMs and tumor cells, highlighting IL‐1β as a candidate therapeutic target to reverse immunosuppression and potentiate immune checkpoint blockade.

Published
2023
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2. Inhibitory effect of resveratrol derivative BTM-0512 on high glucose-induced cell senescence involves dimethylaminohydrolase/asymmetric dimethylarginine pathway

Author

Da-Xiong Xiang, Yuan-Jian Li, Xiao-Ming Xiong, Jun Peng, Chen-Jing Wang, Si-Yu Liu, Chang-Ping Hu, and Qiong Yuan

Subjects
Senescence, Endothelium, Physiology, Cell, Cell Culture Techniques, Gene Expression, Resveratrol, Arginine, Nitric Oxide, Antioxidants, Amidohydrolases, Cell Line, chemistry.chemical_compound, Sirtuin 1, Physiology (medical), Stilbenes, medicine, Humans, RNA, Messenger, Cellular Senescence, Pharmacology, Dose-Response Relationship, Drug, biology, Reverse Transcriptase Polymerase Chain Reaction, Endothelial Cells, Cell biology, Endothelial stem cell, Glucose, medicine.anatomical_structure, chemistry, Biochemistry, Cell culture, biology.protein, Endothelium, Vascular, Nitric Oxide Synthase, Reactive Oxygen Species, Asymmetric dimethylarginine
Abstract

1. It has been reported that resveratrol exerts the inhibitory effects on aging through activation of sirtuin 1 (SIRT1) and dimethylarginine dimethylaminohydrolase (DDAH)/asymmetric dimethylarginine (ADMA) pathway involved in the high glucose-induced endothelial cell senescence. 2. The aims of this work were to explore whether BTM-0512, a novel derivative of resveratrol, was able to exert the beneficial effect on high glucose-induced cellular senescence through regulating the DDAH/ADMA pathway and to explore whether the regulatory effect of BTM-0512 on DDAH/ADMA pathway was related to the activation of SIRT1. 3. The senescence model of endothelial cells was induced by high glucose and the cells were collected for the determination of beta-galactosidase and DDAH activity, ADMA level, DDAH and SIRT1 mRNA expression. 4. The results showed that high glucose significantly increased the ratio of senescent cells concomitantly with the decreased DDAH activity, the downregulated DDAH2 and SIRT1 mRNA expressions and the increased ADMA levels, which were attenuated by pretreatment with BTM-0512. 5. The beneficial effects of BTM-0512 on high glucose-induced senescence were blocked by splimtomicin, the specific inhibitor of SIRT1, or by silencing DDAH2 expression. 6. The results suggest that BTM-0512 was able to exert the beneficial effects on high glucose-induced cellular senescence through regulating the DDAH/ADMA pathway, and its regulatory effect on DDAH/ADMA pathway was related to the activation of SIRT1.

Published
2010
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3. Geometric approach to VLSI layout compaction

Author

Ernest S. Kuh and Xiao-Ming Xiong

Subjects
Engineering, Vlsi layout, business.industry, Applied Mathematics, Process (computing), Compaction, Topology (electrical circuits), Integrated circuit layout, Cad system, Geometric method, Computer Science Applications, Electronic, Optical and Magnetic Materials, Jog, Hardware_INTEGRATEDCIRCUITS, Electrical and Electronic Engineering, business, Algorithm
Abstract

We present a new geometric approach to VLSI layout compaction in this paper. In contrast to existing compaction algorithms, we rely on the geometric method and bypass both compaction grids and constraint graphs during the entire compaction process. A systematic and efficient way is introduced to enumerate all possible jogs. For the given layout topology we prove that the geometric algorithm yields the minimum-area layout in one-dimensional compaction with automatic jog insertion. In the final output, only necessary jogs are inserted and the total wire length is minimized as a secondary goal. Furthermore, the integration of local compaction tools into a layout CAD system and the practical extensions of our algorithm are addressed.

Published
1990
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