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Abstract Halogenation of Y‐series small‐molecule acceptors (Y‐SMAs) is identified as an effective strategy to optimize photoelectric properties for achieving improved power‐conversion‐efficiencies (PCEs) in binary organic solar cells (OSCs). However, the effect of different halogenation in the 2D‐structured large π‐fused core of guest Y‐SMAs on ternary OSCs has not yet been systematically studied. Herein, four 2D‐conjugated Y‐SMAs (X‐QTP‐4F, including halogen‐free H‐QTP‐4F, chlorinated Cl‐QTP‐4F, brominated Br‐QTP‐4F, and iodinated I‐QTP‐4F) by attaching different halogens into 2D‐conjugation extended dibenzo[f,h]quinoxaline core are developed. Among these X‐QTP‐4F, Cl‐QTP‐4F has a higher absorption coefficient, optimized molecular crystallinity and packing, suitable cascade energy levels, and complementary absorption with PM6:L8‐BO host. Moreover, among ternary PM6:L8‐BO:X‐QTP‐4F blends, PM6:L8‐BO:Cl‐QTP‐4F obtains a more uniform and size‐suitable fibrillary network morphology, improved molecular crystallinity and packing, as well as optimized vertical phase distribution, thus boosting charge generation, transport, extraction, and suppressing energy loss of OSCs. Consequently, the PM6:L8‐BO:Cl‐QTP‐4F‐based OSCs achieve a 19.0% efficiency, which is among the state‐of‐the‐art OSCs based on 2D‐conjugated Y‐SMAs and superior to these devices based on PM6:L8‐BO host (17.70%) and with guests of H‐QTP‐4F (18.23%), Br‐QTP‐4F (18.39%), and I‐QTP‐4F (17.62%). The work indicates that halogenation in 2D‐structured dibenzo[f,h]quinoxaline core of Y‐SMAs guests is a promising strategy to gain efficient ternary OSCs.

Abstract Campylotropis xinfeniae, a new species from the dry‐hot valley of the Jinsha River in the Yunnan province, China, is described and illustrated. It is morphologically similar to C. wilsonii and C. brevifolia in having glabrescent old branches, absent stipels, 3‐foliolate leaves, and adaxially puberulent leaflets, while it differs from the latter two in having often paniculate inflorescences, obviously white standard, not incurved sickle keel, larger narrowly oblique legumes, and longer legume beak. The complete chloroplast genome of this new species is 149,073 bp in length and exhibits a typical quadripartite structure. Phylogenetic analyses based on the complete chloroplast genome also supported C. xinfeniae as a new species located at the basal distinct clade of the genus Campylotropis, clearly separated from the remaining members of the genus and its allied genera. A conservation assessment of data deficient (DD) is recommended for the new species without extensive exploring of similar habitats according to the IUCN Categories and Criteria.

Abstract Metasurfaces, 2D arrays of nanostructures, have gained significant attention in recent years due to their ability to manipulate light at the subwavelength scale. Their diverse applications range from advanced optical devices to sensing and imaging technologies. However, the mass production of dielectric metasurfaces with tailored properties for visible light has remained a challenge. Therefore, the demand for efficient and cost‐effective fabrication methods for metasurfaces has driven the continuing development of various techniques. In this research article, a high‐throughput production method is presented for multifunctional dielectric metasurfaces in the visible light range using one‐step high‐index TiO2‐polymer composite (TPC) printing, which is a variant of nanoprinting lithography (NIL) for the direct replication of patterned multifunctional dielectric metasurfaces using a TPC material as the printing ink. The batch fabrication of dielectric metasurfaces is demonstrated with controlled geometry and excellent optical response, enabling high‐performance light‐matter interactions for potential applications of visible meta‐displays.

Abstract Colorectal cancer (CRC) has become one of the most common tumours with high morbidity, mortality and distinctive evolution mechanism. The neoantigens arising from the somatic mutations have become considerable treatment targets in the management of CRC. As cancer‐specific aberrant peptides, neoantigens can trigger the robust host immune response and exert anti‐tumour effects while minimising the emergence of adverse events commonly associated with alternative therapeutic regimens. In this review, we summarised the mechanism, generation, identification and prognostic significance of neoantigens, as well as therapeutic strategies challenges of neoantigen‐based therapy in CRC. The evidence suggests that the establishment of personalised neoantigen‐based therapy holds great promise as an effective treatment approach for patients with CRC.

Soft and stretchable tactile sensors have received extensive attention for their potential applications in wearables, human–robot interaction, and intelligent robots. Herein, inspired by the functions of skin somatosensory signal generation and processing, an artificial intelligence‐motivated skin‐like optical fiber tactile (SOFT) sensor is proposed. It features multifunctional touch interaction capabilities including tactile amplitude and position and tensile strain. Four fiber Bragg gratings (FBGs) are embedded in a skin‐like three‐layer laminate structure of the SOFT sensor, forming a flexible tactile sensing array with a stretchability larger than 20%. Fusing the two‐level cascaded neural network, the position and magnitude of the contact force can be distinguished simultaneously. The recognition accuracy for contact position is up to 92.41% and the error is less than 4.2% within the force range of 0–3.5 N. Several SOFT sensor‐based interactive applications including pressure password interface and music playback are achieved by combining the artificial intelligence spatiotemporal dynamic logic analysis. Furthermore, the sensor is also capable of complex scenes involving tension and tactile sensing, such as dexterous hand perception and human–robot interaction control. This work provides novel insights into artificial intelligence‐based integrated skin that shows broad promise in intelligent prosthetics and bionic robotic.

Abstract With the advancement of information technology and the reduction of costs, the application of unmanned aerial vehicle (UAV) has gradually expanded from the military field to the industrial field and civilian field. It brings great convenience to people in surveillance, detection, transportation, emergency rescue etc. However, UAVs usually work in harsh natural environments, and their communication security confronts various challenges. Due to UAVs' limited resources, such as computing capability, storage space, and energy, traditional security protection schemes based on complex cryptographic algorithms are not suitable for UAV systems directly. Therefore, a two‐stage lightweight identity authentication and key agreement protocol for UAV is proposed in this paper. The entire process only uses hash and XOR operations, which significantly improves the authentication efficiency. Simultaneously, the physical unclonable function (PUF) is introduced and embedded into the UAV hardware to ensure UAV network communication security when a UAV suffers a physical capture attack. In the paper, the security of the proposed protocol is proved with Burrows–Abadi–Needham (BAN) logic, Real‐or‐Random (ROR) model, and AVISPA simulation tools. An informal security analysis is also provided to illustrate that the protocol satisfies the security requirements of UAV networks. Finally, the protocol is compared with other existing protocols regarding function properties, computation cost, and communication cost, which shows that the proposed protocol has effectiveness and practicality.

Abstract The use of deuterium are critical for promoting the fundamental understanding of aggregate materials and their new functions. Particularly, the solution structure of conjugated polymers can be hardly resolved without deuteration. However, studies about the isotopic effects of casting solvents on the aggregated structures of photovoltaic polymers and their bulk‐heterojunction blends are deficient. Here, the impact of deuterated solvents on the thermal behavior, aggregated structures, and device performance of photovoltaic polymers is clearly delineated for the first time by multiple techniques. The enhanced π‐π stacking order of photovoltaic polymers is highly relevant to their relatively poor miscibility with deuterated solvents. Benefiting from higher crystallinity and optimized morphology of deuterated solvents processed films, the devices are able to achieve better efficiency and notable improvement in thermal stability. Our results highlight the isotopic effects of solvents on the aggregated structure of conjugated polymer systems and reveal the potential of innovative approaches to fabricate thermally stable high‐efficiency solar cells.

Abstract Graphene is a promising candidate for the next‐generation infrared array image sensors at room temperature due to its high mobility, tunable energy band, wide band absorption, and compatibility with complementary metal oxide semiconductor process. However, it is difficult to simultaneously obtain ultrafast response time and ultrahigh responsivity, which limits the further improvement of graphene photoconductive devices. Here, a novel graphene/C60/bismuth telluride/C60/graphene vertical heterojunction phototransistor is proposed. The response spectral range covers 400–1800 nm; the responsivity peak is 106 A W−1; and the peak detection rate and peak response speed reach 1014 Jones and 250 µs, respectively. In addition, the regulation of positive and negative photocurrents at a gate voltage is characterized and the ionization process in impurities of the designed phototransistor at a low temperature is analyzed. Tunable bidirectional response provides a new degree of freedom for phototransistors' signal resolution. The analysis of the dynamic change process of impurity energy level is conducted to improve the device's performance. From the perspective of manufacturing process, the ultrathin phototransistor (20–30 nm) is compatible with functional metasurface to realize wavelength or polarization selection, making it possible to achieve large‐scale production of integrated spectrometer or polarization imaging sensor by nanoimprinting process.

Humanoid tactility has been boosting robotic intelligence in object recognition, dexterous manipulation, and human–robot interaction. For many artificial tactile sensors, especially those based on optical principles, inflexibility, bulkiness, and monomodality limit their potential to function as humanoid skins. Herein, by embedding lab‐made optical nanofibers (ONFs) into elastomeric films, soft, flexible, thin (around 500 μm, similar to human skin), and multimodal (force and thermosensitive) robotic skins are achieved. These superior characteristics arise from the low flexural rigidity and large evanescent field of ONFs, due to their subwavelength diameters (down to 450 nm). By tuning light wavelength, ONF diameter, and skin thickness, variable sensitivities and sensing ranges for both force and temperature are reported. Depending on different sensing requirements, special modules can be further assembled on the ONF skins for various surface properties, including hardness, texture, and thermal conductivity. The ONF skins can enable a commercial robot to emulate human behaviors, including adaptive grasping of flimsy objects, contactless temperature measurement, and even the perception of leaf veins. It is anticipated that these ONF skins could offer a unique solution in multiple intelligent systems such as robotics, prosthetics, human–machine interface and wearable devices.

Abstract Background To date, there is no approved blood‐based biomarker for breast cancer detection. Herein, we aimed to assess semaphorin 4C (SEMA4C), a pivotal protein involved in breast cancer progression, as a serum diagnostic biomarker. Methods We included 6,213 consecutive inpatients from Tongji Hospital, Qilu Hospital, and Hubei Cancer Hospital. Training cohort and two validation cohorts were introduced for diagnostic exploration and validation. A pan‐cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors. Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed. We hypothesized that increased pre‐treatment serum SEMA4C levels, measured using optimized in‐house enzyme‐linked immunosorbent assay kits, could detect breast cancer. The endpoints were diagnostic performance, including area under the receiver operating characteristic curve (AUC), sensitivity, and specificity. Post‐surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification. There was no restriction on disease stage for eligibilities. Results We included 2667 inpatients with breast lesions, 2378 patients with other solid tumors, and 1168 healthy participants. Specifically, 118 patients with breast cancer were diagnosed with stage 0 (5.71%), 620 with stage I (30.00%), 966 with stage II (46.73%), 217 with stage III (10.50%), and 8 with stage IV (0.39%). Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls (P < 0.001). Elevated serum SEMA4C levels had AUC of 0.920 (95% confidence interval [CI]: 0.900–0.941) and 0.932 (95%CI: 0.911–0.953) for breast cancer detection in the two validation cohorts. The AUCs for detecting early‐stage breast cancer (n = 366) and ductal carcinoma in situ (n = 85) were 0.931 (95%CI: 0.916–0.946) and 0.879 (95%CI: 0.832–0.925), respectively. Serum SEMA4C levels significantly decreased after surgery, and the reduction was more striking after modified radical mastectomy, compared with mass excision (P < 0.001). The positive rate of enhanced serum SEMA4C levels was 84.77% for breast cancer and below 20.75% for the other 14 solid tumors. Conclusions Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis. However, validation in prospective settings and by other study groups is warranted.

Abstract The data of lightning flash count, rainfall, radar reflectivity, vertical wind shear (WS), surface dew point temperature (DP) and particulate matter up to 10 μm in size (PM10) over Guilin, China from July 2010 to December 2019 were studied to check whether aerosol invigoration effect (AIV) exists in the study area. It was found that convective rainfall fluctuates less when compared with lightning in convective system. A hypothesis was put forward that the difference in fluctuations between convective rainfall and lightning is attributed to AIV. To test this hypothesis, lightning yield, which is defined as the ratio between lightning and rainfall, was analyzed. It was found that lightning yield has a positive correlation with PM10 when WS is low and DP is high for convective precipitation. It was also found that for the weak WS cases, when aerosol conditions are shifted from super pristine to the optimal concentration (Nop), lightning yield increases with increasing PM10; whereas for concentrations greater than Nop, lightning yield decreases with increasing PM10. Nop would be larger for higher DP. The results are in line with the previous studies showing that AIV depends strongly on weak wind shear and/or warm cloud base. This suggests that AIV exists in the study area, and suggests that the hypothesis is reasonable, and lightning yield can be used as a surrogate to study AIV.

Abstract Low symmetric two dimensional (2D) semiconductors are of great significance for their potential applications in polarization‐sensitive photodetection and quantum information devices. However, their real applications are limited by their photo‐detecting wavelength ranges, which are restricted by their fundamental optical bandgaps. Recently, intercalation has been demonstrated to be a powerful strategy to modulate the optical bandgaps of 2D semiconductors. Here, the authors report the self‐driven oxygen (O2) intercalation induced bandgap reduction from 1.75 to 1.19 eV in gallium telluride (GaTe) in air. This bandgap shrinkage provides the long‐wavelength detection threshold above ≈1100 nm for O2 intercalated GaTe (referred to as GaTeO2), well beyond the cut‐off wavelength at ≈708 nm for pristine GaTe. The GaTeO2 photodetectors have a high photoresponsivity, and highly anisotropic photodetection behavior to even sub‐waveband radiation. The dichroic ratio (Imax/Imin) of photocurrent is about 1.39 and 2.9 for 600 nm and 1100 nm, respectively. This findings demonstrates a broadband photodetector utilizing GaTe after breaking through its bandgap limitation by self‐driven O2 intercalation in air and further reveal its photoconductivity anisotropic nature. This provides design strategies of 2D materials‐based high‐performance broadband photodetectors for the exploration of polarized state information.

Abstract Mixed‐halide perovskites can undergo a photoinduced phase segregation. Even though many reports have claimed that such a phase segregation process is reversible, what happens after phase segregation and its impact on the performance of perovskite‐based devices are still open questions. Here, the phase transformation of MAPb(I1−xBrx)3 after phase segregation and probe an irreversible phase reconstruction of MAPbBr3 is investigated. The photoluminescence imaging microscopy technique is introduced to in situ record the whole process. It is proposed that the type‐I band alignment of segregated I‐rich and Br‐rich domains can enhance the emission of the I‐rich domains by suppressing the nonradiative recombination channels. At the same time, the charge injection from Br‐rich to I‐rich domains drives the expulsion of iodide from the lattice, and thus triggers the reconstruction of MAPbBr3. The work highlights the significance of ion movements in mixed‐halide perovskites and provides new perspectives to understand the property evolution.

Abstract Optical metasurfaces enable novel ways to locally manipulate light's amplitude, phase, and polarization, underpinning a newly viable technology for applications, such as high‐density optical storage, holography, and displays. Here, a high‐security‐level platform enabled by centimeter‐scale plasmonic metasurfaces with full‐color, high‐purity, and enhanced‐information‐capacity properties is proposed. Multiple types of independent information can be embedded into a single metamark using full parameters of light, including amplitude, phase, and polarization. Under incoherent white light, the metamark appears as a polarization‐ and angle‐encoded full‐color image with flexibly controlled hue, saturation, and brightness, while switching to multiwavelength holograms under coherent laser illumination. More importantly, for actual applications, the extremely shallow functional layer makes such centimeter‐scale plasmonic metamarks suitable for cost‐effective mass production processes. Considering these superior performances of the presented multifunctional plasmonic metasurfaces, this work may find wide applications in anticounterfeiting, information security, high‐density optical storage, and so forth.

Abstract Phosphoinositide 3‐kinases, delta (PI3Kδ) and gamma (PI3Kγ) are enriched in immune cells and regulate the development and function of innate and adaptive immunity. Dual PI3Kδγ inhibitors are considered high value targets for their potential to treat a variety of immune‐mediated diseases, but their discovery has been challenging. Here we describe the preclinical pharmacology of HM5023507, an orally active dual inhibitor of δγ isoforms in immune signaling. HM5023507 inhibited PI3Kδ and PI3Kγ isoforms with greater than 100‐fold selectivity against PI3Kα and PI3Kβ in recombinant enzymatic assays and in primary human immune cells with an exquisite selectivity against other targets. HM5023507 attenuated the PI3Kδ/γ signaling in human basophils (IC50: 42/340 nmol/L; selectivity ratio ~1:8). HM5023507 attenuated the activation and function of human B and T cells, Th17 differentiation of CD4 T cells in the blood of healthy donors and rheumatoid arthritis patients, and cytokine and IgG production in human T and B cell cocultures, in vitro. Orally dosed HM5023507 attenuated PI3K δ/γ‐mediated immune signaling in the rat in a dose‐related manner. In addition, HM5023507 inhibited semiestablished collagen‐induced arthritic inflammation in the rats (ED50 of 0.25mg/kg, p.o. BID or 0.5 mg/kg, QD, AUC: 1422 ng/mL*h), improved histopathology‐ and micro‐computed tomography (µCT)‐based indices of joint damage, bone destruction, and attenuated the levels of anti‐collagen antibody, with an overall anti‐inflammatory profile matching that of a TNFα neutralizing antibody. The PI3K δγ inhibitory profile of HM5023507 and its selectivity make it a useful tool to further delineate immunobiology of dual PI3K δγ targeting.

The existing motor frame is made of metal materials. In this paper, a carbon fiber reinforced plastic (CFRP) motor frame, which uses material damping to reduce vibration amplitude, which is proposed to design and manufacture low-vibration motors. The damp ratio of the CFRP motor frame is calculated by the damp prediction model based on strain energy, which is verified by the combination of the finite element method and experiment. The vibration characteristics of the CFRP frame motor are studied experimentally and compared with that of the metal frame motor. The results show that the CFRP frame motor has good vibration reduction. The amplitude reduction is up to 5 times higher than that of the metal motor frame, which proves that the damping vibration reduction of the CFRP motor frame has a good application value.

Abstract Catenary functions are exciting and fundamental building blocks in constructing various kinds of waves in subwavelength structures. Here, a simple yet powerful approach inspired by catenary optics is proposed to realize efficient manipulation of electromagnetic waves in terms of both amplitude and phase. By properly engineering the catenary electromagnetic fields and frequency dispersion, lightweight metafilm‐based broadband absorbers with polarization‐independent bandwidth covering 0.65–6.2 GHz are experimentally achieved, and the bandwidth is further broadened to 0.9–40 GHz. With the same approach, a large‐scale flat antenna based on generalized reflection is demonstrated in the satellite communication system. To enable the batch manufacturing, a flexible substrate–based microfabrication process is developed with a minimum feature size of down to sub‐micrometer and total size up to almost 1 m. These results may provide important guidance for the design of metasurface‐based devices.