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Your search keyword '"Won Kyoung Choi"' showing total 2 results
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2 results on '"Won Kyoung Choi"'

1. ChemInform Abstract: New Diarylureas and Diarylamides Containing 1,3,4-Triarylpyrazole Scaffold: Synthesis, Antiproliferative Evaluation Against Melanoma Cell Lines, ERK Kinase Inhibition, and Molecular Docking Studies

Author

Chang-Hyun Oh, Hong Seok Choi, Mohammed I. El-Gamal, Daejin Baek, and Won-Kyoung Choi

Subjects
Scaffold, Cell culture, Chemistry, Melanoma cell line, Extracellular signal-regulated kinases, Cancer research, Potency, Human melanoma, General Medicine
Abstract

Derivatives (Ib)—(Id), and (IIIa)—(IIIc) show the highest potency against A375P human melanoma cell line.

Published
2012

2. ChemInform Abstract: Synthesis and Antiproliferative Activities of 1-Substituted-3-(3-chloro-5-methoxyphenyl)-4-pyridinylpyrazole Derivatives Against Melanoma Cell Line

Author

Chang-Hyun Oh and Won-Kyoung Choi

Subjects
Sorafenib, Chemistry, Cell culture, Stereochemistry, Melanoma cell line, medicine, Human melanoma, General Medicine, In vitro, medicine.drug
Abstract

The synthesis of a new series of diarylureas and amides having a 1-substituted-3-(3-chloro-5-methoxyphenyl)-4-pyridinylpyrazole scaffold is reported here. The in vitro antiproliferative activities of these diaryl derivatives against human melanoma cell line A375 were tested and the effect of substituents on the phenyl ring was investigated. Most of the newly synthesized compounds generally showed superior or similiar activity against A375 to Sorafenib. Among these compounds, IId, IIg and IIh showed excellent activity against A375 compared to Sorafenib.

Published
2010

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