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45 results on '"Williams, Ashley"'

1. Community testing practices for autism within the autism and developmental disabilities monitoring network

Author

Robinson Williams, Ashley, primary, Amoakohene, Esther, additional, Maenner, Matthew J., additional, Zahorodny, Walter, additional, DiRienzo, Monica, additional, Grzybowski, Andrea, additional, Hall‐Lande, Jennifer, additional, Pas, Elise T., additional, Bakian, Amanda V., additional, Lopez, Maya, additional, Patrick, Mary, additional, Shenouda, Josephine, additional, and Shaw, Kelly A., additional

Published
2024
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3. Therapeutic games to reduce anxiety and depression in young people: A systematic review and exploratory meta‐analysis of their use and effectiveness

Author

Eve, Zarah, primary, Turner, Martin, additional, Di Basilio, Daniela, additional, Harkin, Benjamin, additional, Yates, Alan, additional, Persson, Sofia, additional, Henry, John, additional, Williams, Ashley, additional, Walton, Geoff, additional, Jones, Marc V., additional, Whitley, Charlotte, additional, and Craddock, Nathan, additional

Published
2023
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7. Therapeutic games (TGs) to reduce anxiety and depression in young people: a systematic review and exploratory meta-analysis of their use and effectiveness

Author

Eve, Zarah, Turner, Martin, Di Basilio, Daniela, Harkin, Benjamin, Yates, Alan, Perrson, Sofia, Henry, John, Williams, Ashley, Walton, Geoff, Jones, Marc, Whitley, Charlotte, Craddock, Nathan, Eve, Zarah, Turner, Martin, Di Basilio, Daniela, Harkin, Benjamin, Yates, Alan, Perrson, Sofia, Henry, John, Williams, Ashley, Walton, Geoff, Jones, Marc, Whitley, Charlotte, and Craddock, Nathan

Abstract

Objective: The development of serious games for mental wellbeing is a topic of growing interest. The increase in acceptance of games as a mainstream entertainment medium combined with the immersive qualities of games provide opportunities for meaningful support and intervention in mental wellbeing. Method: We conducted a systematic review and exploratory meta-analysis to examine if aspects of the interventions influenced outcomes as measured via overall effect sizes. We employed a multilevel meta-analytic approach to accommodate the interdependency of effect sizes (18 effect sizes from 14 studies, with 2027 participants). Results: Overall, the main effect for gaming interventions on any outcome variable was small to medium sized, d = 0.35 (CI: .23, 47, p < .001). Results revealed that the only significant moderator was the nature of the intervention. Specifically, only interventions that included a Rational Emotional Behavioural focus significantly predicted an improvement in depression and/or anxiety in participants. Conclusion: The findings reveal promising effects for therapeutic games (TGs) for mental health, but replications are needed, alongside the addressing of methodological and procedural concerns.

Published
2023

11. The Impact of Water on Choline‐2‐Octenoic Ionic Liquid‐Facilitated Transdermal Transport (Adv. Therap. 1/2023)

Author

Nichols, Isabel R., primary, Hamadani, Christine M., additional, Chism, Claylee M., additional, Hunter, Alysha N., additional, Ahmad, Humayun, additional, Wontor, Kendall, additional, Williams, Ashley E., additional, Vashisth, Priyavrat, additional, Hammer, Nathan I., additional, Kundu, Santanu, additional, and Tanner, Eden E. L., additional

Published
2023
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25. Discovery of Quinoline-Derived Trifluoromethyl Alcohols, Determination of Their in vivo Toxicity and Anticancer Activity in a Zebrafish Embryo Model

Author

Sittaramane, Vinoth, primary, Padgett, Jihan, additional, Salter, Philip, additional, Williams, Ashley, additional, Luke, Shauntelle, additional, McCall, Rebecca, additional, Arambula, Jonathan F., additional, Graves, Vincent B., additional, Blocker, Mark, additional, Van Leuven, David, additional, Bowe, Keturah, additional, Heimberger, Julia, additional, Cade, Hannah C., additional, Immaneni, Supriya, additional, and Shaikh, Abid, additional

Published
2015
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41. Early articular cartilage MRI T2 changes after anterior cruciate ligament reconstruction correlate with later changes in T2 and cartilage thickness.

Author

Williams A, Winalski CS, and Chu CR

Subjects
Adult, Anterior Cruciate Ligament Reconstruction, Female, Humans, Male, Middle Aged, Postoperative Period, Prospective Studies, Young Adult, Cartilage, Articular diagnostic imaging, Knee Joint diagnostic imaging, Magnetic Resonance Imaging, Postoperative Complications diagnostic imaging
Abstract

Anterior cruciate ligament (ACL) injury is a known risk factor for future development of osteoarthritis (OA). This human clinical study seeks to determine if early changes to cartilage MRI T2 maps between baseline and 6 months following ACL reconstruction (ACLR) are associated with changes to cartilage T2 and cartilage thickness between baseline and 2 years after ACLR. Changes to T2 texture metrics and T2 mean values in medial knee cartilage of 17 human subjects 6 months after ACLR were compared to 2-year changes in T2 and in cartilage thickness of the same areas. T2 texture and mean assessments were also compared to that of 11 uninjured controls. In ACLR subjects, six-month changes in mean T2 correlated to 2-year changes in mean T2 (R = 0.80, p = 0.0001), and 6-month changes to T2 texture metrics, but not T2 mean, correlated with 2-year changes in medial femoral cartilage thickness in 9 of the 20 texture features assessed (R = 0.48-0.72, p ≤ 0.05). Both mean T2 and texture differed (p < 0.05) between ALCR subjects and uninjured controls., Clinical Significance: These results show that short-term longitudinal evaluation of T2 map and textural changes may provide early warning of cartilage at risk for progressive degeneration after ACL injury and reconstruction. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:699-706, 2017., (© 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.)

Published
2017
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42. Repeatability of ultrashort echo time-based two-component T2* measurements on cartilages in human knee at 3 T.

Author

Qian Y, Williams AA, Chu CR, and Boada FE

Subjects
Adult, Female, Humans, Male, Reproducibility of Results, Sensitivity and Specificity, Algorithms, Artifacts, Cartilage, Articular anatomy & histology, Image Enhancement methods, Image Interpretation, Computer-Assisted methods, Knee Joint anatomy & histology, Magnetic Resonance Imaging methods
Abstract

Repeatability of in vivo measurement of multicomponent T2* relaxation in articular cartialges in human knee is important to clinical use. This study evaluated the repeatability of two-component T2* relaxation on seven healthy human subjects. The left knee was scanned once a day in three consecutive days, on a clinical 3T MRI scanner with eight-channel knee coil and ultrashort echo time pulse sequence at 11 echo times=0.6-40 ms. The intrasubject and intersubject repeatability was evaluated via coefficient of variation (CV=standard deviation/mean) in four typical cartilage regions: patellar, anterior articular, femoral, and tibial regions. It was found that the intrasubject repeatability was good, with CV<10% for the short- and long-T2* relaxation time in the layered regions in the four cartilages (with one exception) and CV<13% for the component intensity fraction (with two exceptions). The intersubject repeatability was also good, with CV∼8% (range 1-15%) for the short- and long-T2* relaxation time and CV∼10% (range 2-20%) for the component intensity fraction. The long-T2* component showed significantly better repeatability (CV∼8%) than the short-T2* component (CV∼12%) (P<0.005). These CV values suggest that in vivo measurement of two-component T2* relaxation in the knee cartilages is repeatable on clinical scanner at 3 T, with a signal-to-noise ratio of 90., (Copyright © 2012 Wiley Periodicals, Inc.)

Published
2013
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43. Multicomponent T2* mapping of knee cartilage: technical feasibility ex vivo.

Author

Qian Y, Williams AA, Chu CR, and Boada FE

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Feasibility Studies, Female, Humans, Image Enhancement methods, In Vitro Techniques, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Young Adult, Algorithms, Cartilage, Articular pathology, Image Interpretation, Computer-Assisted methods, Magnetic Resonance Imaging methods, Osteoarthritis, Knee pathology
Abstract

Disorganization of collagen fibers is a sign of early-stage cartilage degeneration in osteoarthritic knees. Water molecules trapped within well-organized collagen fibrils would be sensitive to collagen alterations. Multicomponent effective transverse relaxation (T2*) mapping with ultrashort echo time acquisitions is here proposed to probe short T(2) relaxations in those trapped water molecules. Six human tibial plateau explants were scanned on a 3T MRI scanner using a home-developed ultrashort echo time sequence with echo times optimized via Monte Carlo simulations. Time constants and component intensities of T2* decays were calculated at individual pixels, using the nonnegative least squares algorithm. Four T2*-decay types were found: 99% of cartilage pixels having mono-, bi-, or nonexponential decay, and 1% showing triexponential decay. Short T2* was mainly in 1-6 ms, while long T2* was ∼ 22 ms. A map of decay types presented spatial distribution of these T2* decays. These results showed the technical feasibility of multicomponent T2* mapping on human knee cartilage explants.

Published
2010
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44. Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content.

Author

Bear DM, Williams A, Chu CT, Coyle CH, and Chu CR

Subjects
Cadaver, Cartilage, Articular metabolism, Chondrocytes metabolism, Chondrocytes pathology, Collagen Type II metabolism, Glycosaminoglycans metabolism, Humans, Image Interpretation, Computer-Assisted, Image Processing, Computer-Assisted, Menisci, Tibial metabolism, Microscopy, Polarization, Osteoarthritis, Knee pathology, Osteoarthritis, Knee surgery, Reproducibility of Results, Cartilage, Articular pathology, Extracellular Matrix pathology, Magnetic Resonance Imaging methods, Menisci, Tibial pathology, Tomography, Optical Coherence
Abstract

Optical coherence tomography (OCT) and T2 mapping are emerging clinical imaging technologies with potential to detect subsurface changes in cartilage retaining a macroscopically intact articular surface. This study tests the hypothesis that OCT correlates with magnetic resonance imaging (MRI) T2 values, and that OCT signal is sensitive to cartilage matrix degeneration. Forty-five osteochondral cores were harvested from five human tibial plateau explants after MRI T2 mapping. Cores underwent OCT imaging and were graded as follows: A, obvious birefringence; B, no birefringence; C, subsurface voids and/or irregular surface. Extracellular matrix content was determined and cores underwent histologic and polarized light microscopy (PLM) evaluation. Grade B and C cores had 25% higher superficial T2 values (p = 0.047) and 50% higher deep T2 values (p = 0.012) than grade A cores. Grade B and C cores had 36% higher glycosaminoglycan (GAG) content compared to grade A cores (p = 0.009). Histology and PLM demonstrated increased surface irregularity and structural disorganization with increasing OCT grade. OCT grade and T2 value increased with increasing collagen disorganization, suggesting that MRI T2 mapping and OCT are sensitive to changes in collagen structure. Our results demonstrate the ability of OCT and T2 mapping to detect early cartilage degeneration in clinically normal appearing cartilage.

Published
2010
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45. Suitability of T(1Gd) as the dGEMRIC index at 1.5T and 3.0T.

Author

Williams A, Mikulis B, Krishnan N, Gray M, McKenzie C, and Burstein D

Subjects
Humans, Cartilage chemistry, Gadolinium, Glycosaminoglycans analysis, Magnetic Resonance Imaging methods
Abstract

Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is based on the theory that Gd-DTPA(2-) will distribute in inverse relation to cartilage glycosaminoglycan (GAG). T(1Gd) (T(1) after penetration of a 0.2 mmol/kg dose of Gd-DTPA(2-)) has been used as the dGEMRIC index, although (1/T(1Gd)-1/T(1o)) should be more representative of Gd-DTPA(2-) concentration (where T(1o) = T(1) before contrast). T(1o) and T(1Gd) were measured in 20 volunteers at both 1.5T and 3T and the correlation between the metrics of T(1Gd) and (1/T(1Gd)-1/T(1o)) was calculated. There was a high correlation coefficient between the two metrics at both field strengths, with R = 0.94, 0.93, and 0.90 for central medial femur, posterior medial femur, and medial tibia, respectively, at 1.5T and 0.87, 0.94, 0.96 at 3T. In all cases P < 0.0001. Therefore, these data suggest that, for native cartilage, the current practice of measuring T(1Gd) (but not also T(1o)) is adequate at both 1.5T and 3T.

Published
2007
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