1. Increased risk of stroke after radiation to the neck
- Author
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Lucille D.A. Dorresteijn, Willem J. Klokman, A.J.M. Balm, Willem Boogerd, Arnoud C. Kappelle, and Ronald B. Keus
- Subjects
medicine.medical_specialty ,education.field_of_study ,Adenoma ,business.industry ,medicine.medical_treatment ,Incidence (epidemiology) ,Population ,medicine.disease ,Surgery ,Radiation therapy ,Pleomorphic adenoma ,Otorhinolaryngology ,Relative risk ,Carcinoma ,Medicine ,cardiovascular diseases ,Radiology ,business ,education ,Stroke - Abstract
Ojective. Data from the literature about the incidence of stroke after radiotherapy on carotid arteries is limited and controversial. We investigated in a systematic manner the risk of stroke after radiotherapy to the neck. Patients and methods. Stroke is recorded in patients with T1 or T2 laryngeal carcinoma, pleomorphic adenoma, and parotid carcinoma, who have been treated with local radiotherapy, and from whom complete follow-up is available. TIA and subarachnoid haemorrhage are excluded. The relative risk of stroke is determined by comparison with population stroke-incidence register, adjusted for sex and age. Risk factors for stroke (hypertension, smoking, hypercholesterolaemia, diabetes) are registered. Results. Two hundred and fifty-five patients were analysed: follow-up period 0–22 years (median 6 years); 120 laryngeal carcinoma (778 follow-up years); 65 pleomorphic adenoma (625 follow-up years); 70 parotid carcinoma (384 follow-up years). Incidence of stroke: laryngeal carcinoma, eight (expected 0.923; OR 8.67; 95% CI 3.74–17.07); pleiomorphic adenoma, three (all on the radiotherapy side; expected 0.330; OR 9.09; 95% CI 1.88–26.57); parotid carcinoma, 0 (exp. 0.097). The analysis risk factors remains inconclusive as the sample size is too small. Conclusion. Radiation to the neck increases the risk of stroke significantly (P
- Published
- 2000
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