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Your search keyword '"Wiederstein, Markus"' showing total 7 results
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7 results on '"Wiederstein, Markus"'

1. Backbone distortions in lactam‐bridged helical peptides

Author

Moazzam, Ali, primary, Stanojlovic, Vesna, additional, Hinterholzer, Arthur, additional, Holzner, Christoph, additional, Roschger, Cornelia, additional, Zierer, Andreas, additional, Wiederstein, Markus, additional, Schubert, Mario, additional, and Cabrele, Chiara, additional

Published
2022
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2. Bet v 1 from birch pollen is a hypoallergen with vitamin D3 in the pocket

Author

Hufnagl, Karin, primary, Kromp, Livia, additional, Bianchini, Rodolfo, additional, Afify, Sheriene Moussa, additional, Wiederstein, Markus, additional, Redegeld, Frank A., additional, Zuvalova, Iveta, additional, Dvorak, Zdenek, additional, Hofstetter, Gerlinde, additional, Roth‐Walter, Franziska, additional, Pacios, Luis F., additional, and Jensen‐Jarolim, Erika, additional

Published
2021
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3. Retinoic acid‐loading of the major birch pollen allergen Bet v 1 may improve specific allergen immunotherapy: In silico, in vitro and in vivo data in BALB/c mice

Author

Hufnagl, Karin, primary, Afify, Sheriene Moussa, additional, Braun, Nina, additional, Wagner, Stefanie, additional, Wallner, Michael, additional, Hauser, Michael, additional, Wiederstein, Markus, additional, Gadermaier, Gabriele, additional, Wildner, Sabrina, additional, Redegeld, Frank A., additional, Blokhuis, Bart R., additional, Hofstetter, Gerlinde, additional, Pali‐Schöll, Isabella, additional, Roth‐Walter, Franziska, additional, Pacios, Luis F., additional, and Jensen‐Jarolim, Erika, additional

Published
2020
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4. International Journal of Cancer / Synergistic crosstalk of hedgehog and interleukin6 signaling drives growth of basal cell carcinoma

Author

Sternberg, Christina, Gruber, Wolfgang, Eberl, Markus, Tesanovic, Suzana, Stadler, Manuela, Elmer, Dominik P., Schlederer, Michaela, Grund, Sandra, Roos, Simone, Wolff, Florian, Kaur, Supreet, Mangelberger, Doris, Lehrach, Hans, Hache, Hendrik, Wierling, Christoph, Laimer, Josef, Lackner, Peter, Wiederstein, Markus, Kasper, Maria, Risch, Angela, Petzelbauer, Peter, Moriggl, Richard, Kenner, Lukas, and Aberger, Fritz

Subjects
animal structures, integumentary system, basal cell carcinoma, hedgehog, GLI signaling, STAT transcription factors, skin and connective tissue diseases, GLI transcription factors, interleukin6 signaling
Abstract

Persistent activation of hedgehog (HH)/GLI signaling accounts for the development of basal cell carcinoma (BCC), a very frequent nonmelanoma skin cancer with rising incidence. Targeting HH/GLI signaling by approved pathway inhibitors can provide significant therapeutic benefit to BCC patients. However, limited response rates, development of drug resistance, and severe side effects of HH pathway inhibitors call for improved treatment strategies such as rational combination therapies simultaneously inhibiting HH/GLI and cooperative signals promoting the oncogenic activity of HH/GLI. In this study, we identified the interleukin6 (IL6) pathway as a novel synergistic signal promoting oncogenic HH/GLI via STAT3 activation. Mechanistically, we provide evidence that signal integration of IL6 and HH/GLI occurs at the level of cisregulatory sequences by cobinding of GLI and STAT3 to common HHIL6 target gene promoters. Genetic inactivation of Il6 signaling in a mouse model of BCC significantly reduced in vivo tumor growth by interfering with HH/GLIdriven BCC proliferation. Our genetic and pharmacologic data suggest that combinatorial HHIL6 pathway blockade is a promising approach to efficiently arrest cancer growth in BCC patients. (VLID)3012344

Published
2018

5. Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma

Author

Sternberg, Christina, primary, Gruber, Wolfgang, additional, Eberl, Markus, additional, Tesanovic, Suzana, additional, Stadler, Manuela, additional, Elmer, Dominik P., additional, Schlederer, Michaela, additional, Grund, Sandra, additional, Roos, Simone, additional, Wolff, Florian, additional, Kaur, Supreet, additional, Mangelberger, Doris, additional, Lehrach, Hans, additional, Hache, Hendrik, additional, Wierling, Christoph, additional, Laimer, Josef, additional, Lackner, Peter, additional, Wiederstein, Markus, additional, Kasper, Maria, additional, Risch, Angela, additional, Petzelbauer, Peter, additional, Moriggl, Richard, additional, Kenner, Lukas, additional, and Aberger, Fritz, additional

Published
2018
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