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5 results on '"Weimer, L"'

4. A Case Series of Isolated Smiling Tremor: What Is the Phenomenology?

Author

Radmard S, Amlang CJ, Weimer L, and Pullman SL

Subjects
Humans, Tremor diagnosis, Facial Expression, Facial Muscles, Smiling physiology, Movement Disorders
Abstract

Background: Five cases of tremor only upon smiling have been reported where no facial tremor is present at rest, when talking, or with full smile., Cases: This report highlights four cases of tremor upon partial smiling, discusses the phenomenology of smiling tremor, and reviews the current literature. Four subjects with lower facial tremor present only upon smiling underwent movement disorders evaluation with video. Tremor frequencies were determined by parsing the video clips into 1-second intervals and averaging the number of oscillations per interval and were determined to be high-frequency 8 to 10 Hz irregular facial tremors with harmonic variations upon moderate effort in all cases. Slight or full-effort smiling did not elicit facial muscle oscillations. Subjects had no other signs of tremor, dystonia, or parkinsonism on examination or in family history., Conclusions: Tremor upon smiling only, or isolated smiling tremor, is a unique task- and position-specific tremor of the facial musculature., (© 2023 International Parkinson and Movement Disorder Society.)

Published
2024
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5. The mutational archive in proviral DNA does not change during 24 months of continuous or intermittent highly active antiretroviral therapy.

Author

Palmisano L, Giuliano M, Galluzzo CM, Amici R, Andreotti M, Weimer LE, Pirillo MF, Fragola V, Bucciardini R, and Vella S

Subjects
Adult, Aged, DNA Mutational Analysis, DNA, Viral drug effects, Drug Resistance, Viral genetics, Female, HIV Infections drug therapy, Humans, Italy, Male, Middle Aged, Mutation, RNA, Viral analysis, Time Factors, Young Adult, Anti-Retroviral Agents administration & dosage, Antiretroviral Therapy, Highly Active methods, DNA, Viral genetics, HIV Infections virology, HIV-1 genetics, Proviruses genetics
Abstract

Objectives: The aim of the study was to determine the modifications of the mutational archive in proviral HIV-1 DNA occurring during 24 months of intermittent or continuous highly active antiretroviral therapy (HAART)., Methods: The study population included subjects enrolled in the Istituto Superiore di Sanità Pulsed Antiretroviral Therapy (ISS PART) clinical trial. All of these patients were on first-line HAART and had plasma HIV-1 RNA below 50 HIV-1 RNA copies/mL. A genotypic resistance test was performed on HIV-1 DNA extracted from peripheral blood mononuclear cells (PBMC) at baseline and after 24 months of follow-up. Resistance-associated mutations (RAMs) were defined according to the International AIDS Society (IAS) USA classification., Results: Sixty-nine subjects were included in the study [36 enrolled in arm A of the ISS PART (continuous HAART) and 33 enrolled in arm B (intermittent HAART)]. No major modifications of the mutational archive were found in either group after 24 months of follow-up, in terms of both the proportion of subjects with mutations and the total number of mutations., Conclusions: In this patient population, the mutational archive in HIV-1 DNA extracted from PBMC was stable for 24 months, irrespective of HAART modality, whether continuous or intermittent.

Published
2009
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