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Your search keyword '"Wareing, Mark"' showing total 13 results
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13 results on '"Wareing, Mark"'

1. Beetroot juice lowers blood pressure and improves endothelial function in pregnant eNOS −/− mice: importance of nitrate‐independent effects

Author

Tropea, Teresa, primary, Renshall, Lewis J., additional, Nihlen, Carina, additional, Weitzberg, Eddie, additional, Lundberg, Jon O., additional, David, Anna L., additional, Tsatsaris, Vassilis, additional, Stuckey, Daniel J., additional, Wareing, Mark, additional, Greenwood, Susan L., additional, Sibley, Colin P., additional, and Cottrell, Elizabeth C., additional

Published
2020
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5. Dysregulated flow-mediated vasodilatation in the human placenta in fetal growth restriction

Author

Jones, Sarah, Bischof, Helen, Lang, Ingrid, Desoye, Gernot, Greenwood, Susan, Johnstone, Edward, Wareing, Mark, Sibley, Colin, and Brownbill, Paul

Abstract

Increased vascular resistance and reduced fetoplacental blood flow are putative aetiologies in the pathogenesis of fetal growth restriction (FGR); however, the regulating sites and mechanisms remain unclear. We hypothesised that placental vessels dictate fetoplacental resistance and in FGR exhibit endothelial dysfunction and reduced flow-mediated vasodilatation (FMVD). Resistance was measured in normal pregnancies (n = 10) and FGR (n = 10) both in vivo by umbilical artery Doppler velocimetry and ex vivo by dual placental perfusion. Ex vivo FMVD is the reduction in fetal-side inflow hydrostatic pressure (FIHP) following increased flow rate. Results demonstrated a significant correlation between vascular resistance measured in vivo and ex vivo in normal pregnancy, but not in FGR. In perfused FGR placentas, vascular resistance was significantly elevated compared to normal placentas (58 ± 7.7 mmHg and 36.8 ± 4.5 mmHg, respectively; 8 ml min(-1) ; means ± SEM; P

Published
2015

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