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Your search keyword '"Wang, S. H."' showing total 39 results
Start Over Author "Wang, S. H." Publisher wiley
39 results on '"Wang, S. H."'

3. Describing the quality of life of boys with haemophilia in China: Results of a multicentre study using the CHO-KLAT

Author

Tang, L., primary, Xu, W., additional, Li, C. G., additional, Hou, F., additional, Feng, X. Q., additional, Wang, H., additional, Li, X. J., additional, Li, W. L., additional, Liu, J. P., additional, Sun, L. R., additional, Wang, S. H., additional, Jin, J., additional, Fang, Q., additional, Luke, K. H., additional, Poon, M. C., additional, Blanchette, V. S., additional, Usuba, K., additional, Young, N. L., additional, and Wu, R., additional

Published
2017
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4. Polygenic risk for schizophrenia and neurocognitive performance in patients with schizophrenia

Author

Wang, S.-H., primary, Hsiao, P.-C., additional, Yeh, L.-L., additional, Liu, C.-M., additional, Liu, C.-C., additional, Hwang, T.-J., additional, Hsieh, M. H., additional, Chien, Y.-L., additional, Lin, Y.-T., additional, Chandler, S. D., additional, Faraone, S. V., additional, Laird, N., additional, Neale, B., additional, McCarroll, S. A., additional, Glatt, S. J., additional, Tsuang, M. T., additional, Hwu, H.-G., additional, and Chen, W. J., additional

Published
2017
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27. Interlaboratory comparison of ultrasonic backscatter, attenuation, and speed measurements.

Author

Madsen, E L, primary, Dong, F, additional, Frank, G R, additional, Garra, B S, additional, Wear, K A, additional, Wilson, T, additional, Zagzebski, J A, additional, Miller, H L, additional, Shung, K K, additional, Wang, S H, additional, Feleppa, E J, additional, Liu, T, additional, O'Brien, W D, additional, Topp, K A, additional, Sanghvi, N T, additional, Zaitsev, A V, additional, Hall, T J, additional, Fowlkes, J B, additional, Kripfgans, O D, additional, and Miller, J G, additional

Published
1999
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37. Structure and topology of a peptide segment of the 6th transmembrane domain of the Saccharomyces cerevisae alpha-factor receptor in phospholipid bilayers.

Author

Valentine KG, Liu SF, Marassi FM, Veglia G, Opella SJ, Ding FX, Wang SH, Arshava B, Becker JM, and Naider F

Subjects
Amino Acid Sequence, Biopolymers chemistry, Biopolymers genetics, Lipid Bilayers, Magnetic Resonance Spectroscopy, Mating Factor, Models, Molecular, Molecular Sequence Data, Nitrogen Isotopes, Peptides chemistry, Phospholipids, Protein Structure, Tertiary, Receptors, Mating Factor, Receptors, Peptide genetics, Saccharomyces cerevisiae chemistry, Saccharomyces cerevisiae genetics, Spectroscopy, Fourier Transform Infrared, Receptors, Peptide chemistry, Transcription Factors
Abstract

A detailed analysis of the structure of an 18-residue peptide AQSLLVPSIIFILAYSLK [M6(252-269, C252A)] in 1,2-dimyristoyl-sn-glycero-phosphocholine bilayers was carried out using solid state NMR and attenuated total reflection Fourier transform infrared spectroscopy. The peptide corresponds to a portion of the 6th transmembrane domain of the alpha-factor receptor of Saccharomyces cerevisiae. Ten homologs of M6(252-269, C252A) were synthesized in which individual residues were labeled with (15)N. One- and two-dimensional solid state NMR experiments were used to determine the chemical shifts and (1)H-(15)N dipolar coupling constants for the (15)N-labeled peptides in oriented dimyristoylphosphatidylcholine bilayers on stacked glass plates. These parameters were used to calculate the structure and orientation of M6(252-269, C252A) in the bilayers. The results indicate that the carboxyl terminal residues (9-14) are alpha-helical and oriented with an angle of about 8 degrees with respect to the bilayer normal. Independently, an attenuated total reflection Fourier transform infrared spectroscopy analysis on M6(252-269, C252A) in a 1,2-dimyristoyl-sn-glycero-phosphocholine bilayer concluded that the helix tilt angle was about 12.5 degrees. The results on the structure of M6(252-269, C252A) in bilayers are in good agreement with the structure determined in trifluoroethanol/water solutions (B. Arshava et al. Biopolymers, 1998, Vol. 46, pp. 343-357). The present study shows that solid state NMR spectroscopy can provide high resolution information on the structure of transmembrane domains of a G protein-coupled receptor., (Copyright 2001 John Wiley & Sons, Inc. Biopolymers 59: 243-256, 2001)

Published
2001
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38. Differential cardiovascular responses to blockade of nNOS or iNOS in rostral ventrolateral medulla of the rat.

Author

Chan SH, Wang LL, Wang SH, and Chan JY

Subjects
Animals, Blood Pressure drug effects, Dose-Response Relationship, Drug, Enzyme Inhibitors pharmacology, Heart Rate drug effects, Indazoles pharmacology, Male, Medulla Oblongata enzymology, Medulla Oblongata physiology, Microinjections, Neurons drug effects, Neurons physiology, Nitric Oxide pharmacology, Nitric Oxide Synthase genetics, Nitric Oxide Synthase metabolism, Nitric Oxide Synthase Type I, Nitric Oxide Synthase Type II, Penicillamine analogs & derivatives, Penicillamine pharmacology, RNA, Messenger drug effects, RNA, Messenger metabolism, Rats, Rats, Sprague-Dawley, Benzoates pharmacology, Imidazoles pharmacology, Medulla Oblongata drug effects, Nitric Oxide Synthase analysis, Nitric Oxide Synthase antagonists & inhibitors
Abstract

We investigated the contribution of neuronal or inducible nitric oxide synthase (nNOS or iNOS) at the rostral ventrolateral medulla (RVLM) to central cardiovascular regulation by endogenous nitric oxide (NO), using Sprague-Dawley rats anaesthetized and maintained with propofol. Microinjection bilaterally into the RVLM of a NO trapping agent, carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-l-oxy-l-3-oxide (10, 50 or 100 nmoles) resulted in significant hypotension and bradycardia. Similar application of a selective antagonist of nNOS, 7-nitroindazole (1, 2.5 or 5 pmoles), or selective antagonists of iNOS, aminoguanidine (125, 250 or 500 pmoles), N(6)-(l-iminoethyl)-L-lysine (250 pmoles) or S-methylisothiourea (250 pmoles), induced respectively a reduction or an enhancement in systemic arterial pressure, heart rate and power density of the vasomotor components in the spectrum of arterial blood pressure signals, the experimental index for sympathetic neurogenic vasomotor tone. Both hypotension and bradycardia induced by the NO precursor, L-arginine (100 nmoles), were significantly blunted when aminoguanidine (250 pmoles) was co-microinjected bilaterally into the RVLM. On the other hand, co-administered 7-nitroindazole (2.5 pmoles) was ineffective. Whereas low doses of S-nitro-N-acetylpenicillamine (0.25 or 0.5 nmoles) elicited hypertension and tachycardia, high doses of this non-nitrate NO donor (5 nmoles) induced hypotension and bradycardia. Reverse transcription - polymerase chain reaction analysis revealed that both iNOS and nNOS mRNA were expressed in the ventrolateral medulla. We conclude that the prevalence of nNOS over iNOS activity at the RVLM and the associated dominance of sympathoexcitation over sympathoinhibition may underlie the maintenance of sympathetic vasomotor outflow and stable systemic arterial pressure by the endogenous NO.

Published
2001
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39. Chemical synthesis of the M-factor mating pheromone from Schizosaccharomyces pombe.

Author

Wang SH, Xue CB, Nielsen O, Davey J, and Naider F

Subjects
Amino Acid Sequence, DNA-Binding Proteins, Intercellular Signaling Peptides and Proteins, Molecular Sequence Data, Schizosaccharomyces growth & development, Peptides chemical synthesis, Pheromones chemical synthesis, Schizosaccharomyces chemistry, Schizosaccharomyces pombe Proteins
Abstract

Conjugation in the fission yeast Schizosaccharomyces pombe is controlled by the reciprocal action of mating pheromones. We recently showed that M-factor, the pheromone released by cells of the cellular mating type Minus, is a nonapeptide in which the C-terminal cysteine residue is carboxyl-methylated and S-alkylated, probably with a farnesyl residue (Davey, 1992): Tyr-Thr-Pro-Lys-Val-Pro-Tyr-Met-Cys(S-farnesyl)- OCH3. Here we describe the chemical synthesis of this modified peptide and show that it exhibits all of the properties of the native pheromone. These results confirm the structure of the M-factor while the production of relatively large amounts of pure pheromone will be invaluable for studying the mating response in this yeast.

Published
1994
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