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31 results on '"Wang, Qilong"'

3. Phenolic acids from Prunella vulgaris alleviate cardiac remodeling following myocardial infarction partially by suppressing NLRP3 activation

Author

Wei, Jinna, primary, Leng, Ling, additional, Sui, Yunchan, additional, Song, Shaofei, additional, Owusu, Felix Boahen, additional, Li, Xue, additional, Cao, Yu, additional, Li, Peijie, additional, Wang, Hongda, additional, Li, Ruiqiao, additional, Yang, Wenzhi, additional, Gao, Xiumei, additional, and Wang, Qilong, additional

Published
2023
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14. Novel enhanced GFP‐positive congenic inbred strain establishment and application of tumor‐bearing nude mouse model

Author

Lan, Qing, primary, Chen, Yanming, additional, Dai, Chungang, additional, Li, Shenggang, additional, Fei, Xifeng, additional, Dong, Jun, additional, Shen, Yanhua, additional, Dai, Xingliang, additional, Lu, Zhaohui, additional, Liu, Bing, additional, Wang, Qilong, additional, Wang, Haiyang, additional, Zhou, Zhengyu, additional, Ji, Xiaoyan, additional, Wang, Zhimin, additional, and Huang, Qiang, additional

Published
2020
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18. Enhanced photoelectric and photothermal responses on silicon platform by plasmonic absorber and omni-schottky junction

Author

Wen, Long, Chen, Yifu, Liu, Wanwan, Su, Qiang, Grant, James, Qi, Zhiyang, Wang, Qilong, and Chen, Qin

Abstract

Recent progresses in plasmon-induced hot electrons open up the possibility to achieve photon harvesting beyond the fundamental limit imposed by band-to-band transitions in semiconductors. To obtain high efficiency, both the optical absorption and electron emission/collection are crucial factors that need to be addressed in the design of hot electron devices. Here, we demonstrate a photoresponse as high as 3.3mA/W at 1500nm on a silicon platform by plasmonic absorber (PA) and omni-Schottky junction integrated photodetector, reverse biased at 5V and illuminated with 10mW. The PA fabricated on silicon consists of a monolayer of random Au nanoparticles (NPs), a wide-band gap semiconductor (TiO2) and an optically thick Au electrode, resulting in broadband near-infrared (NIR) absorption and efficient hot-electron transfer via an all-around Schottky emission path. Meanwhile, time and spectral-resolved photoresponse measurements reveal that embedded NPs with superior absorption resembling plasmonic local heating sources can transfer their energy to electricity via the photothermal mechanism, which until now has not been adequately assessed or rigorously differentiated from the photoelectric process in plasmon-mediated photon harvesting nano-systems.

Published
2017

23. ChemInform Abstract: Acetoxybenzhydrols as Highly Active and Stable Analogues of 1′S-1′-Acetoxychavicol, a Potent Antiallergic Principal from Alpinia galanga

Author

Wang Qilong, Hisashi Matsuda, Takayuki Morimoto, Tomohisa Yasuhara, Osamu Muraoka, Masayuki Yoshikawa, and Yoshiaki Manse

Subjects
chemistry.chemical_compound, food.ingredient, food, Chemistry, Phenyl acetate, Stereochemistry, Alpinia galanga, Degranulation, General Medicine
Abstract

Through SAR studies on 1'S-1'-acetoxychavicol acetate (1) against Type I antiallergic activity by indexing release of beta-hexosaminidase, a marker of antigen-IgE-mediated degranulation in RBL-2H3 cells, more stable and potent analogue, 4-(methoxycarbonyloxyphenylmethyl)phenyl acetate (16), has been developed. The compound 16 also strongly inhibited the antigen-IgE-mediated TNF-alpha and IL-4 production.

Published
2009

30. Phenolic acids from Prunella vulgaris alleviate cardiac remodeling following myocardial infarction partially by suppressing NLRP3 activation.

Author

Wei J, Leng L, Sui Y, Song S, Owusu FB, Li X, Cao Y, Li P, Wang H, Li R, Yang W, Gao X, and Wang Q

Subjects
Rats, Animals, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, Ventricular Remodeling, Myocytes, Cardiac, Fibrosis, Caffeic Acids pharmacology, Prunella metabolism, Myocardial Infarction drug therapy
Abstract

Acute myocardial infarction (MI) is one of the leading causes of mortality around the world. Prunella vulgaris (Xia-Ku-Cao in Chinese) is used in traditional Chinese medicine practice for the treatment of cardiovascular diseases. However, its active ingredients and mechanisms of action on cardiac remodeling following MI remain unknown. In this study, we investigated the cardioprotective effect of P. vulgaris on MI rat models. MI rats were treated with aqueous extract of P. vulgaris or phenolic acids from P. vulgaris, including caffeic acid, ursolic acid or rosmarinic acid, 1 day after surgery and continued for the following 28 days. Then the cardioprotective effect, such as cardiac function, inflammatory status, and fibrosis areas were evaluated. RNA-sequencing (RNA-seq) analysis, real-time polymerase chain reaction (PCR), western blotting, and ELISA were used to explore the underlying mechanism. In addition, ultra-high performance liquid chromatography/mass spectrometer analysis was used to identify the chemicals from P. vulgaris. THP-1 NLRP3-GFP cells were used to confirm the inhibitory effect of P. vulgaris and phenolic acids on the expression and activity of NLRP3. We found that P. vulgaris significantly improved cardiac function and reduced infarct size. Meanwhile, P. vulgaris protected cardiomyocyte against apoptosis, evidenced by increasing the expression of anti-apoptosis protein Bcl-2 in the heart and decreasing lactate dehydrogenase (LDH) levels in serum. Results from RNA-seq revealed that the therapeutic effect of P. vulgaris might relate to NLRP3-mediated inflammatory response. Results from real-time PCR and western blotting confirmed that P. vulgaris suppressed NLRP3 expression in MI heart. We also found that P. vulgaris suppressed NLRP3 expression and the secretion of HMGB1, IL-1β, and IL-18 in THP-1 NLRP3-GFP cells. Further studies indicated that the active components of P. vulgaris were three phenolic acids, those were caffeic acid, ursolic acid, and rosmarinic acid. These phenolic acids inhibited LPS-induced NLRP3 expression and activity in THP-1 cells, and improved cardiac function, suppressed inflammatory aggregation and fibrosis in MI rat models. In conclusion, our study demonstrated that P. vulgaris and phenolic acids from P. vulgaris, including caffeic acid, ursolic acid, and rosmarinic acid, could improve cardiac function and protect cardiomyocytes from ischemia injury during MI. The mechanism was partially related to inhibiting NLRP3 activation., (© 2023 John Wiley & Sons Ltd.)

Published
2024
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31. Preparation, characterization, pharmacokinetics, and antirenal injury activity studies of Licochalcone A-loaded liposomes.

Author

Liu J, Zhu Z, Yang Y, Adu-Frimpong M, Chen L, Ji H, Toreniyazov E, Wang Q, Yu J, and Xu X

Subjects
Animals, Biological Availability, Mice, Solubility, Chalcones pharmacology, Liposomes chemistry
Abstract

A liposome of Licochalcone A (LCA-Liposomes) was purposively prepared to ameliorate the low in vivo availability and efficacy of LCA. Physical characterization of LCA-Liposomes was carried out mainly by determining particle size, morphology, zeta potential (Z-potential), and efficiency of LCA encapsulation (EE) via appropriate techniques. Also, the rate of LCA release in vitro and distribution in vivo (plasma and tissues) was evaluated. Evaluation of the antirenal activity of LCA-liposomes was carried out by establishing chronic renal failure (CRF) model in mice through intragastric administration of adenine (200 mg/kg) and subsequent determination of biochemical parameters and examination of tissue sections. Respectively, the mean size of liposomal particles, Z-potential and EE of LCA-Liposomes were 71.78 ± 0.99 nm, -38.49 ± 0.06 mV, and 97.67 ± 1.72%. Pharmacokinetic and tissue distribution studies showed that LCA-Liposomes could improve the availability of LCA in the blood and tissues, whereas during pharmacodynamics studies, the liposome effectively improved the therapeutic effect of LCA on CRF mice by potentially protecting the renal tissues while exhibiting antioxidant activity. In conclusion, LCA-Liposomes could effectively improve the bioavailability of LCA and provide platform for the development of LCA-related functional products. PRACTICAL APPLICATIONS: As a traditional Chinese medicine, licorice is widely used in food and pharmaceutical industries. LCA is a small molecule flavonoid extracted from the root of licorice. In this study, LCA was loaded on liposome carriers, which significantly improved the water solubility and oral bioavailability, and proved that LCA-Liposomes have certain therapeutic effects on chronic renal failure, thereby providing a basis for the development of LCA into drugs or functional food in the future., (© 2021 Wiley Periodicals LLC.)

Published
2022
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