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C-H Functionalization is ubiquitously considered as a powerful, efficient and handy tool for installing various functional groups in complex organic heterocycles in an easier and step-economic way. Similarly, indazole is endowed as a potent heterocycle and is eminent for its profound impact in biological, medicinal and industrial chemistry. In this scenario, C-H functionalization at the selective ortho position of 2-arylindazole in assistance of a metal catalyst is also becoming an appealing approach in synthetic organic chemistry. This review addressed the recent findings and developments on ortho C-H functionalization of 2-aryl-2H-indazazoles with literature coverage extending from 2018 to May 2022., (© 2022 The Chemical Society of Japan & Wiley-VCH GmbH.)

Enantiomerically enriched five- and six-membered benzo oxygen heterocycles are privileged architectures in functional organic molecules. Over the last several years, many effective methods have been established to access these compounds. However, comprehensive documents cover updated methodologies still in highly demand. In this review, recent transition metal catalyzed transformations lead to chiral five- and six-membered benzo oxygen heterocycles are presented. The mechanism and chirality transfer or control processes are also discussed in details., (© 2023 The Chemical Society of Japan & Wiley-VCH GmbH.)

Transition-metal-catalyzed direct transformation of inert C-H bond has revolutionized the arsenal of main-stream organic synthesis, providing a new upfront to forge structurally enriched and biologically relevant scaffolds in a step- and atom-economical way. Past decades have accounted for the major developments in this realm, proclaiming excellent site-selectivity by exploiting a variety of coordinating directing groups (DGs). Consideration of versatile, abundant, sp 3 -hybridized free-amine (-NH 2 ) functionality for the same purpose has always been a formidable task owing to its innate reactivity. In recent years, free-amine functionality has emerged as a potent DG for a wide range of C-C and C-heteroatom bonds formations and annulation cascades. In this review article, we have discussed the advancements of free-amine directed C-H activation/functionalization reactions towards biaryl frameworks made within a decade (2012 to 2021)., (© 2021 The Chemical Society of Japan & Wiley-VCH GmbH.)