Search

Your search keyword '"Vassilev V"' showing total 23 results
Start Over Author "Vassilev V" Publisher wiley
23 results on '"Vassilev V"'

23. Primary sequence confirmation of the beta-amyloid peptide from hereditary cerebral haemorrhage with amyloidosis (Dutch type) by collisional activation of the doubly charged ion.

Author

Orlando R and Vassilev VP

Subjects
Amino Acid Sequence, Cerebral Hemorrhage genetics, Humans, Mass Spectrometry, Molecular Sequence Data, Amyloid beta-Peptides analysis, Amyloidosis metabolism, Cerebral Hemorrhage metabolism
Abstract

High-energy collisional activation of doubly charged peptide ions allows direct sequential analysis of peptides over 4 kDa, including leucine/isoleucine determinations. This technique was used to verify the sequence of an intact beta-amyloid peptide associated with hereditary cerebral haemorrhage with amyloidosis Dutch type (4.2 kDa), which resists both enzymatic digestion and Edman sequencing. Additionally, this approach shows promise for the primary sequence confirmation of a wide variety of large peptides by tandem mass spectrometry.

Published
1992
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results