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31 results on '"Uygun, Vedat"'

1. COVID‐19 disease in children and adolescents following allogeneic hematopoietic stem cell transplantation: A report from the Turkish pediatric bone marrow transplantation study group

Author

Bozkurt, Ceyhun, primary, Hazar, Volkan, additional, Malbora, Barış, additional, Küpesiz, Alphan, additional, Aygüneş, Utku, additional, Fışgın, Tunç, additional, Karakükçü, Musa, additional, Kuşkonmaz, Barış, additional, Kılıç, Suar Çakı, additional, Bayırlı, Derya, additional, Arman Bilir, Özlem, additional, Yalçın, Koray, additional, Gözmen, Salih, additional, Uygun, Vedat, additional, Elli, Murat, additional, Sarbay, Hakan, additional, Küpesiz, Funda Tayfun, additional, Şaşmaz, Hatice İlgen, additional, Aksoy, Başak Adaklı, additional, Yılmaz, Ebru, additional, Okur, Fatma Visal, additional, Tekkeşin, Funda, additional, Yenigürbüz, Fatma Demir, additional, Özek, Gülcihan, additional, Atay, Abdullah Avni, additional, Bozkaya, İkbal Ok, additional, Çelen, Suna, additional, Öztürkmen, Seda, additional, Güneş, Adalet Meral, additional, Gürsel, Orhan, additional, Güler, Elif, additional, Özcan, Alper, additional, Çetinkaya, Duygu Uçkan, additional, Aydoğdu, Selime, additional, Özbek, Namık Yaşar, additional, Karasu, Gülsün, additional, Sezgin, Gülay, additional, Doğru, Ömer, additional, Albayrak, Davut, additional, Öztürk, Gülyüz, additional, Aksoylar, Serap, additional, Daloğlu, Hayriye, additional, Odaman Al, Işık, additional, Evim, Melike Sezgin, additional, Akbayram, Sinan, additional, Öncül, Yurday, additional, Zengin, Emine, additional, Albayrak, Canan, additional, Timur, Çetin, additional, Kar, Yeter Düzenli, additional, Çakmaklı, Hasan Fatih, additional, Tüfekçi, Özlem, additional, Töret, Ersin, additional, and Antmen, Bülent, additional

Published
2024
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2. Pre‐transplantation vitamin D deficiency increases acute graft‐versus‐host disease after hematopoietic stem cell transplantation in thalassemia major patients

Author

Daloğlu, Hayriye, Uygun, Vedat, Ozturkmen, Seda, Yalcın, Koray, Karasu, Gulsu, Yesilipek, Akif, İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Uygun, Vedat, and AGH-4534-2022

Subjects
Transplantation, Acute Graft Versus Host Disease, Hematopoetic Stem Cell Transplantation, Vitamin D, Children, Thalassemia Major
Abstract

Background: Although there are many studies on the role of vitamin D deficiency (VDD) in hematopoetic stem cell transplantation (HSCT), outcomes have often reported conflicting results because of the heterogeneity of the patients in the studies. Methods: We investigated the association between VDD prior to HSCT and outcomes after HSCT in a relatively homogenous group of patients with thalassemia major (TM) who received identical treatment for TM before transplantation, and the same conditioning regimen and GVHD prophylaxis during and after transplantation. All patients, including the patients with normal vitamin D3 levels received 400 to 800 IU per day of vitamin D for the first 6 months after HSCT. Results: Pre-HSCT VDD increased the frequency of aGVHD after transplantation, particularly in HSCTs performed with PBSC for the stem cell source. Pre-transplant low vitamin D3 levels had no association with transplant outcomes such as engraftment, viral infections, alloimmunization, chronic GvHD, total days of hospitalization, and success in terms of transfusion independence. Conclusions: Low vitamin D3 levels before HSCT carry a significant risk for aGVHD. All patients with TM should be screened for VDD before HSCT, and every effort should be made to supplement vitamin D before the transplant in VDD patients 36461145

Published
2022
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5. Allogeneic hematopoietic stem cell transplantation in patients with childhood cerebral adrenoleukodystrophy: A single‐center experience “Better prognosis in earlier stage”

Author

Yalcin, Koray, primary, Çelen, Suna S., additional, Daloglu, Hayriye, additional, Demir, Mustafa Kemal, additional, Öztürkmen, Seda, additional, Pasayev, Dayanat, additional, Zhumatayev, Suleimen, additional, Uygun, Vedat, additional, Hazar, Volkan, additional, Karasu, Gulsun, additional, and Yesilipek, Akif, additional

Published
2021
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8. Hematopoietic stem cell transplantation in CD40 ligand deficiency: A single‐center experience

Author

Uygun, Dilara Fatma Kocacık, primary, Uygun, Vedat, additional, Karasu, Gülsün Tezcan, additional, Daloğlu, Hayriye, additional, Öztürkmen, Seda Irmak, additional, Çelmeli, Fatih, additional, Törün, Selda Hançerli, additional, Özen, Ahmet, additional, Barış, Safa, additional, Aydıner, Elif Karakoç, additional, Yalçın, Koray, additional, Kılıç, Suar Çakı, additional, Hazar, Volkan, additional, Bingöl, Ayşen, additional, and Yeşilipek, Akif, additional

Published
2020
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9. Mutational landscape of severe combined immunodeficiency patients from Turkey

Author

Firtina, Sinem, primary, Yin Ng, Yuk, additional, Hatirnaz Ng, Ozden, additional, Kiykim, Ayca, additional, Aydiner, Elif, additional, Nepesov, Serdar, additional, Camcioglu, Yildiz, additional, Sayar, Esra H., additional, Reisli, Ismail, additional, Torun, Selda H., additional, Cogurlu, Tuba, additional, Uygun, Dilara, additional, Simsek, Isil E., additional, Kaya, Aysenur, additional, Cipe, Funda, additional, Cagdas, Deniz, additional, Yucel, Esra, additional, Cekic, Sukru, additional, Uygun, Vedat, additional, Baris, Safa, additional, Ozen, Ahmet, additional, Ozbek, Ugur, additional, and Sayitoglu, Muge, additional

Published
2020
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11. ILC3 deficiency and generalized ILC abnormalities in DOCK8‐deficient patients

Author

Eken, Ahmet, primary, Cansever, Murat, additional, Okus, Fatma Zehra, additional, Erdem, Serife, additional, Nain, Ercan, additional, Azizoglu, Zehra Busra, additional, Haliloglu, Yesim, additional, Karakukcu, Musa, additional, Ozcan, Alper, additional, Devecioglu, Omer, additional, Aksu, Guzide, additional, Arikan Ayyildiz, Zeynep, additional, Topal, Erdem, additional, Karakoc Aydiner, Elif, additional, Kiykim, Ayca, additional, Metin, Ayse, additional, Cipe, Funda, additional, Kaya, Aysenur, additional, Artac, Hasibe, additional, Reisli, Ismail, additional, Guner, Sukru N., additional, Uygun, Vedat, additional, Karasu, Gulsun, additional, Dönmez Altuntas, Hamiyet, additional, Canatan, Halit, additional, Oukka, Mohamed, additional, Ozen, Ahmet, additional, Chatila, Talal A., additional, Keles, Sevgi, additional, Baris, Safa, additional, Unal, Ekrem, additional, and Patiroglu, Turkan, additional

Published
2019
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12. Homozygous c.130–131 ins A (pW44X) mutation in the HAX1 gene as the most common cause of congenital neutropenia in Turkey: Report from the Turkish Severe Congenital Neutropenia Registry

Author

Yılmaz Karapınar, Deniz, primary, Patıroğlu, Türkan, additional, Metin, Ayşe, additional, Çalışkan, Ümran, additional, Celkan, Tiraje, additional, Yılmaz, Barış, additional, Karakaş, Zeynep, additional, Karapınar, Tuba H., additional, Akıncı, Burcu, additional, Özkınay, Ferda, additional, Onay, Hüseyin, additional, Yeşilipek, Mehmet Akif, additional, Akar, Himmet Haluk, additional, Tüysüz, Gülen, additional, Tokgöz, Hüseyin, additional, Özdemir, Gül Nihal, additional, Aslan Kıykım, Ayça, additional, Karaman, Serap, additional, Kılınç, Yurdanur, additional, Oymak, Yeşim, additional, Küpesiz, Alphan, additional, Olcay, Lale, additional, Keskin Yıldırım, Zuhal, additional, Aydoğan, Gönül, additional, Gökçe, Müge, additional, İleri, Talia, additional, Aral, Yusuf Ziya, additional, Bay, Ali, additional, Atabay, Berna, additional, Kaya, Zuhre, additional, Söker, Murat, additional, Özdemir Karadaş, Nihal, additional, Özbek, Uğur, additional, Özsait Selçuk, Bilge, additional, Özdemir, Hamiyet Hekimci, additional, Uygun, Vedat, additional, Tezcan Karasu, Gülsün, additional, and Yılmaz, Şebnem, additional

Published
2019
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14. Deferasirox in children with transfusion‐dependent thalassemia or sickle cell anemia: A large cohort real‐life experience from Turkey (REACH‐THEM)

Author

Antmen, Bulent, primary, Karakaş, Zeynep, additional, Yeşilipek, Mehmet Akif, additional, Küpesiz, Osman Alphan, additional, Şaşmaz, İlgen, additional, Uygun, Vedat, additional, Kurtoğlu, Erdal, additional, Oktay, Gonul, additional, Aydogan, Gonul, additional, Akın, Mehmet, additional, Salcioglu, Zafer, additional, Vergin, Canan, additional, Kazancı, Elif Güler, additional, Ünal, Selma, additional, Çalışkan, Ümran, additional, Aral, Yusuf Ziya, additional, Türkkan, Emine, additional, Meral Güneş, Adalet, additional, Tunç, Bahattin, additional, Gümrük, Fatma, additional, Ayhan, Aylin Canbolat, additional, Söker, Murat, additional, Koç, Ahmet, additional, Oymak, Yeşim, additional, Ertem, Mehmet, additional, Timur, Çetin, additional, Yıldırmak, Yıldız, additional, İrken, Gülersu, additional, Apak, Hilmi, additional, Biner, Betül, additional, Eren, Tuğba Gürleyen, additional, Işık Balcı, Yasemin, additional, Koçak, Ülker, additional, Karasu, Gülsün, additional, Akkaynak, Diyar, additional, and Patıroğlu, Türkan, additional

Published
2018
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17. Hematopoietic stem cell transplantation from unrelated donors in children with DOCK8 deficiency

Author

Uygun, Dilara Fatma K., primary, Uygun, Vedat, additional, Reisli, İsmail, additional, Keleş, Sevgi, additional, Özen, Ahmet, additional, Yılmaz, Mustafa, additional, Sayar, Esra H., additional, Daloğlu, Hayriye, additional, Öztürkmen, Seda I., additional, Çakı, Suar, additional, Karasu, Gülsün T., additional, and Yeşilipek, Akif, additional

Published
2017
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30. Hematopoietic stem cell transplantation in serine/threonine kinase 4 (STK4) deficiency: Report of two cases and literature review

Author

Vedat Uygun, Sevgi Keleş, Hayriye Daloğlu, Seda Öztürkmen, Koray Yalçın, Gülsün Karasu, Akif Yeşilipek, İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Uygun, Vedat, and AGH-4534-2022

Subjects
STK4 Deficiency, Transplantation, Pediatrics, Perinatology and Child Health, Hematopoietic Stem Cell Transplantation, Children
Abstract

Background Serine/threonine kinase 4 (STK4) deficiency is a combined immunodeficiency (CID) characterized by early onset recurrent bacterial, viral, and fungal infections. Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative therapy for CID; however, little is known about the necessity and benefits of HSCT in patients with STK4 deficiency. Methods We report two siblings with STK4 deficiency transplanted from two unrelated donors with the same conditioning regimen. Results In the conditioning regimen, rituximab was given on Day -11 (375 mg/m(2)), and sirolimus was added on the same day. Busulfan was administered at a myeloablative dose (3.2 mg/kg; Days -7 to -4) with 150 mg/m(2) of fludarabine (Days -7 to -3). They were transplanted with peripheral blood stem cells, and graft-versus-host disease (GVHD) prophylaxis was administered with 10 mg/m(2) methotrexate on Days 1, 3, and 6. In addition, mycophenolate mofetil (MMF) was started on Day 1 with ongoing use of sirolimus. We did not encounter veno-occlusive disease (VOD), high-grade acute GVHD, or significant organ toxicity in either patient. Both patients were well at the end of the first year after HSCT with complete donor chimerism. Conclusions Serine/threonine kinase 4 deficiency is a disease with high mortality post-HSCT; therefore, the conditioning regimen and GVHD prophylaxis strategies are important considerations in these patients. In our opinion, the conditioning regimen, which includes rituximab and busulfan and fludarabine (BU-FLU), GVHD prophylaxis with sirolimus and MMF, and short-term methotrexate, offers favorable outcomes and is well tolerated in our STK4-deficient patients. WOS:000884588000001 Q4

Published
2022
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31. Cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis in a child with interleukin-12 receptor beta-1 deficiency.

Author

Filiz S, Kocacik Uygun DF, Verhard EM, van Dissel JT, Uygun V, Bassorgun C, Bingol A, Yegin O, and van de Vosse E

Subjects
Anti-Bacterial Agents therapeutic use, Biopsy, Ceftriaxone therapeutic use, Child, Preschool, Female, Genetic Predisposition to Disease, Humans, Vasculitis, Leukocytoclastic, Cutaneous drug therapy, Vasculitis, Leukocytoclastic, Cutaneous genetics, Receptors, Interleukin-12 deficiency, Salmonella enteritidis isolation & purification, Vasculitis, Leukocytoclastic, Cutaneous microbiology
Abstract

Defects in the interleukin 12 (IL-12)/interferon gamma (IFN-γ) pathway result in Mendelian susceptibility to mycobacterial disease (MSMD). IL-12 receptor beta 1 (IL-12Rβ1) deficiency, the most common form of MSMD, is associated with weakly virulent mycobacteria and salmonella. Infections in patients with this deficiency are extraintestinal, or septicemic, recurrent infections with nontyphoid salmonellae. Here we report a case of an IL-12Rβ1 deficiency with cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis., (© 2012 Wiley Periodicals, Inc.)

Published
2014
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