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Although we are witnessing a new phase in the management of COVID-19, understanding what predicts adherence to preventive behaviors still remains crucial. In this study we focus on interpersonal relationships by specifically investigating whether engagement in preventive behaviors when in the presence of others may be a function of the type of relationship (in terms of closeness) one has with others. Because close others are often perceived similar to the self compared to strangers, we put forward that close relationships may inadvertently decrease COVID-19 risk perceptions which may ultimately decrease compliance with recommended behaviors when in their presence. To test this hypothesis, 747 Italian respondents were invited to answer one out of four versions of a questionnaire differing on the target (i.e., friends vs. parents vs. grandparents vs. strangers), including questions regarding COVID-19 risk perceptions and intentions to engage in preventive behaviors. Mediation analysis showed that close relationships (i.e., with friends, parents, and grandparents) compared to nonclose relationships (i.e., with strangers) predicted lower intentions to engage in preventive behaviors via lower risk perceptions. Altogether, these results shed light on the role played by closeness in indirectly shaping individuals' dis(engagement) in preventive behaviors and contribute to better understand possible unconscious biases which may undermine our safety during the COVID-19 pandemic.

Patients with high-risk prostate cancer (HRPC) have multiple accepted treatment options. Because there is no overall survival benefit of one option over another, appropriate treatment must consider patient life expectancy, quality of life, and cost.The authors compared quality-adjusted life years (QALYs) and cost effectiveness among treatment options for HRPC using a Markov model with three treatment arms: (1) external-beam radiotherapy (EBRT) delivered with 20 fractions, (2) EBRT with 23 fractions followed by low-dose-rate (LDR) brachytherapy boost, or (3) radical prostatectomy alone. An exploratory analysis considered a simultaneous integrated boost according to the FLAME trial (ClinicalTrials.gov identifier NCT01168479).Treatment strategies were compared using the incremental cost-effectiveness ratio (ICER). EBRT with LDR brachytherapy boost was a cost-effective strategy (ICER, $20,929 per QALY gained). These results were most sensitive to variations in the biochemical failure rate. However, the results still demonstrated cost effectiveness for the brachytherapy boost paradigm, regardless of any tested parameter ranges. Probabilistic sensitivity analysis demonstrated that EBRT with LDR brachytherapy was favored in 52% of 100,000 Monte Carlo iterations. In an exploratory analysis, EBRT with a simultaneous integrated boost was also a cost-effective strategy, resulting in an ICER of $62,607 per QALY gained; however, it was not cost effective compared with EBRT plus LDR brachytherapy boost.EBRT with LDR brachytherapy boost may be a cost-effective treatment strategy compared with EBRT alone and radical prostatectomy for HRPC, demonstrating high-value care. The current analysis suggests that a reduction in biochemical failure alone can result in cost-effective care, despite no change in overall survival.

To reduce the likelihood of errors in organ delineations used for radiotherapy treatment planning, a knowledge-based quality control (KBQC) system, which discriminates between valid and anomalous delineations is developed.The KBQC is comprised of a group-wise inference system and anomaly detection modules trained using historical priors from 296 locally advanced lung and prostate cancer patient computational tomographies (CTs). The inference system discriminates different organs based on shape, relational, and intensity features. For a given delineated image set, the inference system solves a combinatorial optimization problem that results in an organ group whose relational features follow those of the training set considering the posterior probabilities obtained from support vector machine (SVM), discriminant subspace ensemble (DSE), and artificial neural network (ANN) classifiers. These classifiers are trained on nonrelational features with a 10-fold cross-validation scheme. The anomaly detection module is a bank of ANN autoencoders, each corresponding with an organ, trained on nonrelational features. A heuristic rule detects anomalous organs that exceed predefined organ-specific tolerances for the feature reconstruction error and the classifier's posterior probabilities. Independent data sets with anomalous delineations were used to test the overall performance of the KBQC system. The anomalous delineations were manually manipulated, computer-generated, or propagated based on a transformation obtained by imperfect registrations. Both peer-review-based scoring system and shape similarity coefficient (DSC) were used to label regions of interest (ROIs) as normal or anomalous in two independent test cohorts.The accuracy of the classifiers wasThe KBQC system detected anomalous delineations with superior accuracy compared to classification methods that judge only based on posterior probabilities.

Patients with renal cell carcinoma (RCC) brain metastases are frequently treated with immune checkpoint inhibitors (ICIs) and stereotactic radiosurgery (SRS). However, data reporting on the risk of developing radiation necrosis (RN) are limited.RN rates were compared for concurrent therapy (ICI/SRS administration within 4 weeks of one another) and nonconcurrent therapy with the χFifty patients (23 concurrent and 27 nonconcurrent) with 395 brain metastases were analyzed. The median follow-up was 12.1 months; the median age was 65 years. The median margin dose was 20 Gy, and 4% underwent prior whole-brain radiation therapy (WBRT). The median treated tumor volume was 3.32 cmSymptomatic RN occurs in a minority of patients with RCC brain metastases treated with ICI/SRS. The majority of events were grade 1 to 3 and were managed medically. Concurrent ICI/SRS does not appear to increase this risk. Attempts to improve dose conformality (reduce V12) may be the most successful mitigation strategy in single-fraction SRS.

The objectives of this study were to characterize the risk of death (1) from the primary cancer vs competing cause of death; and (2) from various causes of death vs the general poplation. The relative risk of death after a pediatric cancer diagnosis versus the general population and the risk of death from a primary cancer diagnosis versus competing causes of death.This retrospective, population-based study used the Surveillance, Epidemiology, and End Results database (1980-2015) and included patients aged 0 to 19 years at the time of diagnosis. Observed deaths were calculated; the risk of death versus the general population was assessed with standardized mortality ratios (SMRs). Competing risk models for the cause of death were performed.There were 58,356 patients who were diagnosed, and the mortality rate was 22.8%. To assess causes of death, 6996 patients who died during the study period were included (45,580 total person-years at risk): 5128 (73%) died of their primary cancer, and 1868 (27%) died of a competing cause. Among all patients, the rate of death from the index cancer was higher than the rate of death from another cause within the first 5 years after diagnosis. The risk of death from a nonprimary cancer began to supersede the rate of death from the primary cancer 10 years after diagnosis for patients with germ cell tumors, lymphomas, and sarcomas. SMRs for the primary cancer were highest within the first 5 years after diagnosis for all cancers (SMRs, 100-50,000; P .0001). The risk of death from competing causes (heart disease, suicide, and sepsis) was elevated (SMR,100; P .001). The risk of dying of heart disease was high, especially for patients with astrocytomas (SMR, 47.84; 95% confidence interval [CI], 27.87-76.59) and neuroblastomas (SMR, 98.59; 95% CI, 47.28-181.32). The risk of dying of suicide was high in most patients, particularly for those with osteosarcomas (SMR, 111.40; 95% CI, 2.82-620.69), Hodgkin lymphomas (SMR, 62.35; 95% CI, 34.89-102.83), and gonadal germ cell tumors (SMR, 28.97; 95% CI, 12.51-57.09).The cause of death for patients with gonadal germ cell tumors, lymphomas, and sarcomas is more commonly a secondary cancer or noncancerous cause than the primary disease; their risk of death from competing causes (heart disease, suicide, and sepsis) rises throughout life.

Purpose Leverage the National Cancer Database (NCDB) to evaluate trends in management of nonmetastatic squamous cell cancer (SCC) of the rectum and their effect on survival for this uncommon tumor. Methods and Materials Retrospective data was obtained from the NCDB for patients diagnosed with SCC of the rectum between 2004 and 2014, including cT1‐4, cN0‐2, cM0 tumors (cohort A, n = 2296). A subgroup analysis was performed on locally advanced tumors (cT1‐T2, N+ or cT3, N any, subcohort B, n = 883), treated with chemoradiation (n = 706) or trimodality therapy (n = 177) including chemotherapy, radiation, and surgery. Pathological complete response rate following neoadjuvant therapy was obtained. Univariate and multivariate logistic regression analyses were performed to generate hazard ratios (HR) investigating factors associated with overall survival. Kaplan‐Meier (K‐M) method was used to estimate overall surviving proportion at 5 and 10 years. Results The K‐M estimated 5 and 10 year overall survival for stage I disease was 71.3% and 57.8%, respectively; stage II disease was 57.0% and 38.9%, respectively; stage III disease was 57.8% and 41.5%, respectively. On multivariate analysis, higher cT category (P

Dye-sensitized solar cells (DSSCs) that use an aqueous (40 % w/w water content) choline chloride based deep eutectic solvent as an electrolyte medium have been investigated. The joint combination of the eutectic mixture and an appropriate hydrophilic sensitizer afforded a DSSC with a power conversion efficiency comparable to that using the same electrolyte composition but with conventional, toxic, and volatile solvents as the medium, which thereby paves the way to a new generation of eco-friendly, nature-inspired, low-cost solar devices.

We conducted a longitudinal study to test whether, in addition to being predicted by personality, intergroup contact is longitudinally associated with personality traits. Participants were 388 majority (Italian) and 109 minority (immigrant) first-year high school students. Results revealed a bidirectional relationship between contact and personality: Quality of contact was longitudinally associated with greater agreeableness and openness to experience, whereas agreeableness and openness to experience were longitudinal predictors of contact quality. An unexpected negative longitudinal association also emerged between quantity of contact and agreeableness. These effects were not moderated by group of belonging (majority vs. minority). Our findings highlight the importance of integrating research on intergroup contact with research on personality.

Summary A new class of template attacks aiming at recovering the secret key of a cryptographic core from measurements of its static power consumption is presented in this paper. These attacks exploit the dependence of the static current of Complementary metal–oxide–semiconductor Integrated Circuits on the input vector and the maximum likelihood decision rule as a statistical distinguisher. In the proposed Template Attacks Exploiting Static Power (TAESP), we take advantage of the temperature dependence of static currents in order to build a new multivariate approach able to extract relevant information from cryptographic devices. As a validation case study, we consider the PRESENT-80 block cypher algorithm and its implementation on a 40 nm Complementary metal–oxide–semiconductor process. Monte Carlo and corner simulations at transistor level are used to show the effectiveness of the TAESP in the presence of die-to-die and intra-die process variations. A real attack scenario is then built by adding Gaussian noise to current samples extracted from transistor-level simulations. The univariate TAESP in which just one temperature is considered to build the templates is compared against the multivariate TAESP in which measurements at different controlled temperatures are exploited. This comparison shows that using just a few different temperatures to build multivariate templates allows to strongly increase the effectiveness of the attack. Copyright © 2016 John Wiley & Sons, Ltd.

A correlational study investigated extended contact as a strategy to improve outgroup attitudes and stereotyping and to prepare children for future contact. Additional aims were to investigate when and why the effects of extended contact occur. In particular, intergroup empathy was tested as a mediator and direct contact (i.e. cross-group friendship) as a moderator of extended contact. Participants were Italian and immigrant elementary school children. Results showed that extended contact was associated with improved intergroup empathy, which, in turn, was associated with more positive outgroup attitudes, stereotypes and behavioural intentions. These effects were significant only among participants with a low or moderate level of direct contact. The theoretical and practical implications of findings are discussed. Copyright © 2016 John Wiley & Sons, Ltd.

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects and toxicity of particle and photon adjuvant radiotherapy (RT) in people with biopsy confirmed chordoma.

Summary A continuous-time complementary metal–oxide–semiconductor differential pair that does not require the traditional tail current source as a way to control the direct current and common-mode current is presented. Compared with a p-channel long-tailed pair, the proposed non-tailed solution operates under a higher maximum input common-mode voltage that includes (VDD + VSS)/2 even under low supply voltages. Experimental measurements on a prototype fabricated in a 0.35-µm technology (with metal–oxide–semiconductor thresholds greater than 0.6 V) confirm this behavior for supply voltages as low as 1.2 V, whereas the long-tailed pair with the same technology offers the same capability only for supplies higher than 1.6 V. Copyright © 2015 John Wiley & Sons, Ltd.

In this paper we extend the figures of merit for class AB symmetrical OTAs to the fully differential case and compare topologies from the literature. This analysis shows that the power consumption of the CMFB can have a significant role in determining the efficiency of the OTA, but on the other hand a CMFB is needed both to set the desired output common mode voltage and to improve the CMRR. We propose the complementary triode CMFB, i.e. a triode CMFB applied both at the NMOS and PMOS current mirrors, as suitable for class AB symmetrical OTAs, and show some case studies in deep submicron CMOS technology to assess the effectiveness of the proposed solution. Copyright © 2015 John Wiley & Sons, Ltd.

The contact hypothesis suggests that the interaction between members of different groups decreases prejudice. Moderators and mediators shaping this link have been investigated. However, research about the factors that facilitate contact is not frequent. This article examines secure attachment as an antecedent of contact. Three studies provide information about various aspects of the relationship between secure attachment and contact: security is positively associated with (a) intergroup contact, which in turn is related to reduced prejudice (Study 1); (b) implicit approach tendencies toward the outgroup (Study 2); and, once again, (c) with contact through the indirect effect of openness to exploration (Study 3). In the discussion, we recommend priming both secure and insecure schemas to investigate their unique effects on intergroup contact.

In radiotherapy, only a few immobilization systems, such as open‐face mask and head mold with a bite plate, are available for claustrophobic patients with a certain degree of discomfort. The purpose of this study was to develop a remote‐controlled and self‐contained audiovisual (AV)‐aided interactive system with the iPad mini with Retina display for intrafractional motion management in brain/H&N (head and neck) radiotherapy for claustrophobic patients. The self‐contained, AV‐aided interactive system utilized two tablet computers: one for AV‐aided interactive guidance for the subject and the other for remote control by an operator. The tablet for audiovisual guidance traced the motion of a colored marker using the built‐in front‐facing camera, and the remote control tablet at the control room used infrastructure Wi‐Fi networks for real‐time communication with the other tablet. In the evaluation, a programmed QUASAR motion phantom was used to test the temporal and positional accuracy and resolution. Position data were also obtained from ten healthy volunteers with and without guidance to evaluate the reduction of intrafractional head motion in simulations of a claustrophobic brain or H&N case. In the phantom study, the temporal and positional resolution was 24 Hz and 0.2 mm. In the volunteer study, the average superior–inferior and right–left displacement was reduced from 1.9 mm to 0.3 mm and from 2.2 mm to 0.2 mm with AV‐aided interactive guidance, respectively. The superior–inferior and right–left positional drift was reduced from 0.5 mm/min to 0.1 mm/min and from 0.4 mm/min to 0.04 mm/min with audiovisual‐aided interactive guidance. This study demonstrated a reduction in intrafractional head motion using a remote‐controlled and self‐contained AV‐aided interactive system of iPad minis with Retina display, easily obtainable and cost‐effective tablet computers. This approach can potentially streamline clinical flow for claustrophobic patients without a head mask and also allows patients to practice self‐motion management before radiation treatment delivery. PACS number: 87.55.Gh

A design procedure for high-order continuous-time intermediate-frequency band-pass filters based on the cascade of low-Q biquadratic cells is presented. The approach is well suited for integrated-circuit fabrication, as it takes into account the maximum capacitance spread dictated by the available technology and maximum acceptable sensitivity to component variations. A trade-off between noise and maximum linear range is also met. A novel, wide-tuning-range transconductor topology is also described. Based on these results, a 10-pole band-pass filter for a code division multiple-access satellite receiver has been designed and tested. The filter provides tunable center frequency f0 from 10 to 70MHz and exhibits a 28-MHz bandwidth around f0=70MHz with more than 39-dB attenuation at f0/2 and 2f0. Third-order harmonic rejection is higher than 60dB for a 1-Vpp 70-MHz input, and equivalent output noise is lower than 1mVrms. The circuit is fabricated in a 0.25-µm complementary metal oxide semiconductor process, and the core consumes 12mA from a 2.5-V supply, offering the best current/pole ratio figure. The die area resulted to be 0.9×1.1mm2. Copyright © 2014 John Wiley & Sons, Ltd.

We conducted a field study to test whether the common ingroup identity model (Gaertner & Dovidio, 2000, reducing intergroup bias: The common ingroup identity model. Philadelphia, PA: Psychology Press) could be a useful tool to improve intergroup relations in the aftermath of a natural disaster. Participants were majority (Italian) and minority (immigrant) elementary school children (N = 517) living in the area struck by powerful earthquakes in May 2012. Results revealed that, among majority children, the perceived external threat represented by the earthquake was associated with greater perceptions of belonging to a common ingroup including both ingroup and outgroup. In turn, heightened one-group perceptions were associated with greater willingness to meet and help outgroup victims, both directly and indirectly via more positive outgroup attitudes. Among immigrant children, perceived disaster threat was not associated with any of the dependent variables; one-group perceptions were positively associated with outgroup attitudes, helping and contact intentions towards outgroup victims. Thus, one-group perceptions after a natural disaster may promote more positive and supporting relations between the majority and the minority group. We discuss the theoretical and practical implications of the findings.

Recent research shows that extended contact via story reading is a powerful strategy to improve out-group attitudes. We conducted three studies to test whether extended contact through reading the popular best-selling books of Harry Potter improves attitudes toward stigmatized groups (immigrants, homosexuals, refugees). Results from one experimental intervention with elementary school children and from two cross-sectional studies with high school and university students (in Italy and United Kingdom) supported our main hypothesis. Identification with the main character (i.e., Harry Potter) and disidentification from the negative character (i.e., Voldemort) moderated the effect. Perspective taking emerged as the process allowing attitude improvement. Theoretical and practical implications of the findings are discussed in the context of extended intergroup contact and social cognitive theory.