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Your search keyword '"Tomoaki Kawai"' showing total 3 results
Start Over Author "Tomoaki Kawai" Publisher wiley
3 results on '"Tomoaki Kawai"'

1. ChemInform Abstract: Enantioselective Cyanosilylation of Ketones with Lithium(I) Dicyanotrimethylsilicate(IV) Catalyzed by a Chiral Lithium(I) Phosphoryl Phenoxide

Author

Takahiro Horibe, Kazuaki Ishihara, Tomoaki Kawai, Manabu Hatano, and Katsuya Yamakawa

Subjects
inorganic chemicals, chemistry.chemical_classification, Base (chemistry), Chemistry, organic chemicals, Reagent, Enantioselective synthesis, chemistry.chemical_element, heterocyclic compounds, Lithium, General Medicine, Medicinal chemistry, Catalysis
Abstract

A highly enantioselective cyanosilylation of ketones was developed by using a chiral lithium(I) phosphoryl phenoxide aqua complex as an acid/base cooperative catalyst. The pentacoordinate silicate generated in situ from Me3SiCN/LiCN acts as an extremely reactive cyano reagent. Described is a 30 gram scale reaction and the synthesis of the key precursor to (+)-13-hydroxyisocyclocelabenzine.

Published
2016

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