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12 results on '"Tirosh, D."'

2. Adverse outcome following selective termination of presenting twin vs non‐presenting twin

Author

Miremberg, H., primary, Rosen, H., additional, Weisz, B., additional, Tirosh, D., additional, Hershkovitz, R., additional, Stern, S., additional, Porat, S., additional, Beloshevski, B., additional, Melcer, Y., additional, Goldberg, Y., additional, Boms Yonai, N., additional, Awawdeh, M., additional, Leibovitz, Z., additional, Shalev, J., additional, and Gindes, L., additional

Published
2023
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12. S100B in maternal circulation of pregnancies complicated by FGR and brain sparing.

Author

Swissa SS, Baron J, Tirosh D, Yaniv-Salem S, Shelef I, Hershkovitz R, and Beharier O

Subjects
Adult, Brain physiopathology, Female, Fetal Growth Retardation physiopathology, Humans, Placental Circulation genetics, Placental Circulation physiology, Pregnancy, Prospective Studies, S100 Calcium Binding Protein beta Subunit blood, Ultrasonography, Prenatal methods, Ultrasonography, Prenatal statistics & numerical data, Brain abnormalities, Fetal Growth Retardation diagnosis, Organ Sparing Treatments methods, S100 Calcium Binding Protein beta Subunit analysis
Abstract

Objective: To determine whether the presence of brain sparing in fetal growth restricted (FGR) fetuses involves elevation of the cerebral injury biomarker S100B in maternal circulation., Methods: We included 63 women with suspected small for gestational age (SGA) fetuses between 24 and 35 +6/7 weeks of gestation. Maternal plasma angiogenic factors measurements and sonographic evaluation were performed at recruitment. Next, we subdivided our SGA cohort into three groups: SGA fetuses, FGR fetuses without brain-sparing, and FGR fetuses with brain-sparing (FGR-BS). Serum S100B concentration was calculated as S100B µg/L, S100B MoM, and the ratio S100B/ estimated fetal weight (EFW). We also report one case of S100B concentration surge in maternal serum following the diagnosis of fetal intraventricular hemorrhage (IVH)., Results: The FGR-BS group had higher maternal S100B µg/L (p < 0.01, p < 0.05, respectively), S100B MoM (p < 0.001, p < 0.001, respectively), and S100B/EFW (p < 0.001, p < 0.01, respectively), compared to the SGA and FGR groups. In the case report, maternal serum S100B concentrations were 0.0346 µg/L before, and 0.0874 µg/L after IVH occurrence., Conclusions: S100B concentration in maternal serum increased in pregnancies complicated by FGR and brain sparing. These results may substantiate in-utero cerebral injury and may explain the adverse neurocognitive outcomes reported for this group., (© 2021 John Wiley & Sons Ltd.)

Published
2022
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