19 results on '"Tetsuo Maeda"'
Search Results
2. White esophagus accompanying multiple circumferential duodenal erosions extending to upper jejunum
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Akinori Kanzaki, Tetsuo Maeda, Akihito Otsuka, Kikuo Ichihara, Hidenori Koyama, Satoru Katayama, and Tadashi Nakamura
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black esophagus ,duodenum ,upper jejunum ,white esophagus ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Although white esophagus is an extremely rare disease, careful diagnosis and intensive treatment are required because of a relationship with black esophagus. Further case accumulation including duodenal and jejunum lesion is needed.
- Published
- 2021
- Full Text
- View/download PDF
3. Gastric Endocrine Cell Carcinoma Coexistent with Adenocarcinoma
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Nobuhiro Takeuchi, Nomura Yusuke, Tetsuo Maeda, and Kazuyoshi Naba
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Medicine - Abstract
A 69-year-old female presented to our institution with epigastralgia and abdominal distension. Upper gastrointestinal series revealed a 5 cm ulcerative lesion with irregular margins and elevated distinct borders from the angle to the pyloric ring. Gastroendoscopy revealed a Borrmann type 2 tumor. Several biopsied specimens revealed proliferation of small and heterogeneous cancer cells with rich chromatin and fibrous septum with rich vessels at connective tissues, which was confirmed as gastric endocrine cell carcinoma (ECC) on immunostaining with chromogranin and synaptophysin. Furthermore, other specimens revealed atypical cells forming glandular structures, which were confirmed as well-differentiated tubular adenocarcinomas. Distal gastrectomy with D2 lymph node dissection and Billroth I reconstruction was performed. Pathological examination of the gross specimen revealed that adenocarcinoma comprised
- Published
- 2013
- Full Text
- View/download PDF
4. A rare case of folliculotropic mycosis fungoides with eosinophilic pneumonia
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Yuma Hanaoka, Eiji Kiyohara, Mamori Tani, Shinsuke Kusakabe, Tetsuo Maeda, Atsushi Tanemura, and Manabu Fujimoto
- Subjects
Immunology and Allergy ,Dermatology - Published
- 2022
5. Case of hepatosplenic T‐cell lymphoma in a patient with dermatomyositis treated with prednisolone and azathioprine
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Natsuko Shimada, Yorihisa Kotobuki, Ichiro Katayama, Eiji Kiyohara, Satoshi Nojima, Jun Akome, Yukinobu Nakagawa, Tetsuo Maeda, Toshifumi Yamaoka, Manabu Fujimoto, and Mari Wataya-Kaneda
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medicine.medical_specialty ,business.industry ,Hepatosplenic T-cell lymphoma ,Prednisolone ,Azathioprine ,Dermatology ,General Medicine ,Dermatomyositis ,Lymphoma, T-Cell ,medicine.disease ,Gastroenterology ,Internal medicine ,Humans ,Medicine ,business ,medicine.drug - Published
- 2021
6. Primary cutaneous anaplastic large cell lymphoma with rapid liver infiltration after spontaneous resolution of the primary lesion
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Mari Wataya-Kaneda, Ichiro Katayama, Eiji Kiyohara, Manabu Fujimoto, Tetsuo Maeda, Yoichiro Morikawa, Reika Aoyama, Misa Hayashi, Atsushi Tanemura, and Miki Kume
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Pathology ,medicine.medical_specialty ,business.industry ,medicine ,Primary cutaneous anaplastic large cell lymphoma ,Dermatology ,General Medicine ,Primary lesion ,medicine.disease ,business ,Infiltration (medical) - Published
- 2020
7. White esophagus accompanying multiple circumferential duodenal erosions extending to upper jejunum
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Akihito Otsuka, Tetsuo Maeda, Kikuo Ichihara, Hidenori Koyama, Tadashi Nakamura, Akinori Kanzaki, and Satoru Katayama
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lcsh:Medicine ,duodenum ,Jejunum ,Lesion ,Clinical Images ,Duodenal erosions ,otorhinolaryngologic diseases ,Medicine ,Esophagus ,lcsh:R5-920 ,White (horse) ,upper jejunum ,business.industry ,Intensive treatment ,lcsh:R ,General Medicine ,Anatomy ,digestive system diseases ,black esophagus ,medicine.anatomical_structure ,white esophagus ,Clinical Image ,Duodenum ,medicine.symptom ,business ,lcsh:Medicine (General) ,Rare disease - Abstract
Although white esophagus is an extremely rare disease, careful diagnosis and intensive treatment are required because of a relationship with black esophagus. Further case accumulation including duodenal and jejunum lesion is needed.
- Published
- 2021
8. Evaluation of interobserver variability and diagnostic performance of developed MRI-based radiological scoring system for invasive placenta previa
- Author
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Satoru Takahashi, Kenji Tanimura, Yoshiko Ueno, Kazuro Sugimura, Yuko Suenaga, Tetsuo Maeda, Hideto Yamada, Kazuhiro Kitajima, and Utaru Tanaka
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medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Intraclass correlation ,Placenta accreta ,Prenatal diagnosis ,Magnetic resonance imaging ,medicine.disease ,030218 nuclear medicine & medical imaging ,Placenta previa ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Vascularity ,Placenta ,Medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,medicine.symptom ,business - Abstract
PURPOSE To evaluate the interobserver variability and diagnostic performance of a developed magnetic resonance imaging (MRI)-based scoring system for invasive placenta previa. MATERIALS AND METHODS Prenatal MR images of 70 women were retrospectively evaluated, 18 of whom were diagnosed with invasive placenta. The six MR features (dark band on T2 -weighted images, intraplacental abnormal vascularity, placental bulge, heterogeneous placenta, myometrial thinning, and placental protrusion sign) were scored on 5-point Likert scale separately, and the cumulative radiological score (CRS) was defined as the sum of each score. Two more experienced radiologists (readers A and B) and two less experienced residents (readers C and D) calculated the CRS. Interobserver variability was assessed by measuring the intraclass correlation coefficient. Diagnostic performance was evaluated by means of receiver operating characteristic (ROC) analysis. RESULTS Interobserver variability for CRS was excellent for the more experienced radiologists (0.85), and good for all readers (0.72) and the less experienced residents (0.66). The area under the ROC curve (Az) and accuracy (Acc) for CRS were significantly higher or equivalent to those of other MR features for all readers (Az and Acc for reader A; CRS, 0.92, 91.4%; intraplacental T2 dark band, 0.83, P = 0.009, 81.4%, P = 0.03; intraplacental abnormal vascularity, 0.9, P = 0.3, 90.0%, P = 1.00; placental bulge, 0.81, P = 0.0008, 80.0%, P = 0.02; heterogeneous placenta, 0.85, P = 0.11, 74.3%, P = 0.002; myometrial thinning, 0.84, P = 0.06, 60.0%, P < 0.0001; placental protrusion sign, 0.81, P = 0.01, 81.4%, P = 0.26). CONCLUSION This developed MRI-based scoring system demonstrated excellent or good interobserver variability, and good diagnostic performance for invasive placenta previa. J. Magn. Reson. Imaging 2016;44:573-583.
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- 2016
9. THE INFLUENCE OF TUMOR IMMUNE MICROENVIRONMENT AND TUMOR IMMUNITY ON THE PATHOGENESIS, TREATMENT AND PROGNOSIS OF POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS (PTLD)
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Kentaro Fukushima, Kouichi Ohshima, Hiroaki Miyoshi, Masao Seto, Kenji Oritani, Jun Toda, Yuzuru Kanakura, Tetsuo Maeda, Takafumi Yokota, Masao Mizuki, Hirohiko Shibayama, Hideaki Saito, Shinsuke Kusakabe, Michiko Ichii, and Jiro Fujita
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Cancer Research ,business.industry ,Immune microenvironment ,Lymphoproliferative disorders ,Hematology ,General Medicine ,Tumor immunity ,medicine.disease ,Post transplant ,Pathogenesis ,Oncology ,Immunology ,medicine ,business - Published
- 2019
10. Thrombocytopenia associated with Mycoplasma pneumonia during pregnancy: Case presentation and approach for differential diagnosis
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Aiko Nishikawa, Tetsuo Maeda, Kazuya Mimura, Takuji Tomimatsu, Tadashi Kimura, and Takeshi Kanagawa
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Pediatrics ,medicine.medical_specialty ,Cytopenia ,Pregnancy ,Mycoplasma pneumoniae ,Hemophagocytic lymphohistiocytosis ,business.industry ,Obstetrics and Gynecology ,medicine.disease ,medicine.disease_cause ,Azithromycin ,respiratory tract diseases ,Immune system ,hemic and lymphatic diseases ,Immunology ,Mycoplasma pneumonia ,medicine ,Differential diagnosis ,business ,medicine.drug - Abstract
Thrombocytopenia during pregnancy has many different causes, but Mycoplasma pneumoniae is not usually considered one of the several pathogens that induce thrombocytopenia. Herein, we present a case of severe thrombocytopenia that was associated with M. pneumoniae during pregnancy. The patient experienced fever, cough, and cytopenia with M. pneumoniae-specific IgM antibody increasing from 40-fold to 160-fold during the 2 weeks of illness. A diagnosis was made after excluding other diseases that cause thrombocytopenia. The patient was successfully treated with azithromycin hydrate, and she delivered a healthy newborn without any complications. Pregnant women who are infected with M. pneumoniae during pregnancy may develop severe and fatal thrombocytopenia. Prompt diagnosis and initiation of treatment lead to early recovery.
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- 2015
11. Recent topics related to nephrogenic systemic fibrosis associated with gadolinium-based contrast agents
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Yoshiko Ueno, Kazuro Sugimura, Sanae Watanabe, Kazuhiro Kitajima, and Tetsuo Maeda
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Pathology ,medicine.medical_specialty ,Fibrosing disease ,medicine.diagnostic_test ,business.industry ,Urology ,Gadolinium ,Acute kidney injury ,chemistry.chemical_element ,Renal function ,Magnetic resonance imaging ,medicine.disease ,Gastroenterology ,chemistry ,Internal medicine ,Nephrogenic systemic fibrosis ,medicine ,In patient ,business - Abstract
Nephrogenic systemic fibrosis is a progressive, potentially fatal, multiorgan-system fibrosing disease related to exposure of patients with renal failure to gadolinium-based contrast agents used in magnetic resonance imaging. Between 1997 and 2007, more than 500 cases of nephrogenic systemic fibrosis in patients with severe renal insufficiency (glomerular filtration rate less than 30 mL/min/1.73 m(2)) were reported, and no known cases of nephrogenic systemic fibrosis have occurred in patients with a glomerular filtration rate of more than 30 mL/min/1.73 m(2) without acute kidney injury. Additional major risk factors are use of high-dose and specific gadolinium-based contrast agents, a pro-inflammatory state. Although the mechanism of nephrogenic systemic fibrosis is unclear and there is no consistently-effective therapy, nephrogenic systemic fibrosis is an entity that can be eliminated by observing recent recommended guidelines for gadolinium-based contrast agents and nephrogenic systemic fibrosis. This article reviews current knowledge about nephrogenic systemic fibrosis and focuses mainly on how to prevent it.
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- 2012
12. Recent issues in contrast-induced nephropathy
- Author
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Kazuhiro Kitajima, Tetsuo Maeda, Sanae Watanabe, and Kazuro Sugimura
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Urology ,Contrast-induced nephropathy ,Computed tomography ,medicine.disease ,Nephropathy ,Nephrotoxicity ,Contrast medium ,High morbidity ,Iodinated contrast ,medicine ,Radiology ,business ,Complication - Abstract
Contrast-induced nephropathy (CIN) is a serious complication resulting from the use of iodinated contrast medium (CM) with potentially high morbidity and mortality. Patients with pre-existing renal insufficiency appear to be at higher risk of CIN. To prevent CIN among patients undergoing contrast-enhanced computed tomography, every effort is required, including routine identification of at-risk patients, the use of appropriate hydration regimens, withdrawal of nephrotoxic drugs, selection of low-osmolality CM or iso-osmolar CM, and using the minimum volume of CM possible.
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- 2011
13. Post-transplant lymphoproliferative disorder following renal transplantation: A single-center experience over 40 years
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Yoichi Kakuta, Akihiko Okuyama, Tetsuo Maeda, Masayoshi Okumi, Yukito Kokado, Norio Nonomura, Ryoichi Imamura, Shiro Takahara, Yoshitaka Isaka, Naotsugu Ichimaru, and Toyofumi Abe
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medicine.medical_specialty ,Combination therapy ,business.industry ,Urology ,Incidence (epidemiology) ,medicine.disease ,Single Center ,Tacrolimus ,Post-transplant lymphoproliferative disorder ,Surgery ,Transplantation ,surgical procedures, operative ,hemic and lymphatic diseases ,medicine ,Rituximab ,business ,Progressive disease ,medicine.drug - Abstract
Objectives: To investigate post-transplant lymphoproliferative disorder (PTLD) following renal transplantation at our institution. Methods: Medical records of 631 patients who underwent renal transplantation at Osaka University Hospital between March 1965 and December 2008 were reviewed. Results: PTLD following renal transplantation was detected in 10 patients (five men, five women; mean age at transplantation, 38.5 years). Mean duration from renal transplantation to the onset of PTLD was 7.1 years (range, 5 months to 18 years, 9 months). Mean duration of observation was 3.9 years from the onset of PTLD. Immunosuppressant therapy comprised multidrug combination therapy, including cyclosporine in six patients and tacrolimus in four patients. In addition to a reduction in the immunosuppressant dose, which was performed in all patients, PTLD was treated with surgery in seven patients, radiotherapy in two patients, rituximab in five patients, and cytotoxic chemotherapy in four patients. A complete remission in eight patients and progressive disease in two were observed. At last follow up, seven patients were alive and five patients had functioning grafts. Conclusions: The incidence of PTLD following renal transplantation at our institution is 1.6% with onset occurring more than 5 years after transplantation in five patients. Consequently, with long-term renal graft survival now feasible, attention must be paid to detecting late-onset PTLD.
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- 2009
14. Melanin and facial skin fluorescence as markers of yellowish discoloration with aging
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Masatoshi Itoh, Hiroshi Ohshima, Midori Oyobikawa, Hiromi Kanto, Tetsuo Maeda, Akihiro Tada, and Hirotsugu Takiwaki
- Subjects
Adult ,Glycation End Products, Advanced ,medicine.medical_specialty ,Photoaging ,Color ,Pilot Projects ,Skin Pigmentation ,Dermatology ,Intrinsic fluorescence ,Models, Biological ,Fluorescence ,Skin Aging ,Melanin ,Hemoglobins ,Young Adult ,Internal medicine ,medicine ,Humans ,Melanins ,integumentary system ,Subject Age ,Chemistry ,Photoaged skin ,Middle Aged ,medicine.disease ,Surgery ,Facial skin ,Endocrinology ,Spectrophotometry ,Face ,Female ,Epidermis ,Biomarkers - Abstract
BACKGROUND Although one clinical sign of aging and/or photoaging is a yellowish discoloration of the facial skin, little is known about the cause of this change. In addition to the increase in the epidermal melanin content, it has been suggested that advanced glycation end products (AGEs), which are known to accumulate in photoaged skin, may affect this discoloration. AIM The objective of this pilot study was to non-invasively investigate the roles of melanin and AGEs in this yellowish discoloration of the facial skin. METHODS We examined the spectral reflectance at the cheek in 40 healthy Japanese women of various ages (mean age, 38.1 years) using a reflectance spectrophotometer and a spectrofluorimeter. The degree of yellowish tint was evaluated in terms of b(*). The amount of melanin in the skin was evaluated by calculating the melanin index (MI) A(640)-A(670) [A(lambda): log(10) (1/reflectance) at a wavelength of lambda]. The amount of AGEs was roughly evaluated using the AGEs index, which is thought to linearly correlate with the amount of intrinsic fluorescence markers irrespective of the concentration of melanin and is defined as follows: AGEs index=I(5)/SQR (I(1)xI(2)). In this equation, the intensities of reflectance are I(1) at an excitation wavelength of 335 nm, I(2) at an emission wavelength of 390 nm and I(5) at 390 nm under an excitation wavelength of 335 nm. RESULTS Both b(*) and the AGEs index were significantly correlated with subject age (r=0.34, P
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- 2009
15. Influence of Physician Specialty on Treatment Goals for Diabetic Patients : Results of a Survey given to the Members of the Ishikawa Medical Association
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Tetsuo Maeda, Akimichi Asano, Junji Koizumi, Masako Kitatani, Toshinari Takamura, Hideki Nomura, Tomoharu Matsukura, Kunio Kondou, and Osamu Oyama
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medicine.medical_specialty ,Physician specialty ,business.industry ,Family medicine ,medicine ,Questionnaire ,Treatment goals ,business ,Association (psychology) ,Diabetes treatment - Published
- 2008
16. Identification of amino-terminal region of adiponectin as a physiologically functional domain
- Author
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Yoshihiro Kamada, Isao Takahashi, Hidetoshi Ujiie, Tetsuo Maeda, Shinji Kihara, Tohru Funahashi, Yuzuru Kanakura, Shinji Tamura, Hisashi Kato, Yoshiaki Tomiyama, Michiko Ichii, Takafumi Yokota, Hiroaki Masaie, and Kenji Oritani
- Subjects
Stromal cell ,Molecular Sequence Data ,Adipokine ,Inflammation ,Biology ,Biochemistry ,Epitope ,Epitopes ,Mice ,medicine ,Animals ,Humans ,Amino Acid Sequence ,Receptor ,Molecular Biology ,Peptide sequence ,Adiponectin ,nutritional and metabolic diseases ,Cell Biology ,Peptide Fragments ,Protein Structure, Tertiary ,Mice, Inbred C57BL ,Epitope mapping ,medicine.symptom ,Epitope Mapping ,hormones, hormone substitutes, and hormone antagonists - Abstract
Adiponectin is an abundant adipose-specific protein, which acts as an anti-diabetic, anti-atherogenic, and anti-inflammatory adipokine. Although recent advances in the field of adiponectin have been made by the identification of adiponectin receptors and by the understanding about relationship between its multimerization and functions, detailed molecular background remains unclear. Our established anti-human adiponectin antibodies, ANOC 9103 and ANOC 9104, blocked some adiponectin functions such as the growth inhibition of B-lymphocytes on stromal cells and the inhibition of acetylated LDL uptake in macrophages, suggesting that they may recognize important functional regions of adiponectin. As a result of epitope mapping based on the ability to bind to the deleted adiponectin mutants, we identified that these antibodies recognize amino-terminal region of adiponectin before the beginning of the collagen-like domain. Notably, a peptide fragment (DQETTTQGPGVLLPLPKGACTGWMA) corresponding to amino acid residues 17-41 of human adiponectin could bind to restricted types of cells and block adiponectin-induced cyclooxygenase-2 gene expression and prostaglandin E2 production in MS-5 stromal cells. Moreover, the deletion of its amino-terminal region reduced the abilities to inhibit not only collagen-induced platelet aggregation but also diet-induced hepatic steatosis. These data indicate that amino-terminal region of adiponectin is a physiologically functional domain and that a novel receptor, which recognizes amino-terminal region of adiponectin, may exist on some types of cells. Further investigations will contribute to the understanding of molecular mechanisms about adiponectin functions as well as to the designing of novel strategies for the treatment of patients with insulin-resistance, vascular dysfunction, and chronic inflammation.
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- 2006
17. Hepatic nodules with early enhancement during computed tomography portography: Report of six cases
- Author
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Michiie Sakamoto, Yukio Muramatsu, Fumihiko Wakao, Yasunori Mizuguchi, Kenichi Takayasu, Tetsuo Maeda, Ryoko Iwata, and Noriyuki Moriyama
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Male ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Tomography Scanners, X-Ray Computed ,Lesion ,Carcinoma ,medicine ,Humans ,Atypical adenomatous hyperplasia ,Portography ,Aged ,Hyperplasia ,Hepatology ,medicine.diagnostic_test ,business.industry ,Liver Neoplasms ,Gastroenterology ,Focal nodular hyperplasia ,Angiography, Digital Subtraction ,Middle Aged ,medicine.disease ,Radiographic Image Enhancement ,Liver ,Hepatocellular carcinoma ,Angiography ,Radiology ,medicine.symptom ,business ,Precancerous Conditions - Abstract
Aim: To study the clinicopathologic characteristics of hepatic nodular lesions with high attenuation (increased portal blood flow) compared with surrounding hepatic parenchyma on computed tomography (CT) during arterial portography (CTAP). Methods : For six lesions found in six patients demonstrated as a high-attenuated mass by CTAP, CT during hepatic arteriography (CTHA; n = 3 patients), digital subtraction hepatic arteriography (n = 6) and conventional helical CT (n = 6) were evaluated retrospectively and compared with histopathologic findings (n = 4). Pathologic diagnosis was atypical adenomatous hyperplasia, nodule-in-nodule hepatocellular carcinoma (HCC) in one resected lesion each and overt HCC in two biopsied lesions. Two patients did not undergo any therapy and were followed up. Results : The average size of lesions was 2.2 cm (range 1.2–3.5 cm). The CTAP revealed high attenuation in all six lesions; entirely within the lesion (n = 4 lesions) or peripherally with a central low attenuation (n = 2). In contrast, CTHA showed low attenuated lesions; entirely within the mass (n = 2) or peripherally with a central high-attenuated spot (n = 1). Hepatic arteriogram revealed only two hypervascular lesions; entirely and partially in one each. In the arterial phase of helical CT, all but one lesion were iso- or hypo-attenuated. In two patients who were followed up to 39 and 55 months without therapy, neither tumor growth nor hemodynamic change of the lesion was recognized on CT. Conclusions: Even though the incidence of hepatic nodular lesions demonstrated as high attenuating on CTAP is low, all but one lesion in the current series showed iso- or hypo-attenuation on CTHA and/or helical CT, suggesting the hemodynamics are reciprocal between CTAP and CTHA. One exceptional lesion that showed high attenuation on both CTAP and conventional CT was pathologically advanced HCC. Based on the follow-up study of two untreated patients, this kind of lesion with high attenuation on CTAP seems to grow slowly. © 2002 Blackwell Publishing Asia Pty Ltd
- Published
- 2002
18. Value of gonadotropin-releasing hormone agonist in diagnosing peritoneal pseudocysts
- Author
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Tetsuo Maeda, Kyo Tsuda, Omi Higashiguchi, Akira Miyake, Hironobu Nakamura, Takamichi Murakami, and Hirohisa Kurachi
- Subjects
Adult ,Ovulation ,Agonist ,medicine.medical_specialty ,Gonadotropin RH ,medicine.drug_class ,Ovariectomy ,medicine.medical_treatment ,Endometriosis ,Peptide hormone ,Peritoneal Diseases ,Gonadotropin-Releasing Hormone ,Peritoneal cavity ,Pregnancy ,Internal medicine ,Gonadotropin-releasing hormone agonist ,Transvaginal sonography ,medicine ,Humans ,Menstrual Cycle ,Ultrasonography ,Chemotherapy ,Cysts ,business.industry ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Endocrinology ,medicine.anatomical_structure ,Female ,business - Published
- 1996
19. ULTRASTRUCTURE OF INCONTINENTIA PIGMENTI ACHROMIANS, WITH SPECIAL REFERENCE TO MELANOCYTES AND NERVE ENDINGS
- Author
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Ryoichi Igarashi, Tetsuo Maeda, Masaaki Morohashi, and Shozo Takahashi
- Subjects
Nerve Endings ,Pathology ,medicine.medical_specialty ,Biopsy ,Schwann cell ,Dermatology ,General Medicine ,Incontinentia pigmenti achromians ,Melanocyte ,Biology ,medicine.disease ,Microscopy, Electron ,medicine.anatomical_structure ,Vacuolization ,Child, Preschool ,medicine ,Ultrastructure ,Humans ,Melanocytes ,Female ,Basal lamina ,Epidermis ,Pigmentation Disorders ,Free nerve ending ,Skin - Abstract
Studies of a new Japanese case of incontinentia pigmenti achromians were made by electron microscopy. At the periphery of the depigmented lesions, the melanocytes had several subcellular abnormalities; i.e., vacuolization of the cytoplasm, aggregation of melanosomes, and autophagic vacuoles. Many non-specific basal dendritic cells could be identified as non-pigment producing melanocytes. The depigmentation in this disease seemed to have been caused by both melanocyte degeneration and inactivation. Numerous nerve endings were seen in close contact with the basal lamina of the epidermis or even within the epidermis. Direct contacts between melanocytes and free nerve endings were presumed when a direct continuity between the Schwann cell basal lamina of the nerve ending and the basal lamina of melanocytes was observed. It was further observed in this study that nerve endings could be found associated with either normal or degenerated melanocytes. Apparently normal melanocytes in the lesion may not be entirely normal in function.
- Published
- 1981
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